List of publications using CHIR99021 (Axon 1386) purchased from Axon Medchem

(Total 1002 publication citations listed from 2009 up to December 2023)

2023 (127 citations)
Oldak, B., Wildschutz, E., Bondarenko, V., & Hanna, J. H. (2023). Generation of bona fide fully integrated human post-implantation structured embryo models (SEM) derived ex utero solely from genetically unmodified naïve (HENSM) pluripotent stem cells.
* 7i from Axon Medchem, incl GO6983, PD0325901, CGP77675, Y27632, BIR796, A83-01, CHIR99021.

van der Veer, B. K., Chen, L., Custers, C., Athanasouli, P., Schroiff, M., Cornelis, R., ... & Koh, K. P. (2023). Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation. Nucleic Acids Research, 51(11), 5469-5498.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Coppiello, G., Barlabe, P., Moya-Jódar, M., Abizanda, G., Pogontke, C., Barreda, C., ... & Aranguren, X. L. (2023). Generation of heart and vascular system in rodents by blastocyst complementation. Developmental Cell, 58(24), 2881-2895.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Ensinck, I., Sideri, T., Modic, M., Capitanchik, C., Vivori, C., Toolan-Kerr, P., & van Werven, F. J. (2023). m6A-ELISA, a simple method for quantifying N6-methyladenosine from mRNA populations. RNA, 29(5), 705-712.

Cai, D., Wang, X., Sun, Y., Fan, H., Zhou, J., Yang, Z., ... & Liang, P. (2023). Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome. Stem Cell Research & Therapy, 14(1), 241.

Windt, L. M., Wiendels, M., Dostanić, M., Bellin, M., Sarro, P. M., Mastrangeli, M., ... & van Meer, B. J. (2023). Miniaturized engineered heart tissues from hiPSC-derived triple cell type co-cultures to study human cardiac function. Biochemical and Biophysical Research Communications, 681, 200-211.

Tong, K., Bandari, M., Carrick, J. N., Zenkevich, A., Kothari, O. A., Shamshad, E., ... & Verzi, M. P. (2023). In Vitro Organoid-Based Assays Reveal SMAD4 Tumor-Suppressive Mechanisms for Serrated Colorectal Cancer Invasion. Cancers, 15(24), 5820.

Aoi, T., Tanaka, A., Furuhashi, K., Ikeya, M., Shimizu, A., Arioka, Y., ... & Maruyama, S. (2023). < Editors’ Choice> Mesenchymal stem/stromal cells generated from induced pluripotent stem cells are highly resistant to senescence. Nagoya Journal of Medical Science, 85(4), 682.

Barnhoorn, S., Milanese, C., Li, T., Dons, L., Ghazvini, M., Farina, S., ... & Mastroberardino, P. G. (2023). Orthogonal analysis of mitochondrial function in Parkinson's disease patients. bioRxiv, 2023-07.

Hoetker, M. S., Yagi, M., Di Stefano, B., Langerman, J., Cristea, S., Wong, L. P., ... & Hochedlinger, K. (2023). H3K36 methylation maintains cell identity by regulating opposing lineage programmes. Nature cell biology, 25(8), 1121-1134.

Hornung, B. V., Azmani, Z., den Dekker, A. T., Oole, E., Ozgur, Z., Brouwer, R. W., ... & van IJcken, W. F. (2023). Comparison of Single Cell Transcriptome Sequencing Methods: Of Mice and Men. Genes, 14(12), 2226.

Naito, Y., Sakamoto, S., Kojima, T., Homma, M., Tanaka, M., & Matsui, H. (2023). Novel beta-glucocerebrosidase chaperone compounds identified from cell-based screening reduce pathologically accumulated glucosylsphingosine in iPS-derived neuronal cells. SLAS Discovery, 28(7), 344-349.
* CHIR99021 and LDN193189 from Axon Medchem

Arboit, M., Zorzan, I., Pellegrini, M., Martini, P., Carbognin, E., & Martello, G. (2023). KLF7 is a general inducer of human pluripotency. bioRxiv, 2023-09.
* 7i: PD0325901, Y27632, XAV939, GO6983, CHIR99021, A83-01, SB432541 from Axon Medchem

Sun, Y., Su, J., Wang, X., Wang, J., Guo, F., Qiu, H., ... & Jiang, C. (2023). Patient-specific iPSC-derived cardiomyocytes reveal variable phenotypic severity of Brugada syndrome. EBioMedicine, 95.

