List of publications using CHIR 99021 (Axon 1386) purchased from Axon Medchem

(Total 323 publication citations listed from 2009 until August 2017)

2017 (51 new publication citations in 2017)
Warrier, S., Van der Jeught, M., Duggal, G., Tilleman, L., Sutherland, E., Taelman, J., ... & Peelman, L. (2017). Direct comparison of distinct naive pluripotent states in human embryonic stem cells. Nature Communications, 8: 15055.

Hohwieler, M., Illing, A., Hermann, P. C., Mayer, T., Stockmann, M., Perkhofer, L., ... & Kuo, C. C. (2017). Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling. Gut, 66(3), 473-486.
(Chir99021 and SB431542 from Axon Medchem)

Yamaguchi, T., Sato, H., Kato-Itoh, M., Goto, T., Hara, H., Sanbo, M., ... & Ota, Y. (2017). Interspecies organogenesis generates autologous functional islets. Nature, 542(7640), 191-196.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Kawamata, M., Katsuda, T., Yamada, Y., & Ochiya, T. (2017). In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules. Biochemical and Biophysical Research Communications, 482(4), 750-757.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Nigro, A. L., Prosper, F., & Aranguren, X. L. (2017). Generation of a Sprague-Dawley-GFP rat iPS cell line. Stem Cell Research. 2017, 21, 47-50.
(2i: CHIR99021 and PD0325901 from Axon Medchem).

Stryjewska, A., Dries, R., Pieters, T., Verstappen, G., Conidi, A., Coddens, K., ... & van Grunsven, L. A. (2017). Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells. Stem Cells, 35(3), 611-625.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Coppiello, G., Abizanda, G., Aguado, N., Iglesias, E., Iglesias-Garcia, O., Nigro, A. L., ... & Aranguren, X. L. (2017). Generation of a Sprague-Dawley-GFP rat iPS cell line. Stem Cell Research. 21, 40-43.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Coppiello, G., Abizanda, G., Aguado, N., Iglesias, E., Iglesias-Garcia, O., Nigro, A. L., ... & Aranguren, X. L. (2017). Isolation and characterization of Sprague-Dawley and Wistar Kyoto GFP rat embryonic stem cells. Stem Cell Research. 21, 47-50.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Yang, S., Ding, S., Xu, Q., Li, X., & Xiong, Q. (2017). Genetic Manipulation by Zinc-Finger Nucleases in Rat-Induced Pluripotent Stem Cells. Cellular Reprogramming (Formerly" Cloning and Stem Cells"). 19(3): 180-188.

Yoshimura, Y., Taguchi, A., & Nishinakamura, R. (2017). Generation of a Three-Dimensional Kidney Structure from Pluripotent Stem Cells. Organ Regeneration: 3D Stem Cell Culture & Manipulation, 179-193.

Kwok, C. K., Ueda, Y., Kadari, A., Günther, K., Heron, A., Schnitzler, A. C., ... & Edenhofer, F. (2017). Scalable stirred suspension culture for the generation of billions of human induced pluripotent stem cells using single‐use bioreactors. Journal of Tissue Engineering and Regenerative Medicine.

Hosokawa, Y., Toyoda, T., Fukui, K., Baden, M. Y., Funato, M., Kondo, Y., ... & Watanabe, A. (2017). Insulin‐producing cells derived from ‘induced pluripotent stem cells’ of patients with fulminant type 1 diabetes: vulnerability to cytokine insults and increased expression of apoptosis‐related genes. Journal of Diabetes Investigation. DOI: 10.1111/jdi.12727

Tosti, L., Ashmore, J., Tan, B. S. N., Carbone, B., Mistri, T. K., Wilson, V., ... & Kaji, K. (2017). Mapping transcription factor occupancy using minimal numbers of cells in vitro and in vivo. bioRxiv, 158931.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Ludwig, A. K., Zhang, P., Hastert, F. D., Meyer, S., Rausch, C., Herce, H. D., ... & Storm, C. (2017). Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise. Nucleic acids research, 45(5), 2438-2457.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Pieters, T., Haenebalcke, L., Bruneel, K., Vandamme, N., Hochepied, T., van Hengel, J., ... & Goossens, S. (2017). Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange. JoVE (Journal of Visualized Experiments), (122), e55575-e55575.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Zhang, P., Rausch, C., Hastert, F. D., Boneva, B., Filatova, A., Patil, S. J., ... & Cardoso, M. C. (2017). Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. Nucleic Acids Research.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Ziegenhain, C., Vieth, B., Parekh, S., Reinius, B., Guillaumet-Adkins, A., Smets, M., ... & Enard, W. (2017). Comparative analysis of single-cell RNA sequencing methods. Molecular cell, 65(4), 631-643.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Monzel, A. S., Smits, L. M., Hemmer, K., Hachi, S., Moreno, E. L., van Wuellen, T., ... & Berger, E. (2017). Derivation of human midbrain-specific organoids from neuroepithelial Stem Cells. Stem cell reports, 8(5), 1144-1154.

Katsuda, T., Kawamata, M., Hagiwara, K., Takahashi, R. U., Yamamoto, Y., Camargo, F. D., & Ochiya, T. (2017). Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity. Cell stem cell, 20(1), 41-55.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Cirelli, E., De Domenico, E., Botti, F., Massoud, R., Geremia, R., & Grimaldi, P. (2017). Effect Of Microgravity On Aromatase Expression In Sertoli Cells. Scientific Reports, 2017; 7: 3469.

Böscke, R., Vladar, E. K., Könnecke, M., Hüsing, B., Linke, R., Pries, R., ... & Wollenberg, B. (2017). Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps. American journal of respiratory cell and molecular biology, 56(5), 575-584.

KATAYAMA, M., HIRAYAMA, T., KIYONO, T., ONUMA, M., TANI, T., TAKEDA, S., ... & FUKUDA, T. (2017). Immortalized prairie vole-derived fibroblasts (VMF-K4DTs) can be transformed into pluripotent stem cells and provide a useful tool with which to determine optimal reprogramming conditions. Journal of Reproduction and Development, 2016-164.

A.S. Monzel, L.M. Smits, K. Hemmer, S. Hachi, E. L. Moreno,
T. van Wuellen, J. Jarazo, J. Walter, I. Bruggemann, I Boussaad, E. Berger,
R. M. Fleming, S. Bolognin, and J. C. Schwamborn. Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Stem Cell Reports. 2017, 8, 1144–1154.

Anton, T., & Bultmann, S. (2017). Site-specific recruitment of epigenetic factors with a modular CRISPR/Cas system. Nucleus, 1-8.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Hirsch, C., Striegl, B., Mathes, S., Adlhart, C., Edelmann, M., Bono, E., ... & Nyffeler, J. (2017). Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants. Archives of toxicology, 91(1), 407-425.

Katayama, M., Hirayama, T., Tani, T., Nishimori, K., Onuma, M., & Fukuda, T. (2017). Chick derived induced pluripotent stem cells by the poly‐cistronic transposon with enhanced transcriptional activity. Journal of Cellular Physiology.

van der Wal, E., Bergsma, A. J., van Gestel, T. J., LM, S., Zaehres, H., Araúzo-Bravo, M. J., ... & Pijnappel, W. P. (2017). GAA Deficiency in Pompe Disease Is Alleviated by Exon Inclusion in iPSC-Derived Skeletal Muscle Cells. Molecular Therapy-Nucleic Acids, 7, 101-115.

Murakami, N., Imamura, K., Izumi, Y., Egawa, N., Tsukita, K., Enami, T., ... & Inoue, H. (2017). Proteasome impairment in neural cells derived from HMSN-P patient iPSCs. Molecular brain, 10(1), 7.

Ehrlich, M., Mozafari, S., Glatza, M., Starost, L., Velychko, S., Hallmann, A. L., ... & Marteyn, A. (2017). Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Proceedings of the National Academy of Sciences, 114(11), E2243-E2252.

Gotoh, S. Generation of Alveolar Epithelial Spheroids via Isolated. Am. J. Physiol, 258, L134-L147.

Giacomelli, E., Bellin, M., Sala, L., Van Meer, B. J., Tertoolen, L. G., Orlova, V. V., & Mummery, C. L. (2017). Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development, dev-143438.

Gouti, M., Delile, J., Stamataki, D., Wymeersch, F. J., Huang, Y., Kleinjung, J., ... & Briscoe, J. (2017). A gene regulatory network balances neural and mesoderm specification during vertebrate trunk development. Developmental Cell, 41(3), 243-261.

Hoffmann, D., Schott, J. W., Geis, F. K., Lange, L., Müller, F. J., Lenz, D., ... & Schambach, A. (2017). Detailed comparison of retroviral vectors and promoter configurations for stable and high transgene expression in human induced pluripotent stem cells. Gene Therapy, 24(5), 298-307.