Chien, Y., Huang, X. Y., Chien, C. S., Yarmishyn, A., Liu, Y. H., Hsiao, Y. J., ... & Chiou, G. Y. (2023). Paracrinal Regulation of Neutrophil Functions by Coronaviral Infection in Ipsc-Derived Alveolar Type Ii Epithelial Cells. Available at SSRN 4537785.

Oldak, B., Wildschutz, E., Bondarenko, V., Comar, M. Y., Zhao, C., Aguilera-Castrejon, A., ... & Hanna, J. H. (2023). Complete human day 14 post-implantation embryo models from naive ES cells. Nature, 622(7983), 562-573.
* 7i from Axon Medchem, incl GO6983, PD0325901, CGP77675, Y27632, BIR796, A83-01, CHIR99021.

Ugur, E. (2023). Porte,. de la. Qin, WH, Bultmann, S., I ano a,., Drukker, ME,… Leonhardt, H.
*2i: PD0325901 and CHIR99021 from Axon Medchem.

Supakul, S., Hatakeyama, Y., Leventoux, N., Itsuno, M., Numata, N., Hiramine, H., ... & Okano, H. (2023). Urine-derived cells from the aged donor for the 2D/3D modeling of neural cells via iPSCs. Aging Brain, 4, 100101.

Farkas, K., & Ferretti, E. (2023). Derivation of Human Extraembryonic Mesoderm-like Cells from Primitive Endoderm. International Journal of Molecular Sciences, 24(14), 11366.
* CHIR99021, PIK90 and C59 from Axon Medchem

Carido, M., Völkner, M., Steinheuer, L. M., Wagner, F., Kurth, T., Dumler, N., ... & Karl, M. O. (2023). Reliability of human retina organoid generation from hiPSC-derived neuroepithelial cysts. Frontiers in Cellular Neuroscience, 17.

Klug, K., Spitzel, M., Hans, C., Klein, A., Schottmann, N. M., Erbacher, C., & Üçeyler, N. (2023). Endothelial Cell Dysfunction and Hypoxia as Potential Mediators of Pain in Fabry Disease: A Human-Murine Translational Approach. International Journal of Molecular Sciences, 24(20), 15422.

Costamagna, D., Bastianini, V., Corvelyn, M., Duelen, R., Deschrevel, J., De Beukelaer, N., ... & Desloovere, K. (2023). Botulinum Toxin Treatment of Adult Muscle Stem Cells from Children with Cerebral Palsy and HiPSC-Derived Neuromuscular Junctions. Cells, 12(16), 2072.

Guidotti, G., Duelen, R., Bloise, N., Soccio, M., Gazzano, M., Aluigi, A., ... & Lotti, N. (2023). The ad hoc chemical design of random PBS-based copolymers influences the activation of cardiac differentiation while altering the HYPPO pathway target genes in hiPSCs. Biomaterials Advances, 154, 213583.

Yadav, S., Fujimoto, K., Takenaga, T., Takahashi, S., Muramoto, Y., Mikawa, R., ... & Yokokawa, R. (2023). Isogenic iPSC-derived proximal and distal lung-on-chip models: Tissue-and virus-specific immune responses in human lungs. bioRxiv, 2023-11.

Ferlazzo, G. M., Gambetta, A. M., Amato, S., Cannizzaro, N., Angiolillo, S., Arboit, M., ... & Martello, G. (2023). Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity. Nature Communications, 14(1), 3962.
* 4i from Axon Medchem, including CHIR99021, PD0325901, SB431542 and Y-27632

Correia, B., Sousa, M. I., & Ramalho-Santos, J. (2023). Metabolic Effects on Mouse Embryonic Stem Cells and the Canonical Mammalian Target of Rapamycin Pathway. BioChem, 3(4), 170-181.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Doni, D., Cavion, F., Bortolus, M., Baschiera, E., Muccioli, S., Tombesi, G., ... & Costantini, P. (2023). Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain. Cell Death & Disease, 14(12), 805.

Carbognin, E., Carlini, V., Panariello, F., Chieregato, M., Guerzoni, E., Benvegnù, D., ... & Martello, G. (2023). Esrrb guides naive pluripotent cells through the formative transcriptional programme. Nature cell biology, 25(5), 643-657.
* 4i from Axon Medchem, including PD0325901, CHIR99021, XAV939 and Y-27632.

van der Wal, E., Iuliano, A., LM, S., Bholasing, A. P., Priesmann, D., Sharma, P., ... & de Greef, J. C. (2023). Highly contractile 3D tissue engineered skeletal muscles from human iPSCs reveal similarities with primary myoblast-derived tissues. Stem Cell Reports, 18(10), 1954-1971.

Papadopoulou, M. A., Rogdakis, T., Charou, D., Peteinareli, M., Ntarntani, K., Gravanis, A., ... & Charalampopoulos, I. (2023). Neurotrophin analog ENT-A044 activates the p75 neurotrophin receptor, regulating neuronal survival in a cell context-dependent manner. International Journal of Molecular Sciences, 24(14), 11683.

Warin, J., Vedrenne, N., Tam, V., Zhu, M., Yin, D., Lin, X., ... & Camus, A. Integration of in Vitro and in Vivo Models Defines a Molecular Signature Reference for Human Embryonic Notochordal Cells.
* CHIR99021 and SB431542 from Axon Medchem

Tamura, T., Yamasoba, D., Oda, Y., Ito, J., Kamasaki, T., Nao, N., ... & Fukuhara, T. (2023). Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA. 1, BA. 2, and BA. 5. Communications Biology, 6(1), 1-12.[

Trapannone, R., Romanov, J., & Martens, S. (2023). p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons. Life Science Alliance, 6(11).
* 2i from Axon Medchem

Gökbuget, D., Lenshoek, K., Boileau, R. M., Bayerl, J., Huang, H., Wiita, A. P., ... & Blelloch, R. (2023). Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells. Nature Structural & Molecular Biology, 30(10), 1561-1570.

Mendes-Pinheiro, B., Campos, J., Marote, A., Soares-Cunha, C., Nickels, S. L., Monzel, A. S., ... & Salgado, A. J. (2023). Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration. 
Cells, 12(21), 2565.

Krüger, J. (2023). 
Modelling gastrointestinal development and disease with stem cell-derived organoids (Doctoral dissertation, Universität Ulm).

Iuliano, A., Haalstra, M., Raghuraman, R., Bielawski, K., Bholasing, A. P., van der Wal, E., ... & Pijnappel, W. P. (2023). Real‐time and Multichannel Measurement of Contractility of hiPSC‐Derived 3D Skeletal Muscle using Fiber Optics‐Based Sensing. Advanced Materials Technologies, 8(22), 2300845.

Meek, S., Singh-Dolt, K., Sutherland, L., Sharp, M. G., Del-Pozo, J., Walker, D., & Burdon, T. (2023). p75NTR neurotrophin receptor function is redundant for development, growth and fertility in the rat. bioRxiv, 2023-12.
* 2i : CHIR99021 and PD0325901 from Axon Medchem

Klein, T., Gruener, J., Breyer, M., Schlegel, J., Schottmann, N. M., Hofmann, L., ... & Uceyler, N. (2023). Small fibre neuropathy in Fabry disease: A human-derived neuronal in vitro disease model. bioRxiv, 2023-08.

Meier, A. B., Zawada, D., De Angelis, M. T., Martens, L. D., Santamaria, G., Zengerle, S., ... & Moretti, A. (2023). Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease. Nature Biotechnology, 41(12), 1787-1800.