Nguyen, T. P., & Sieg, S. F. (2017). TGF-β inhibits IL-7-induced proliferation in memory but not naive human CD4+ T cells. Journal of Leukocyte Biology, jlb-3A1216.

Barakat, T. S., Halbritter, F., Zhang, M., Rendeiro, A. F., Bock, C., & Chambers, I. (2017). Functional dissection of the enhancer repertoire in human embryonic stem cells. bioRxiv, 146696.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Chal, J., Al Tanoury, Z., Oginuma, M., Moncuquet, P., Gobert, B., Miyanari, A., ... & Garnier, J. M. (2017). Recapitulating Early Development Of Mouse Musculoskeletal Precursors Of The Paraxial Mesoderm In Vitro. bioRxiv, 140574.
(* CHIR99021 and LDN193189 from Axon Medchem)

Thanisch, K., Song, C., Engelkamp, D., Koch, J., Wang, A., Hallberg, E., ... & Solovei, I. (2017). Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering. Differentiation, 94, 58-70.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., ... & Van Laake, L. W. (2017). Circadian networks in human embryonic stem cell‐derived cardiomyocytes. EMBO reports, e201743897.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Nakatsuji, N., Minami, I., Uesugi, M., & Aiba, K. (2017). U.S. Patent No. 9,587,220. Washington, DC: U.S. Patent and Trademark Office.

A. L. Nigro,* A. de Jaime-Soguero, R. Khoueiry, D. S. Cho, G. M. Ferlazzo, I. Perini, V. A. Escalona, X. L. Aranguren, S.M.C. de Sousa Lopes, K. P. Koh, P. Giulio Conaldi, W.-S. Hu, A. Zwijsen, F. Lluis, & C.M. Verfaillie.
PDGFRa+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Zhang, P., Ludwig, A. K., Hastert, F. D., Rausch, C., Lehmkuhl, A., Hellmann, I., ... & Cardoso, M. C. (2017). L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins. Nucleus, (May 2017 accepted), 1-15.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Amort, T., Rieder, D., Wille, A., Khokhlova-Cubberley, D., Riml, C., Trixl, L., ... & Lusser, A. (2017). Distinct 5-methylcytosine profiles in poly (A) RNA from mouse embryonic stem cells and brain. Genome biology, 18(1), 1.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Uliassi, E., Gandini, A., Perone, R. C., & Bolognesi, M. L. (2017). Neuroregeneration versus neurodegeneration: toward a paradigm shift in Alzheimer's disease drug discovery.

Kondo, Y., Toyoda, T., Ito, R., Funato, M., Hosokawa, Y., Matsui, S., ... & Watanabe, A. (2017). Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia, 1-13.

Ashida, Y., Nakajima‐Koyama, M., Hirota, A., Yamamoto, T., & Nishida, E. (2017). Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cells. Genes to Cells, 22(2), 189-202.

Glover, J. D., Wells, K. L., Matthäus, F., Painter, K. J., Ho, W., Riddell, J., ... & Mort, R. L. (2017). Hierarchical patterning modes orchestrate hair follicle morphogenesis. PLoS biology, 15(7), e2002117.

Marczenke, M., Piccini, I., Mengarelli, I., Fell, J., Röpke, A., Seebohm, G., ... & Greber, B. (2017). Cardiac Subtype-Specific Modeling of Kv1. 5 Ion Channel Deficiency Using Human Pluripotent Stem Cells. Frontiers in Physiology, 8.

Drouin‐Ouellet, J., Lau, S., Brattås, P. L., Ottosson, D. R., Pircs, K., Grassi, D. A., ... & Graff, C. (2017). REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and‐independent pathways. EMBO molecular medicine, 9(8), 1117-1131.
(*CHIR99021, SB431542 and LDN193189 from Axon Medchem)

Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., ... & Van Laake, L. W. (2017). Circadian networks in human embryonic stem cell‐derived cardiomyocytes. EMBO reports, e201743897.

Jason, J. Y., Paranjape, S. R., Walker, M. P., Choudhury, R., Wolter, J. M., Fragola, G., ... & Zylka, M. J. (2017). The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome. Journal of Biological Chemistry, jbc-M117.

Yi, J. J., Paranjape, S. R., Walker, M. P., Choudhury, R., Wolter, J. M., Fragola, G., ... & Zylka, M. J. (2017).
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.
JBC Papers in Press. Published on May 30, 2017 as Manuscript M117. 788448.

2016 (total 66 publication citations in 2016)
Sancho-Martinez, Ignacio, et al. "Establishment of human iPSC-based models for the study and targeting of glioma initiating cells." Nature communications 7 (2016).
2i CHIR99021 and PD0325901 were from Axon Medchem. 

Matsuno, Kunihiko, et al. "Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells." Differentiation (2016).
*CHIR99021 and LDN193189 were purchased from Axon Medchem.

Meek, Stephen, et al. "Reduced levels of dopamine and altered metabolism in brains ofHPRTknock-out rats: a new rodent model of Lesch-Nyhan Disease." Scientific reports 6 (2016): 25592.
2i:CHIR99021 and PD0325901 were purchased from Axon Medchem 

Vrij, Erik, et al. "Directed Assembly and Development of Material‐Free Tissues with Complex Architectures." Advanced Materials (2016). 

Becker, Matthias, et al. "Polycomb proteinBMI1 regulates osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells downstream of GSK3." Stem cells and development (2016). 

Sudheer, Smita, et al. "Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT‐Induced Presomitic Mesoderm."STEMCELLS (2016).
2i:CHIR99021 and PD0325901 were from Axon Medchem. 

Kugler, Josephine, et al. "Identification and characterization of teratogenic chemicals using embryonic stem cells isolated from a Wnt/β-Catenin-reporter transgenic mouse line." Toxicological Sciences (2016): kfw094.
*CHIR99021 and XAV939 from Axon Medchem

Huang, Jijun, et al. "Coupling switch of P2Y-IP3 receptors mediates differential Ca2+ signaling in human embryonic stem cells and derived cardiovascular progenitor cells." Purinergic signalling (2016): 1-14.

Rivron, Nicolas Clément, et al. "BLASTOID,CELLLINEBASED ARTIFICIAL BLASTOCYST."U.S.Patent No. 20,160,060,593.3 Mar. 2016. 

Den Hartogh, Sabine C. "Fluorescent gene reporters in human pluripotent stem cells: as model for studying human heart development and cardiomyocyte differentiation." (2016). 


Hara, Hiromasa, et al. "Rat Blastocysts from Nuclear Infection and Time-Lagged Enucleation and Their Commitment to Embryonic Stem Cells." Cellular Reprogramming (Formerly" Cloning and Stem Cells") 18.2 (2016): 108-115.

V Schwach et al. Generation and purification of human stem cell-derived cardiomyocytes.
Differentiation. 2016 Feb 22. pii: S0301-4681(16)30002-0.

H Neumann et al. Polysialic acid and use for treatment of neurodegenerative and neuroinflammatory diseases.
U.S. Patent 20,160,046,734.
(CHIR99021, SB431542 and Compound E(BZ) from Axon Medchem)

C Hirsch et al. Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants.
Arch Toxicol. 2016 Feb 29. [Epub ahead of print]
(2i:CHIR99021 and PD0325901 from Axon Medchem)

M Naujock et al. 4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from ALSPatient-Derived Induced Pluripotent Stem Cells.
Stem Cells. 2016 Mar 6. [Epub ahead of print]

J. Wang et al. Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression. 
Nat Protoc. 2016 Feb;11(2):327-46.
(2i:CHIR99021 and PD0325901 from Axon Medchem)

B. Linnartz‐Gerlachet al. Sialylation of neurites inhibits complement‐mediated macrophage removal in a human macrophage‐neuron Co‐Culture System.
Glia. 2016 Jan;64(1):35-47.
(CHIR99021 and SB431542 from Axon Medchem) 

U.S. Patent 20,160,002,600, issued January 7, 2016.

E.J. Vrij et al.. 3D High Throughput Screening and profiling of Embryoid Bodies in thermoformed microwell plates.
Lab Chip. 2016 Jan 18.

C. Ziegenhain et al. Comparative analysis of single-cell RNA-sequencing methods.
bioRxiv (2016): 035758.
(2i:CHIR99021 and PD0325901 from Axon Medchem)

B.C.Heng et al. An overview of protocols for the neural induction of dental and oral stem cells in vitro.
Tissue Eng Part B Rev. 2016 Jan 12.
(2i:CHIR99021 and PD0325901 from Axon Medchem)

2015  (total 53 publication citations)
J Chal et al. Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.
Nature Biotechnology 33, 962–969 (2015)

I.J. Huijbers et al.Using the GEMM-ESC strategy to study gene function in mouse models.
Nat Protoc. 2015 Nov;10(11):1755-85.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

M.J. Birket et al. Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells.
Nat Biotechnol. 2015 Sep;33(9):970-9.