Aizawa, E., Ozonov, E. A., Kawamura, Y. K., Dumeau, C. E., Nagaoka, S., Kitajima, T. S., ... & Wutz, A. (2023). Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes. The EMBO Journal, 42(23), e113955.
* 2i from Axon Medchem

Fujimori, T., Rios-Martinez, C., Thurm, A. R., Hinks, M. M., Doughty, B. R., Sinha, J., ... & Bintu, L. (2023). Single-cell chromatin state transitions during epigenetic memory formation. bioRxiv.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Mulas, C., Stammers, M., Salomaa, S. I., Heinzen, C., Suter, D. M., Smith, A., & Chalut, K. J. (2023). ERK signalling orchestrates metachronous transition from naive to formative pluripotency. bioRxiv, 2023-07.
*CHIR99021, PD0325901 and BI-D1870 from Axon Medchem

Spreng, A. S. (2023). Generation and functional characterization of specific astrocyte subpopulations.

EPS, E. P. S. (2023). Real-time and Multichannel Measurement of Contractility of hiPSC-Derived 3D Skeletal Muscle using Fiber Optics-Based Sensing.

Vitale, M. R. (2023). Excitatory/inhibitory balance in iPSC-derived glutamatergic/GABAergic neuronal networks: differential Cadherin-13 genotype effects (Doctoral dissertation, Universität Würzburg).

Rosowski, S., Remmert, C., Marder, M., Akishiba, M., Bushe, J., Feuchtinger, A., ... & Meier, M. (2023). Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment. Stem Cell Reports, 18(10), 1972-1986.

Nakashima, Y., Iguchi, H., Shimizu, E., Le, M. N., Takakura, K., Nakamura, Y., ... & Tsukahara, M. (2023). Improved production of induced pluripotent stem cells using dot pattern culture plates. Tissue Engineering Part C: Methods, 29(9), 410-423.

Krishna, A., Meynert, A., Kelder, M., Ewing, A., Sheraz, S., Ferrer-Vacquer, A., ... & Ozdemir, D. D. (2023). Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits. bioRxiv, 2023-11.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Yoshimatsu, S., Nakajima, M., Sonn, I., Natsume, R., Sakimura, K., Nakatsukasa, E., ... & Okano, H. (2023). Attempts for deriving extended pluripotent stem cells from common marmoset embryonic stem cells. Genes to Cells, 28(2), 156-169.

Etxaniz Díaz de Durana, J. (2023). A Comparative Study Of Cell Culture Conditions During Conversion From Primed To Naive Human Pluripotent Stem Cells.
* CHIR99021, PD0325901, SP600125, BIRB796, Y-27632 and GO6983 from Axon Medchem

Mergani, A., Meurer, M., Wiebe, E., Dümmer, K., Wirz, K., Lehmann, J., ... & Seeger, B. (2023). Alteration of cholesterol content and oxygen level in intestinal organoids after infection with Staphylococcus aureus. The FASEB Journal, 37(12), e23279.

Iwatsuki, K., Oikawa, M., Kobayashi, H., Penfold, C. A., Sanbo, M., Yamamoto, T., ... & Kobayashi, T. (2023). Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells. Cell Reports Methods, 3(8).
*2i: CHIR99021 and PD0325901 from Axon Medchem

Beydag-Tasöz, B. S., D’Costa, J. V., Hersemann, L., Lee, B. H., Luppino, F., Kim, Y. H., ... & Grapin-Botton, A. (2023). Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors. Developmental Cell, 58(21), 2292-2308.

Zagare, A. (2023). Contribution of Type 2 Diabetes and genetic variants in LRRK2 and GBA to Parkinson's disease.

Cernko, M. T. Human induced pluripotent stem cell-derived β cells as model to investigate the role of genetic risk and environmental insults in the pathogenesis of type 2 diabetes.

Zagare, A., Preciat, G., Nickels, S. L., Luo, X., Monzel, A. S., Gomez-Giro, G., ... & Schwamborn, J. C. (2023). Omics data integration suggests a potential idiopathic Parkinson’s disease signature. Communications Biology, 6(1), 1179.

Cazottes, E., Alfeghaly, C., Rognard, C., Loda, A., Castel, G., Villacorta, L., ... & Rougeulle, C. (2023). Extensive remodelling of XIST regulatory networks during primate evolution. bioRxiv, 2023-12.