H. Kawano et al. Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway.
Oncol Rep. 2015 Nov;34(5):2251-8.
(2i from Axon Medchem: CHIR99021 and PD0325901)

A. Kirkeby et al. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
C. Parish et al (Ed.) Developing stem cell-based therapies for neural repair.  Frontiers Media 2015, ISBN 2889194027, 9782889194025
(Y27632 and CHIR99021 from Axon Medchem)

H. Iseki et al. Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
Stem Cells. 2015 Nov 2.
(2i: CHIR99021 and PD0325901 from Axon Medchm)

S. Haraguchi et al. Chick embryos can form teratomas from microinjected mouse embryonic stem cells.
Dev Growth Differ. 2015 Dec 22.

C.W. van den Berg et al. Differentiation of human pluripotent stem cells to cardiomyocytes under defined conditions.
Methods Mol Biol. 2016;1353:163-80.

M. Ehrlich et al. Distinct neurodegenerative changes in an induced pluripotent stem cell model of frontotemporal dementia linked to mutant tau protein.
Stem Cell Reports. 2015 Jul 14;5(1):83-96.

G. Duggal et al. Alternative routes to induce naïve pluripotency in human embryonic stem cells.
Stem Cells. 2015 Sep;33(9):2686-98.

A. Shahraz et al. Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages.
Sci Rep. 2015 Nov 19;5:16800.
(CHIR99021, SB431542 and Compound E (DBZ) from Axon Medchem)

T. Palm et al. Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.
Sci Rep. 2015 Nov 6;5:16321.

L. Braunschweig et al. Oxygen regulates proliferation of neural stem cells through Wnt/β-catenin signalling.
Mol Cell Neurosci. 2015 Jul;67:84-92.

M.V. Krivega et al. Cyclin E1 plays a key role in balancing between totipotency and differentiation in human embryonic cells.
Mol Hum Reprod. 2015 Dec;21(12):942-56

B. Watmuff et al. Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling.
Front Cell Neurosci. 2015 Mar 31;9:104.

S. Meyer et al. Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells.
J Vis Exp. 2015 Jul 29;(101):e52831.

Y. Tabata et al. Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells.
J Biomol Screen. 2015 Oct;20(9):1074-83.

Z.E. Madeja et al. WNT/β-Catenin Signaling Affects Cell Lineage and Pluripotency-Specific Gene Expression in Bovine Blastocysts: Prospects for Bovine Embryonic Stem Cell Derivation.
Stem Cells Dev. 2015 Oct 15;24(20):2437-54.

T. Miura et al. Generation of primitive neural stem cells from human fibroblasts using a defined set of factors.
Biol Open. 2015 Oct 21;4(11):1595-607.

J. Rao et al. Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.
Cell Stem Cell. 2015 Dec 29. pii: S1934-5909(15)00517-2.

J. Chen et al. Evolutionary analysis across mammals reveals distinct classes of long noncoding RNAs.
bioRxiv, 2015 p.031385.

H.D. Devalla et al. Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology.
EMBO Mol Med. 2015 Feb 19;7(4):394-410.

B. Mühl et al. SPREDs (Sprouty Related Proteins with EVH1 Domain) promote self‐renewal and inhibit mesodermal differentiation in murine embryonic stem cells.
Dev Dyn. 2015 Apr;244(4):591-606.

B. Roese-Koerner. 2015. MicroRNAs in neural stem cell proliferation and differentiation
Doctoral dissertation, Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Diss., 2015.
(CHIR99021 and LDN193189 from Axon Medchem)

M. Zhang et al. Universal Cardiac Induction of Human Pluripotent Stem Cells in Two and Three‐Dimensional Formats: Implications for In Vitro Maturation.
Stem Cells. 2015 May;33(5):1456-69.

M. Hosoya et al. Method of producing pancreatic hormone-producing cells.
U.S. Patent 9157069 (B2)

A. Kamiya et al. MEK-ERK Activity Regulates the Proliferative Activity of Fetal Hepatoblasts Through Accumulation of p16/19cdkn2a.
Stem Cells Dev. 2015 Nov 1;24(21):2525-35.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation.
Van der Jeught M, Taelman J, Duggal G, Ghimire S, Lierman S, Chuva de Sousa Lopes SM., Deforce D, Deroo T, De Sutter P, Heindryckx B. 
Cell. Reprogram. 2015, 17(3): 170-180. doi:10.1089/cell.2014.0085.

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.
D’Uva, G., Aharonov, A., Lauriola, M., Kain, D., Yahalom-Ronen, Y., Carvalho, S., ... & Tzahor, E. (2015).
Nature Cell Biology 2015, 17, 627–638. doi:10.1038/ncb3149

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Bartfeld, S., Bayram, T., van de Wetering, M., Huch, M., Begthel, H., Kujala, P., ... & Clevers, H. (2015).
Gastroenterology, 148(1), 126-136.

DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes.
Cohen, I. S., Bar, C., Paz-Elizur, T., Ainbinder, E., Leopold, K., de Wind, N., ... & Livneh, Z.
Nucleic acids research, 2015, 43(3), 1637-1645.
*2i: CHIR99021 and PD0325901 from Axon Medchem

piggyBac Transposon-Based Insertional Mutagenesis in Mouse Haploid Embryonic Stem Cells.
Pettitt, S. J., Tan, E. P., & Yusa, K. (2015).
Chromosomal Mutagenesis, Methods in Meolecular Biology. 2015, Vol. 1239, pp. 15-28. Springer New York.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro–Correlation between contraction force and electrophysiology.
Ribeiro, M. C., Tertoolen, L. G., Guadix, J. A., Bellin, M., Kosmidis, G., D'Aniello, C., ... & Passier, R. (2015).
Biomaterials. 2015 May;51:138-50. doi: 10.1016/j.biomaterials.2015.01.067. Epub 2015 Feb 18. 

Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells.
Toyoda, T., Mae, S. I., Tanaka, H., Kondo, Y., Funato, M., Hosokawa, Y., ... & Osafune, K. (2015).
Stem cell research, 2015, 14(2), 185-197.

Generation of Rat Induced Pluripotent Stem Cells Using a Plasmid Vector and Possible Application of a Keratan Sulfate Glycan Recognizing Antibody in Discriminating Teratoma Formation Phenotypes.
Makanga, J. O., Kobayashi, M., Ikeda, H., Christianto, A., Toyoda, H., Yamada, M., ... & Inazu, T. (2015).
Biological and Pharmaceutical Bulletin, 38(1), 127-133. 

A modular open platform for systematic functional studies under physiological conditions.
Mulholland, C. B., Smets, M., Schmidtmann, E., Leidescher, S., Markaki, Y., Hofweber, M., ... & Bultmann, S. (2015).
Nucleic Acids Res. 2015 May 24. pii: gkv550. [Epub ahead of print]
*2i: CHIR99021 and PD0325901 from Axon Medchem

Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.
Yang, J., Wang, W., Ooi, J., Campos, L. S., Lu, L., & Liu, P.
STEM CELLS, 2015, 33(5), 1390-1404.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Dual Reporter MESP1mCherry/w‐NKX2‐5eGFP/w hESCs Enable Studying Early Human Cardiac Differentiation.
Den Hartogh, S. C., Schreurs, C., Monshouwer‐Kloots, J. J., Davis, R. P., Elliott, D. A., Mummery, C. L., & Passier, R. (2015).
Stem Cells. 2015 Jan;33(1):56-67. doi: 10.1002/stem.1842. 

Establishment of Tsc2‑deficient rat embryonic stem cells.
Ito, Y., Kawano, H., Kanai, F., Nakamura, E., Tada, N., Takai, S., ... & Hino, O.
International journal of oncology, 2015, 46(5), 1944-1952.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Establishment and Use of Mouse Haploid ES Cells.
Leeb, M., Perry, A. C., & Wutz, A.
Current Protocols in Mouse Biology, 2015, 155-185.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Functional Compensation Between Myc and PI3K Signaling Supports Self‐Renewal of Embryonic Stem Cells.
Hishida, T., Nakachi, Y., Mizuno, Y., Katano, M., Okazaki, Y., Ema, M., ... & Okuda, A.
Stem Cells, 2015, 33(3), 713-725.
Read more:
*2i: CHIR99021 and PD0325901 from Axon Medchem

Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy.
Friedrichs, S., Malan, D., Voss, Y., & Sasse, P. (2015).
Journal of Clinical Medicine, 4(1), 102-123.
*CHIR99021 and PD184352 from Axon Medchem 

Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells.
Masaki, H., Kato-Itoh, M., Umino, A., Sato, H., Hamanaka, S., Kobayashi, T., ... & Nakauchi, H. (2015).
Development. 2015 May 28. pii: dev.124016. [Epub ahead of print] 

Embryonic stem cell differentiation requires full length Chd1.
Piatti, P., Lim, C. Y., Nat, R., Villunger, A., Geley, S., Shue, Y. T., ... & Lusser, A.
Sci Rep. 2015 Jan 26;5:8007. doi: 10.1038/srep08007.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.
Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, et al.
PLoS Genet 11(5): e1005239. doi:10.1371/journal.pgen.1005239
*3i: SB431542, CHIR99021 and PD0325901 from Axon Medchem 

Funktionelle Analyse der Histon-Demethylase UTX in hämatopoetisch differenzierenden murinen ES-Zellen.
Kampka, J. (2015).
Doctoral dissertation of Julius-Maximilians-Universität Würzburg.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Universal Cardiac Induction of Human Pluripotent Stem Cells in Two and Three‐Dimensional Formats: Implications for In Vitro Maturation.
Zhang, M., Schulte, J. S., Heinick, A., Piccini, I., Rao, J., Quaranta, R., ... & Greber, B. (2015).
Stem Cells. 2015 May;33(5):1456-69. doi: 10.1002/stem.1964. 

Method for manufacturing pancreatic-hormone-producing cells.
Hosoya, M., Kunisada, Y., Shoji, M., & Yamazoe, N. (2015).
U.S. Patent No. 8932853.
*CHIR98014, CHIR99021, TDZD-8, SB216763, BIO, TWS-119, and SB415286 were purchased from Axon Medchem

A Protocol for Lentiviral Transduction and Downstream Analysis of Intestinal Organoids.
de Jeude, JFVL., Vermeulen, JL, Montenegro-Miranda, PS, Van den Brink, GR, & Heijmans, J.
J. Vis. Exp. (JoVE) 2015, 98, e52531-e52531. doi:10.3791/5253 

Successful Reprogramming of Epiblast Stem Cells by Blocking Nuclear Localization of β-Catenin.
Murayama, H., Masaki, H., Sato, H., Hayama, T., Yamaguchi, T., & Nakauchi, H. (2015).
Stem cell reports 4.1 (2015): 103-113.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Gene activation-associated long noncoding RNAs function in mouse preimplantation development.
Hamazaki, N., Uesaka, M., Nakashima, K., Agata, K., & Imamura, T. 
Development. 2015 Mar 1;142(5):910-20. doi: 10.1242/dev.116996. Epub 2015 Jan 29.

Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells.
Kurek, D., Neagu, A., Tastemel, M., Tüysüz, N., Lehmann, J., van de Werken, H. J., ... & ten Berge, D.
Stem Cell Reports. 2015, 4, 114-118.

2014 (total 38 publication citations)
YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response.
L Azzolin, T Panciera, S Soligo, E Enzo, S Bicciato, S Dupont, S Bresolin, C Frasson, G Basso, V Guzzardo, A Fassina, M Cordenonsi, S Piccolo.
Cell, 2014, 158 (1), 157-170. doi:10.1016/j.cell.2014.06.013
*CHIR99021 from Axon Medchem has been used in this study.

Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions.
van den Berg, C. W., Elliott, D. A., Braam, S. R., Mummery, C. L., & Davis, R. P. (2014). 
Methods in Molecular Biology, 10, 7651_2014_178.

Molecular and Functional Analyses of Motor Neurons Generated from Human Cord-Blood-Derived Induced Pluripotent Stem Cells. 
Naujock, M., Stanslowsky, N., Reinhardt, P., Sterneckert, J., Haase, A., Martin, U., ... & Petri, S. (2014). 
Stem cells and development, 23(24), 3011-3020.

Epigenetic Characterization of the FMR1 Promoter in Induced Pluripotent Stem Cells from Human Fibroblasts Carrying an Unmethylated Full Mutation.
de Esch, C. E., Ghazvini, M., Loos, F., Schelling-Kazaryan, N., Widagdo, W., Munshi, S. T., ... & Willemsen.
Stem Cell Reports. 2014, 3, 548–555.
* PD0325901 (1μM, ERK1/2i, Axon 1408); CHIR99021 (3μM, GSK3i, Axon 1386); SB203580 (10 μM, p38i, Axon 1363) Y-27632 (5μM, Axon 1683) from Axon Medchem.

A screen for transcription factor targets of Glycogen Synthase Kinase-3 highlights an inverse correlation of NFκB and Androgen Receptor Signaling in Prostate Cancer.
Campa, V. M., Baltziskueta, E., Bengoa-Vergniory, N., Gorroño-Etxebarria, I., Wesołowski, R., Waxman, J., & Kypta, R. M.
Oncotarget. 2014 Sep; 5(18): 8173–8187.

Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain. 
Hargus, G., Ehrlich, M., Araúzo-Bravo, M. J., Hemmer, K., Hallmann, A. L., Reinhardt, P., ... & Zaehres, H. (2014). 
Cell reports, 8(6), 1697-1703.

Erk Signaling Suppresses Embryonic Stem Cell SelfRenewal to Specify Endoderm.
Hamilton, W. B., & Brickman, J. M. 
Cell report, 2014, 9(6), 2056–2070.
*2i: CHIR99021 and PD0325901 from Axon Medchem 

Isolated naive pluripotent stem cells and methods of generating same.
Hanna, Yaqub, Noa Novershtern, and Yoach Rais. (2014).
US Patent Application 14/259,997. US 20140315301 A1
*2i CHIR99021 and PD0325901 and 20 other compounds from Axon Medchem

The role of chromatin organization and structure in neuronal differentiation.
Weng, M. K. 2014
PhD Thesis

Targeted organ generation using Mixl1-inducible mouse pluripotent stem cells in blastocyst complementation. 
Kobayashi, T., Kato-Itoh, M., & Nakauchi, H. (2014). 
Stem cells and development, 24(2), 182-189.
*2i used in this study and CHIR99021 from Axon Medchem

Direct Neural Conversion from Human Fibroblasts Using Self-Regulating and Nonintegrating Viral Vectors. 
Lau, S., Ottosson, D. R., Jakobsson, J., & Parmar, M. 
Cell reports, 2014, 9(5), 1673-1680.
*CHIR99021 and LDN193189 from Axon Medchem

Gene Targeting Study Reveals Unexpected Expression of Brain expressed X-linked 2 in Endocrine and Tissue Stem/progenitor Cells in Mice.
K Ito, S Yamazaki, R Yamamoto, Y Tajima, A Yanagida, T Kobayashi, M Kato-Itoh, S Kakuta, Y Iwakura, H Nakauchi and A Kamiya*.
J Biol Chem. 2014 Oct 24;289(43):29892-911. doi: 10.1074/jbc.M114.580084. Epub 2014 Aug 20.
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) were procured from Axon Medchem. 

The Generation and Maintenance of Rat Induced Pluripotent Stem Cells.
T Yamaguchi, S Hamanaka, H Nakauchi.
Stem Cells and Tissue Repair. Methods in Molecular Biology. 2014, 1210, 143-150. Date: 06 Aug 2014
*2i used and CHIR99021 from Axon Medchem

Dual reporter MESP1mCherry/w-NKX2-5eGFP/w hESCs enable studying early human cardiac differentiation.
SC Den Hartogh, C Schreurs, JJ Monshouwer-Kloots, RP Davis1, DA Elliott, C Mummery and R Passier.
Stem Cells. 2015 Jan;33(1):56-67. doi: 10.1002/stem.1842.

JC Clevers, T Sato, M Huch Ortega, W Richard.
US Patent Application 20140243227.
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) from Axon Medchem 

Identifying Nuclear Protein–Protein Interactions Using GFP Affinity Purification and SILAC-Based Quantitative Mass Spectrometry.
HI Baymaz, CG Spruijt, M Vermeulen.
Methods in Molecular Biology 2014, 1188, 207-226.
2i inhibitors (Axon Medchem, CHIR99021 and PD0325901 

Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells.
S Gotoh, I Ito, T Nagasaki, Y Yamamoto, S Konishi, Y Korogi, H Matsumoto, S Muro, T Hirai, M Funato, SI Mae, T Toyoda, A Sato-Otsubo, S Ogawa, K Osafune, M Mishima.
Stem Cell Reports, 2014, in press. DOI: 10.1016/j.stemcr.2014.07.005

Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.
C Dambrot, SR Braam, LGJ Tertoolen, M Birket, DE Atsma and CL Mummery.
J. Cell. Mol. Med., 2014, online 1 Jul 2014. DOI: 10.1111/jcmm.12356

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer.
AR Palla, D Piazzolla, M Abad, H Li, O Dominguez, HB Schonthaler, EF Wagner and M Serrano.
Oncogene 2014, 33, 2513–2519.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) from Axon Medchem 

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.
D Piazzolla, AR Palla, C Pantoja, M Cañamero… & M Serrano*.
Nature Communications, 2014, 5 (4226), in press. doi:10.1038/ncomms5226
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) are procured from Axon Medchem.