Chemla, A., Arena, G., Sacripanti, G., Barmpa, K., Zagare, A., Garcia, P., ... & Saraiva, C. (2023). Parkinson's disease-related Miro1 mutation induces mitochondrial dysfunction and loss of dopaminergic neurons in vitro and in vivo. bioRxiv, 2023-12.

Schüle, K. M., Weckerle, J., Probst, S., Wehmeyer, A. E., Zissel, L., Schröder, C. M., ... & Arnold, S. J. (2023). Eomes restricts Brachyury functions at the onset of mouse gastrulation. Developmental Cell, 58(18), 1627-1642.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Hosokawa, M., Mikawa, R., Hagiwara, A., Okuno, Y., Awaya, T., Yamamoto, Y., ... & Hagiwara, M. (2023). Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC. Iscience, 26(10).

Papadopoulou, M. A., Rogdakis, T., Charou, D., Peteinareli, M., Ntarntani, K., Gravanis, A., ... & Charalampopoulos, I. (2023). Neurotrophin Analog ENT-A044 Activates the p75 Neurotrophin Receptor Promoting Cell Death in Mouse and Human Neuronal Cells.

Katsuda, T., Sussman, J., Li, J., Merrell, A. J., Vostrejs, W. P., Secreto, A., ... & Stanger, B. Z. (2023). Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells. 
Stem cell reports, 18(7), 1436-1450.

Wenger, A., Biran, A., Alcaraz, N., Redó-Riveiro, A., Sell, A. C., Krautz, R., ... & Groth, A. (2023). Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity. Nature Genetics, 55(9), 1567-1578.

Tsujino, S., Deguchi, S., Nomai, T., Padilla-Blanco, M., Plianchaisuk, A., Wang, L., ... & Sato, K. (2023). Virological characteristics of the SARS-CoV-2 Omicron EG. 5.1 variant. bioRxiv, 2023-10.

Lee-Glover, L. P. (2023). Mitochondrial dysfunction and steroidogenesis in Parkinson disease.

Dinarello, A., Betto, R. M., Diamante, L., Tesoriere, A., Ghirardo, R., Cioccarelli, C., ... & Argenton, F. (2023). STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia. Cell Death Discovery, 9(1), 226.
* 2i from Axon Medchem

Knudsen, T. E., Hamilton, W. B., Proks, M., Lykkegaard, M., Linneberg-Agerholm, M., Nielsen, A. V., ... & Brickman, J. M. (2023). A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation. Cell Systems, 14(9), 788-805.
* 2i from Axon Medchem

Jiménez, S., Schreiber, V., Mercier, R., Gradwohl, G., & Molina, N. (2023). Characterization of cell-fate decision landscapes by estimating transcription factor dynamics. Cell Reports Methods, 3(7).

Yayli, G., Bernardini, A., Sanchez, P. K. M., Scheer, E., Damilot, M., Essabri, K., ... & Tora, L. (2023). ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct. Cell reports, 42(9).
* 2i from Axon Medchem

Argenton, F., Martello, G., Tiso, N., Dinarello, A., Betto, R., Meneghetti, G., ... & Tesoriere, A. (2023). STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Hartleb, A. (2023). Auswirkungen eines Tandem-Peptids auf den intrazellulären Kalziumhaushalt und Arrhythmien von humanen iPS-Kardiomyozyten mit Mutationen in desmosomalen Proteinen (Doctoral dissertation, Universität Würzburg).

Alonso Alonso, S. Análisis del potencial de los blastómeros del embrión de ratón a 8 células para generar células madre embrionarias.
*2i : CHIR99021 and PD0325901 from Axon Medchem

Almeida, C. F., Robriquet, F., Vetter, T. A., Huang, N., Neinast, R., Hernandez-Rosario, L., ... & Wein, N. (2023). Promising AAV. U7snRNAs vectors targeting DMPK improve DM1 hallmarks in patient-derived cell lines. Frontiers in Cell and Developmental Biology11, 1181040.