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation.
U Müller, C Bauer, M Siegl, A Rottach, H Leonhardt*
Nucl. Acids Res. (2014) online Jun 19, 2014. doi: 10.1093/nar/gku552
2i: PD0325901 (Axon 1408) and CHIR99021 (Axon 1386) 

Development of FGF2-dependent pluripotent stem cells showing naive state characteristics from murine preimplantation inner cell mass.
M Ozawa, E Kawakami, R Sakamoto, T Shibasaki, A Gotoa, N Yoshida.
Stem Cell Res. 2014, 13 (1), 75–87.  DOI: 10.1016/j.scr.2014.04.012
Read more: 

Effect of Leukemia Inhibitory Factor and Forskolin on Establishment of Rat Embryonic Stem Cell Lines.
M Hirabayashi, C TAMURA, M SANBO, H HARA, S Hochi.
J. Reprod. Devel. 2014, 60 (1), 78-82.  doi:  10.1262/jrd.2013-109

Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.
PK Shah, MP Walker, CE Sims, MB Major, NL Allbritton*
Integr. Biol.,2014, 6, 673-684.  DOI: 10.1039/C4IB00050A

Stepwise Differentiation of Pluripotent Stem Cells into Osteoblasts Using Four Small Molecules under Serum-free and Feeder-free Conditions.
K Kanke, H Masaki, T Saito, Y Komiyama, H Hojo, H Nakauchi, AC Lichtler, T Takato, U Chung, S Ohba.
Stem Cell Reports. 2014 May 22;2(6):751-60. doi: 10.1016/j.stemcr.2014.04.016. eCollection 2014.

The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele.
Y Shetzer, S Kagan, G Koifman, R Sarig, I Kogan-Sakin, M Charni, T Kaufman, M Zapatka, A Molchadsky, N Rivlin, N Dinowitz, S Levin, G Landan, I Goldstein, N Goldfinger, D Pe'er, B Radlwimmer, P Lichter, V Rotter and R Aloni-Grinstein. -
Cell Death & Differentiation, 2014, (16 May 2014) | doi:10.1038/cdd.2014.57

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
T Pfaffeneder, F Spada, M Wagner, C Brandmayr, SK Laube, D Eisen, M Truss, J Steinbacher, B Hackner, O Kotljarova, D Schuermann, S Michalakis, Olesea Kosmatchev, S Schiesser, B Steigenberger, N Raddaoui, G Kashiwazaki, U Müller, CG Spruijt, M Vermeulen, H Leonhardt, P Schär, M Müller & T Carell.
Nat Chem Biol. 2014 Jul;10(7):574-81. doi: 10.1038/nchembio.1532. Epub 2014 May 18.

Citrullination regulates pluripotency and histone H1 binding to chromatin.
MA Christophorou, G Castelo-Branco, RP Halley-Stott, CS Oliveira, R Loos, A Radzisheuskaya, KA Mowen, P Bertone, JCR Silva, M Zernicka-Goetz, ML Nielsen, JB Gurdon & T Kouzarides.
Nature 507, 104–108 (06 March 2014) doi:10.1038/nature12942
*both PD0325901 and CHIR99021 from Axon Medchem

FIREWACh: High-throughput Functional Detection of Transcriptional Regulatory Modules in Mammalian Cells.
M Murtha, Z Tokcaer-Keskin, Z Tang, F Strino, X Chen, Y Wang, X Xi, C Basilico, S Brown, R Bonneau, Y Kluger, and L Dailey.
Nat Methods. 2014 May;11(5):559-65. doi: 10.1038/nmeth.2885. Epub 2014 Mar 23.
*2i, PD0325901, 1 μM and CHIR99021, 3 μM from Axon Medchem 

Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.
D Smeets, Y Markaki, VJ Schmid, F Kraus, Anna Tattermusch, A Cerase, M Sterr, S Fiedler, J Demmerle, J Popken, H Leonhardt, N Brockdorff, T Cremer, L Schermelleh, M Cremer.
Epigenetics & Chromatin 2014, 7:8
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) from Axon Medchem 

IL-13 Orchestrates Resolution of Chronic Intestinal Inflammation via Phosphorylation of Glycogen Synthase Kinase-3β. 
S Fichtner-Feigl, R Kesselring, M Martin, F Obermeier, P Ruemmele, A Kitani, SM Brunner, M Haimer, EK Geissler, W Strober & HJ Schlitt. 
J Immunol. 2014 Apr 15;192(8):3969-80. doi: 10.4049/jimmunol.1301072. Epub 2014 Mar 14.

Engineering of midbrain organoids containing long-lived dopaminergic neurons. 
Tieng, V., Stoppini, L., Villy, S., Fathi, M., Dubois-Dauphin, M., & Krause, K. H. 
Stem Cells Dev. 2014 Jul 1;23(13):1535-47. doi: 10.1089/scd.2013.0442. Epub 2014 Apr 3.

Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells.
IJ Huijbers, RB Ali, C Pritchard, M Cozijnsen, MCh Kwon, N Proost, JY Song, H de Vries, J Badhai, K Sutherland, P Krimpenfort, EM Michalak, J Jonkers, A Berns.
EMBO Mol Med. 2014 Feb;6(2):212-25. doi: 10.1002/emmm.201303297. Epub 2014 Jan 8.
*2i, PD0325901 and CHIR99021 from Axon Medchem

Rapid identification of targeted transgene integrations in ES cells by fluorescence detection.
S Kautschitsch, L Andersen, S Hammerschmid, & T Rülicke.
Transgenic Res. 2014 Jun;23(3):469-75. doi: 10.1007/s11248-014-9782-3. Epub 2014 Jan 31.
*2i, MEK inhibitor PD0325901, 1 μM and GSK3 inhibitor CHIR99021, 3 μM from Axon Medchem 

GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. 
Enochson, L., Stenberg, J., Brittberg, M., & Lindahl, A. 
Osteoarthritis Cartilage. 2014 Apr;22(4):566-77. doi: 10.1016/j.joca.2014.02.004. Epub 2014 Feb 19.

Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.
GJ Litherland, W Hui, MS Elias, DJ Wilkinson, S Watson, C Huesa, DA Young and AD Rowan.
Arthritis Rheumatol. 2014 Aug;66(8):2175-87. doi: 10.1002/art.38681.

T Ishikawa
US Patent 20140137274A1.
*CHIR99021, PD184352, SU5402, PD174074, PD0325901, BIO etc from Axon Medchem 

2013 (*29 publications in 2013)
Derivation of novel human ground state naive pluripotent stem cells.

O Gafni, L Weinberger, AA Mansour, YS Manor, E Chomsky, D Ben-Yosef, Y Kalma, S Viukov, I Maza, A Zviran, Y Rais,  Z Shipony, Z Mukamel, V Krupalnik, M Zerbib, S Geula, I Caspi, D Schneir, T Shwartz, S Gilad, D Amann-Zalcenstein, S Benjamin, I Amit, A Tanay, R Massarwa, N Novershtern & JH Hanna.
Nature 2013, Published online 30 October 2013.  doi:10.1038/nature12745
Read more:
*CHIR99021 (Axon 1386), PD0325901 (Axon 1408), SB202190 (Axon 1364), BIRB796 (Axon 1358), Y-27632 (Axon 1693) used in this study were procured from Axon Medchem.

** SB203580 (Axon 1363) was also procured in large amount by Weizman Inst from Axon Medchem, however, this drug was noted from another supplier in the paper. 

Targeting and tracing of specific DNA sequences with dTALEs in living cells. 
Thanisch, K., Schneider, K., Morbitzer, R., Solovei, I., Lahaye, T., Bultmann, S., & Leonhardt, H. 
Nucleic acids research, 2013, gkt1348. doi: 10.1093/nar/gkt1348
*2i: PD0325901 and CHIR99021 from Axon Medchem

Identification of Ccr4-Not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
M Kamon, M Katano, K Hiraki-Kamon, T Hishida, Y Nakachi, Y Mizuno, Y Okazaki, A Suzuki, M Hirasaki, A Ueda, M Nishimoto, H Kato, and A Okuda. 
Stem Cells Develop. 2013, ahead of print. doi:10.1089/scd.2013.0326.
Read more: 

Deterministic direct reprogramming of somatic cells to pluripotency. 
Y Rais, A Zviran, S Geula, O Gafni, E Chomsky, S Viukov, AA Mansour, I Caspi, V Krupalnik, M Zerbib, I Maza, N Mor, D Baran, L Weinberger, DA Jaitin, D Lara-Astiaso, R Blecher-Gonen, Z Shipony, Z Mukamel, T Hagai, S Gilad, D Amann-Zalcenstein, ATanay, I Amit, N Novershtern & JH Hanna. 
Nature, 2013, 502 (7469), 65-70.
Read more: 

The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.
A Kumar, T Torii, Y Ishino, D Muraoka, T Yoshimura, A Togayachi, H Narimatsu, K Ikenaka and S Hitoshi.
J. Biol. Chem. published online August 28, 2013
Read more: 

Induced Pluripotent Stem Cells from Friedreich Ataxia Patients Fail to Up-regulate Frataxin during in vitro Differentiation to Peripheral Sensory Neurons.
A Eigentler, S Boesch, R Schneider, G Dechant, R Nat.
Stem Cells Develop. 2013, 22(24), 3271-3282. doi:10.1089/scd.2013.0126.
Read more: 

Tuning of β‐catenin Activity is Required to Stabilise Self‐renewal of Rat Embryonic Stem Cells. 
S Meek, J Wei, L Sutherland, B Nilges, M Buehr, SR Tomlinson, AJ Thomson, T Burdon.
STEM CELLS. 2013, 31 (10), 2104-2115. DOI: 10.1002/stem.1466
Read more: 

Characteristics of Bovine Inner Cell Mass-Derived Cell Lines and Their Fate in Chimeric Conceptuses.
T Furusawa, K Ohkoshi, K Kimura, S Matsuyama, S Akagi, M Kaneda, M Ikeda, M Hosoe, K Kizaki, and T Tokunaga.
Biol. Reprod. 2013, 2, 28. | doi: 10.1095/ biolreprod.112.106641
Read more:
(* Both CHIR99021 and PD184352 are from Axon Medchem) 

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer
AR Palla, D Piazzolla, M Abad, H Li, O Dominguez, HB Schonthaler, EF Wagner and M Serrano.
Oncogene , (10 June 2013) | doi:10.1038/onc.2013.196
Read more: 

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.
P Wend, L Fang, Q Zhu, JH Schipper, C Loddenkemper, F Kosel, V Brinkmann, K Eckert, S Hindersin, JD Holland, S Lehr, M Kahn, U Ziebold and W Birchmeier.
EMBO J. 2013, 32 (14), 1977-1989.  | doi:10.1038/emboj.2013.127
Read more: 

Epigenetic regulation of lentiviral and retroviral vectors in murine embryonic stem (ES) cells and genetic modification of ES cells with lentiviral vectors for application in regenerative medicine. 
TT LIM, 2013 PhD Thesis. Universitäts-und Landesbibliothek Bonn. (supervisors: A Pfeifer and DO Fürst)
Read more: 

Glycogen synthase kinase-3 (GSK-3) regulates TGF-β1-induced differentiation of pulmonary fibroblasts.
HA Baarsma, LHJM Engelbertink, LJ van Hees, MH Menzen, H Meurs, W Timens, DS Postma, HAM Kerstjens, R Gosens.
Br. J. Pharmacol. 2013, 169(3), 590-603. DOI: 10.1111/bph.12098 

Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal
endoderm, whereas Wnt/b-catenin signaling promotes differentiation into visceral endoderm.
I Chuykin, H Schulz, K Guan and M Bader.
J. Cell Sci. 2013, 126(1), 128-138. doi: 10.1242/jcs.110239
Read more: 

Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules. 
N Liu, M Wang, W Deng, CS Schmidt, W Qin, H Leonhardt, F Spada. 
PLoS ONE 2013, 8(5): e62755. doi:10.1371/journal.pone.0062755
Read more: 

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response.
J Heijmans, JF van Lidth de Jeude, BK Koo, SL Rosekrans, MCB Wielenga, M van de Wetering, M Ferrante, AS Lee, JJM Onderwater, JC Paton, AW Paton, AM Mommaas, LL Kodach, JC Hardwick, DW Hommes, H Clevers, V Muncan, GR van den Brink.
Cell Reports 2013, 3(4), 1128–1139.
Read more: 

Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog.
V Karwacki-Neisius, J Göke, R Osorno, F Halbritter, JH Ng, AY Weiße, FCK Wong, A Gagliardi, NP Mullin, N Festuccia, D Colby, SR Tomlinson, HH Ng, I Chambers.
Cell Stem Cell 2013, 12(5), 531-545.
Read more: 

Essential role of sox2 for the establishment and maintenance of the germ cell line.
F Campolo, M Gori, R Favaro, S Nicolis, M Pellegrini, F Botti, P Rossi, EA Jannini, S Dolci.
Stem Cells, 2013, online publication. DOI: 10.1002/stem.1392
Read more: 

Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal. 
Y Sanchez-Ripoll, HK Bone, T Owen, AMV Guedes, E Abranches, B Kumpfmueller, RV Spriggs, D Henrique, MJ Welham.
PLoS ONE 2013, 8(4): e60148. doi:10.1371/journal.pone.0060148
Read more: 

Deep proteome coverage based on ribosome profiling aids MS-based protein and peptide discovery and provides evidence of alternative translation products and near-cognate translation initiation events.
G Menschaert, W Van Criekinge, T Notelaers, A Koch, J Crappe, K Gevaert and P Van Damme.
Mol. Cell. Proteomics. 2013, 12, 1780-1790.  doi: 10.1074/mcp.M113.027540 

Derivation of a Germline Competent Transgenic Fischer 344 Embryonic Stem Cell Line
H Men, EC Bryda.
PLOS One 2013, 8(2): e56518. doi:10.1371/journal.pone.0056518 

Efficient Generation of Rat Induced Pluripotent Stem Cells Using a Non-Viral Inducible Vector.
C Merkl, A Saalfrank, N Riesen, R Kühn, A Pertek, S Eser, MS Hardt, A Kind, D Saur, W Wurst, A. Iglesias, A Schnieke.
PLoS ONE 2013, 8(1): e55170. doi:10.1371/journal.pone.0055170 

Efficient p53 gene targeting by homologous recombination in rat-induced pluripotent stem cells.
G Li, Y Chunxu, L Guisheng.
Cell Proliferation 2013, 46(1), 1–9. 

Pharmacological Inhibition of Glycogen Synthase Kinase 3 Regulates T Cell Development In Vitro.
JH Schroeder, LS Bell, ML Janas, M Turner.
PLoS ONE 2013, 8(3): e58501. doi:10.1371/journal.pone.0058501 

Phosphoinositide-3-kinases p110α and p110β mediate S phase entry in astroglial cells in the marginal zone of rat neocortex.
R Müller, C Fischer, T Wilmes, B Heimrich, V Distel, N Klugbauer, DK Meyer.
Front. Cell Neurosci. 2013, 7, 24. doi:  10.3389/fncel.2013.00024 PMCID: PMC3596864 

Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling. 
P Reinhardt, M Glatza, K Hemmer, Y Tsytsyura, CS Thiel, S Höing, S Moritz, JA Parga, L Wagner, JM Bruder, G Wu, B Schmid, A Röpke, J Klingauf, JC Schwamborn, T Gasser, HR Schöler, J Sterneckert.
PLoS ONE 2013, 8(3): e59252. doi:10.1371/journal.pone.0059252 

A retrospective analysis of germline competence in rat embryonic stem cell lines.
M Hirabayashi, C Tamura, M Sanbo, M Kato-Itoh, T Kobayashi, H Nakauchi, & S Hochi. 
Transgenic Res. 2013, 22 (2), 411-416.
Read more: 

Derivation of porcine induced pluripotent stem cells and somatic cells gene targeting in pig.
Xinxin Cu, PhD thesis. TECHNISCHE UNIVERSITÄT MÜNCHEN, Lehrstuhl für Biotechnologie der Nutztiere.
*2i: PD0325901 and CHIR99021 from Axon Medchem

Liver organoid, uses thereof and culture method for obtaining them
MH Ortega, JC Clevers. US 20130189327 A1
Read more: 

M Hosoya, Y Kunisada, M Shoji, & N Yamazoe.
U.S. Patent No. 20,130,022,986. 24 Jan. 2013.
Read more: 

(* 61 publications from 2009-2012, incomplete list extracted from >100 citations) 
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

CA Lyssiotis, RK Foreman, J Staerk, M Garcia, D Mathur, S Markoulaki, J Hanna, LL Lairson, BD Charette, LC Bouchez, M Bollong, C Kunick, A Brinker, CY Cho, PG Schultz and R Jaenisch.
PNAS 2009, 106 (22), 8912-8917.  doi: 10.1073/pnas.0903860106[Citation: 205, till Apr 8, 2013] 

Selective GSK-3β inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells.
HJ Park, HJ Kim, GS Bae, SW Seo, DY Kim, WS Jung, MS Kim, MY Song, EK Kim, KB Kwon, SY Hwang, HJ Song, CS Park, RK Park, MS Chong, SJ Park. 
Hearing Res. 2009, 257 (1-2), 53-62. 

Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells.
MY Chang, D Kim, CH Kim, HC Kang, E Yang, et al. 
PLoS ONE 2010, 5(3): e9838.  doi:10.1371/journal.pone.0009838
(*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.
S Li, MS Brown, and JL Goldstein.
PNAS 2010, 107 (8), 3441-3446. Read more: 

Generation of genetically modified rats from embryonic stem cells.
Masaki Kawamata and Takahiro Ochiya
PNAS 2010, 107 (32), 14223-14228.  doi: 10.1073/pnas.1009582107
(*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Identification and regulation of glycogen synthase kinase-3 during bovine embryo development.
IM Aparicio, M Garcia-Herreros, T Fair and P Lonergan
Reproduction 2010, 140, 83-92.  doi: 10.1530/REP-10-0040
Read more: 

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4.
ML Janas, G Varano, K Gudmundsson, M Noda,T Nagasawa, M Turner. 
J. Exp. Medicine (JEM), 2010, 207 (1), 247. doi: 10.1084/jem.20091430  

Interactions of Wnt/β-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons.
M Tang, JC Villaescusa, SX Luo, C Guitarte, S Lei, Y Miyamoto, MM Taketo, E Arenas, and EJ Huang.
J. Neuroscience, 2010, 30 (27), 9280-9291.
Read more: 

Inhibition of GSK3β enhances both adhesive and signalling activities of β-catenin in mouse embryonic stem cells.
Galina S. Sineva*, Valery A. Pospelov.
Biol. Cell. 2010, 102 (10), 549-564. DOI: 10.1042/BC20100016 

The Skp2 Promoter Integrates Signaling through the NF-κB, p53, and Akt/GSK3β Pathways to Regulate Autophagy and Apoptosis.
B Barré and ND Perkins.
Mol. Cell 2010, 38 (4), 524–538.
Read more: 

Distinct Developmental Ground States of Epiblast Stem Cell Lines Determine Different Pluripotency Features.
C Bernemann, B Greber, K Ko, J Sterneckert, DW Han, MJ Araúzo-Bravo, HR Schöler*
Stem Cells 2011, 29 (10), 1496-1503. (*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Generating gene knockout rats by homologous recombination in embryonic stem cells.
C Tong, G Huang, C Ashton, P Li , QL Ying*.
Nature Protocols 2011, 6, 827–844. 

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing.
B Zimmer, PB Kuegler, B Baudis… -
Cell Death and Differentiation 2011, 18, 383-395. 

Volatile anesthetic post-treatment induces protection via inhibition of glycogen synthase kinase 3 [beta] in human neuron-like cells.
D Lin, G Li, Z. Zuo.
Neuroscience 2011, 179, 73-79. 

Rat Embryonic Stem Cell Derivation and Propagation.
Ping Li, Eric N. Schulze, Chang Tong and Qi-Long Ying.
ADVANCED PROTOCOLS FOR ANIMAL TRANSGENESIS. Springer Protocols Handbooks, 2011, 457-475, DOI: 10.1007/978-3-642-20792-1_19 (*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Use of WNT stimulators for treating demyelinating diseases.
European Patent Application EP2305274 

Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: essential role of bone morphogenetic protein 4.
PM Chiang and PC Wong.
Development 2011, 138, 2833-2843. 

A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.
K Horie, C Kokubu, J Yoshida, K Akagi, A Isotani, A Oshitani, K Yusa, R Ikeda, Y Huang, A Bradley & J Takeda.
Nature Methods 2011, 8, 1071-1077. doi:10.1038/nmeth.1739
(*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Generation of germline-competent rat induced pluripotent stem cells.
S Hamanaka, T Yamaguchi, T Kobayashi, M Kato-Itoh, S Yamazaki et al. 
PLoS ONE 2011, 6(7): e22008. 

Glycogen synthase kinase-3 regulates cigarette smoke extract-and IL-1β-induced cytokine secretion by airway smooth muscle.
HA Baarsma, H Meurs, AJ Halayko, MH Menzen, M Schmidt, HAM Kerstjens, and R Gosens.
Am. J. Physiol. (AJP) - Lung Physiol 2011, 300 (6), L910-L919.
Read more: 

Derivation, Characterization, and Stable Transfection of Induced Pluripotent Stem Cells from Fischer344 Rats.
M Liskovykh, I Chuykin, A Ranjan, D Safina, E Popova, E Tolkunova, V Mosienko, JM Minina, NS Zhdanova, JJ Mullins, M Bader, N Alenina*, A Tomilin*.
PLoS ONE 2011, 6(11): e27345. doi:10.1371/journal.pone.0027345. 

Rat Embryonic Stem Cells: Establishment and Their Use for Transgenesis.
M Hirabayashi and S Hochi. - 

Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras.
A Isotani, H Hatayama, K Kaseda, M Ikawa, M Okabe*.
Genes to Cells 2011, 16 (4), 397–405.
*2i: CHIR99021 and PD0325901, from Axon Medchem

Loss of Dnd1 facilitates the cultivation of genital ridge-derived rat embryonic germ cells.
E Northrup, R Eisenblätter, S Glage, C Rudolph, M Dorsch, B Schlegelberger, HJ Hedrich, NH Zschemisch.
Exp. Cell Res. 2011, 317 (13), 1885–1894. 

US Patent Application 20110283374. (*2i: CHIR99021 and PD0325901, from Axon Medchem) 

PKC‐dependent endocytosis of the Helicobacter pylori vacuolating cytotoxin in primary T lymphocytes. 
X Sewald, L Jiménez-Soto, R Haas.
Cell. Microbiol. 2011, 13 (3), 482–496. (* CHIR99021 and BX795, from Axon Medchem) 

Wnt/{beta}-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma.
TL Biechele, RM Kulikauskas, RA Toroni, OM Lucero, RD Swift, RG James, NC Robin, DW Dawson, RT Moon, AJ Chien. 
Science Signal. 2012, 5 (206), ra3. 

Induced pluripotent stem cells from hair follicles as a cellular model for neurodevelopmental disorders.
I Petit, N Salman Kesner, R Karry, O Robicsek, E Aberdam, FJ Müller, D Aberdam, D Ben-Shachar.
Stem Cell Res. 2012, 8 (1), 134–140. 

Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells.
Y Kunisada, N Tsubooka-Yamazoe, M Shoji, M Hosoya.
Stem Cell Res. 2012, 8 (2), 274–284. 

RTEL1 contributes to DNA replication, repair and telomere maintenance.
EJ Uringa, K Lisaingo, HA Pickett… and PM Lansdorp*
Mol. Biol. Cell. 2012, mbc.E12-03-0179. 

Effect of Small Molecule Supplements during In Vitro Culture of Mouse Zygotes and Parthenogenetic Embryos on Hypoblast Formation and Stem Cell Derivation.
K. Versieren, M. Van der Jeught, T. O’Leary, G. Duggal, J. Gerris, S. Chuva de Sousa Lopes, B. Heindryckx and P. De Sutter.
STEM CELL REVIEWS AND REPORTS 2012, DOI: 10.1007/s12015-012-9382-7
*2i: CHIR99021 and PD0325901, from Axon Medchem

Lmx1a Allows Context‐Specific Isolation of Progenitors of GABAergic or Dopaminergic Neurons During Neural Differentiation of Embryonic Stem Cells.
CM Nefzger, CT Su, SA Fabb, BJ Hartley, SJ. Beh, WR Zeng, JM Haynes, CW Pouton.
STEM CELLS 2012, 30 (7), 1349–1361. 

Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo.
野田哲平 - 甲第 2470 号, 2012 -
URL: / 

Ability of tetraploid rat blastocysts to support fetal development after complementation with embryonic stem cells.
M Hirabayashi, C Tamura, M Sanbo, T Goto, M Kato-Itoh, T Kobayashi, H Nakauchi, S Hochi.
Mol. Repro. & Develop. 2012, 79 (6), 402-412. 

Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo.
T Noda, S Oki, K Kitajima, T Harada, S Komuneb, C Meno.
Devel. Biol. 2012, 362 (1), 83-93. 

TRIM6 interacts with c-Myc and maintains pluripotency of mouse embryonal stem cells.
T Sato, F Okumura, T Ariga, S Hatakeyama*.
J. Cell Sci. 2012, 125, 1544-1555. 

A Chemical Genomics Screen to Discover Genes That Modulate Neural Stem Cell Differentiation.
KJ Kim, J Wang, X Xu, S Wu, W Zhang, Z Qin, F Wu, A Liu, Y Zhao, H Fang, M Zhu, J Zhao, Z Zhong.
J. Biomol. Screen. 2012, 17(2), 129-139.  doi: 10.1177/1087057111422379 
Read more: 

Modulation of Neuronal Pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.
D Schvartz, Y Couté, Y Brunner, CB Wollheim and JC Sanchez*
Mol. & Cell. Proteomics 2012, 11, 244-254.  mcp.M112.018051.
Read more: 

In vitro expansion and functional recovery of mature hepatocytes from mouse adult liver.
H Ito, A Kamiya*, K Ito, A Yanagida, K Okada, H Nakauchi*
Liver International 2012, 32 (4), 592-601. (*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Germline Transmission of a Novel Rat Embryonic Stem Cell Line Derived From Transgenic Rats.
H Men, BA Bauer, and EC Bryda. 
Stem Cells and Development 2012, 21(14), 2606-2612. doi:10.1089/scd.2012.0040.
Read more: 


Identification of Rat Rosa26 Locus Enables Generation of Knock-in Rat Lines Ubiquitously Expressing tdTomato.
T Kobayashi, M Kato-Itoh, T Yamaguchi, C Tamura, M Sanbo, M Hirabayashi, and H Nakauchi. 
Stem Cells and Development 2012, 21(16): 2981-2986. doi:10.1089/scd.2012.0065.
Read more:
*2i: CHIR99021 and PD0325901, from Axon Medchem

GSK-3β activity in the hippocampus is required for memory retrieval.
JG Hong, DH Kim, CH Lee, SJ Park, JM Kim, M Cai, DS Jang, JH Ryu.
Neurobiol. Learn. Memory 2012, 98 (2) 122-129.
Read more: 

Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.
N Schmidt, S Basu, S Sladecek, S Gatti, J van Haren, S Treves, J Pielage, N Galjart, and HR Brenner. 
J Cell Biol, 2012, July, ahead of print.  doi: 10.1083/jcb.201111130. 

Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. 
LTY Cho, SE Wamaitha, IJ Tsai, J Artus, RI Sherwood, RA Pedersen, AK Hadjantonakis, KK Niakan*
Development 2012, 139, 2866-2877. 

A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions.
I Minami, K Yamada, TG Otsuji, T Yamamoto, Y Shen, S Otsuka, S Kadota, N Morone, M Barve, Y Asai, T Tenkova-Heuser, JE Heuser, M Uesugi, K Aiba, N Nakatsuji.
Cell Reports 2012, 2(5), 1448–1460. [online]
Read more: 

N-myc Downstream Regulated Gene 1 (NDRG1) Promotes Metastasis of Human Scirrhous Gastric Cancer Cells through Epithelial Mesenchymal Transition.
H Ureshino, Y Murakami, K Watari, H Izumi, A Kawahara, M Kage, T Arao, K Nishio, K Yanagihara, H Kinoshita, M Kuwano, M Ono.
PLoS ONE 2012, 7(7): e41312. doi:10.1371/journal.pone.0041312
Read more: 

Insulin Increases Epiblast Cell Number of In Vitro Cultured Mouse Embryos via the PI3K/GSK3/p53 Pathway.
JM Campbell, MB Nottle, I Vassiliev, M Mitchell, and M Lane. 
Stem Cells and Development. 2012, 21(13): 2430-2441. doi:10.1089/scd.2011.0598. 
Read more: 

Small Molecule-Assisted, Line-Independent Maintenance of Human Pluripotent Stem Cells in Defined Conditions. 
S Frank, M Zhang, HR Schöler, B Greber.
PLoS ONE 2012, 7(7): e41958. doi:10.1371/journal.pone.0041958 

Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells.
K Kemper, PR Prasetyanti, W De Lau, H Rodermond, H Clevers, JP Medema.
Stem Cell. 2012, 30(11), 2378–2386. 

Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states
LTY Cho, SE Wamaitha, IJ Tsai, J Artus, RI Sherwood, RA Pedersen, AK Hadjantonakis, KK Niakan.
Development 2012, 139, 2866-2877. doi: 10.1242/dev.078519 

A retrospective analysis of germline competence in rat embryonic stem cell lines.
M Hirabayashi, C Tamura, M Sanbo, M Kato-Itoh, T Kobayashi, H Nakauchi, S Hochi.
Transgenic Res. 2012, 22(2), 411-416. 

Two distinct knockout approaches highlight a critical role for p53 in rat development.
M Kawamata & T Ochiya. - - 
Scientific Reports 2012, 2, 945. doi:10.1038/srep00945 

Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
A Kirkeby, J Nelander, M Parmar
Front Cell Neurosci. 2012, 6, 64. doi: 10.3389/fncel.2012.00064 PMCID: PMC3539732 

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions.
A Kirkeby, S Grealish, DA Wolf, J Nelander, J Wood, M Lundblad, O Lindvall, M Parmar.
Cell Reports 2012, 1 (6), 703–714.
Read more: 

T Ochiya, M Kawamata.
United States Patent Application 20120272349 

T Ochiya, M Kawamata - European Patent Application EP2508595, issuedOctober 10, 2012. 

T Ishikawa, K Hagiwara, and T Ochiya.
European Patent EP 2532741, issuedDecember 12, 2012. 

Telomere Elongation During Morula-to-Blastocyst Transition in Cloned Porcine Embryos.
TQ Dang-Nguyen, S Haraguchi, S Akagi, T Somfai, M Kaneda, S Watanabe, K Kikuchi, A Tajima, T Nagai. 
Cell. Reprogram. 2012, 14(6), 514-519. doi:10.1089/cell.2012.0045. 

The Combination of Inhibitors of FGF/MEK/Erk and GSK3β Signaling Increases the Number of OCT3/4- and NANOG-Positive Cells in the Human Inner Cell Mass, But Does Not Improve Stem Cell Derivation.
M vd Jeught, T O'Leary, S Ghimire, S Lierman, G Duggal, K Versieren, D Deforce, SC de Sousa Lopes, B Heindryckx, P De Sutter. 
Stem Cells and Development. 2013, 22(2), 296-306. doi:10.1089/scd.2012.0256. 

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.
AA Mansour, O Gafni, L Weinberger, A Zviran, M Ayyash, Y Rais, Vl Krupalnik, M Zerbib, D Amann-Zalcenstein, I Maza, S Geula, S Viukov, L Holtzman, A Pribluda, E Canaani, S Horn-Saban, I Amit, N Novershtern & JH Hanna.
Nature 2012, 488, 409–413. doi:10.1038/nature11272 

Implication of DNA Demethylation and Bivalent Histone Modification for Selective Gene Regulation in Mouse Primordial Germ Cells.
K Mochizuki, M Tachibana, M Saitou, Y Tokitake, Y Matsui.
PLoS ONE 2012, 7(9): e46036. doi:10.1371/journal.pone.0046036 

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice.
P Serup, C Gustavsen, T Klein, LA Potter, R Lin, N Mullapudi, E Wandzioch, A Hines, A Davis, C Bruun, N Engberg, DR Petersen, JML Peterslund, RJ MacDonald, A Grapin-Botton, MA Magnuson and KS Zaret.
Dis. Model. Mech. 2012, 5(6), 956-966. doi: 10.1242/dmm.009696
Read more:

Human and mouse induced pluripotent stem cells are differentially reprogrammed in response to kinase inhibitors. 
K Hirano, S Nagata, S Yamaguchi, M Nakagawa, K Okita, H Kotera, J Ainscough and T Tada. 
Stem Cells and Development. 2012, 21(8), 1287-1298. doi:10.1089/scd.2011.0283.
Read more: 

Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development. 
K Okada, A Kamiya, K Ito, A Yanagida, H Ito, H Kondou, H Nishina, and H Nakauchi. 
Stem Cells and Development. 2012, 21(7), 1124-1133. doi:10.1089/scd.2011.0229.
Read more:
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) were procured from Axon Medchem.

* Many investigators in stem cell research often use CHIR 99021 (Axon 1386) and PD0325901 (Axon 1408) together as 2i (Axon 2128).

See publications used PD 0325901 from Axon Medchem

Please wait...