Higashitani, Y., & Horie, K. (2023). Long-read sequence analysis of MMEJ-mediated CRISPR genome editing reveals complex on-target vector insertions that may escape standard PCR-based quality control. bioRxiv, 2023-03.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Zhou, J., Cui, B., Wang, X., Wang, H., Zheng, J., Guo, F., ... & Liang, P. (2023). Overexpression of KCNJ2 enhances maturation of human-induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Research & Therapy14(1), 92.

Ugur, E., de la Porte, A., Qin, W., Bultmann, S., Ivanova, A., Drukker, M., ... & Leonhardt, H. (2023). Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components. Nucleic Acids Research51(6), 2671-2690.
* 2i : PD0325901 and CHIR99021 from Axon Medchem

Mizuno, K., Ohnishi, H., Yoshimatsu, M., Zhao, C., Hayashi, Y., Kuwata, F., ... & Omori, K. (2023). Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells. Cell Transplantation32, 09636897231178460.

Ying, H., Guo, W., Tang, X., Pan, J., Yu, P., Fan, H., ... & Liang, P. (2023). Colchicine attenuates the electrical remodeling of post-operative atrial fibrillation through inhibited expression of immune-related hub genes and stabilization of microtubules. International Journal of Biological Sciences19(9), 2934.

Sieliwonczyk, E., Alaerts, M., Simons, E., Snyders, D., Nijak, A., Vandendriessche, B., ... & Loeys, B. (2023). Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population. Orphanet Journal of Rare Diseases18(1), 1-12.

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Corridori, C., ... & Martello, G. (2023). Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation. EMBO reports24(4), e55235.
* PD0325901, XAV939, GO6983, Y27632, CHIR99021, A83-01 and SB431542 from Axon Medchem

de Jong, M. A., Adegeest, E., Bérenger-Currias, N. M., Mircea, M., Merks, R. M., & Semrau, S. (2023). A combination of convergent extension and differential adhesion explains the shapes of elongating gastruloids. bioRxiv, 2023-05.

Capinha, L., Zhang, Y., Holzer, A. K., Ückert, A. K., Zana, M., Carta, G., ... & Jennings, P. (2023). Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models. Archives of Toxicology97(2), 523-545.

Delás, M. J., Kalaitzis, C. M., Fawzi, T., Demuth, M., Zhang, I., Stuart, H. T., ... & Briscoe, J. (2023). Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies. Developmental Cell58(1), 3-17.

Ribeiro, J., & Crossan, G. P. (2023). GCNA is a histone binding protein required for spermatogonial stem cell maintenance. Nucleic Acids Research51(10), 4791-4813.
* PD0325901 and CHIR99021 from Axon Medchem

Baden, P., Perez, M. J., Raji, H., Bertoli, F., Kalb, S., Illescas, M., ... & Deleidi, M. (2023). Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism. Nature Communications14(1), 1930.

van Amerongen, R. A., Morton, L. T., Chaudhari, U. G., Remst, D. F., Hagedoorn, R. S., van den Berg, C. W., ... & Heemskerk, M. H. (2023). Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential. Molecular Therapy-Methods & Clinical Development.

Ballmer, D., Tardat, M., Ortiz, R., Graff-Meyer, A., Ozonov, E. A., Genoud, C., ... & Fanourgakis, G. (2023). HP1 proteins regulate nucleolar structure and function by secluding pericentromeric constitutive heterochromatin. Nucleic Acids Research51(1), 117-143.
* CHIR99021 and PD184352 from Axon Medchem

Sakuma, K., Tsubooka-Yamazoe, N., Hashimoto, K., Sakai, N., Asano, S., Watanabe-Matsumoto, S., ... & Toyoda, T. (2023). CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs. Stem Cell Research & Therapy14(1), 1.

Sun, J., Osenberg, S., Irwin, A., Ma, L. H., Lee, N., Xiang, Y., ... & Ballas, N. (2023). Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation. Cell Reports42(1), 111942.

Kaemena, D. F., Yoshihara, M., Beniazza, M., Ashmore, J., Zhao, S., Bertenstam, M., ... & Kaji, K. (2023). B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors. Nature Communications14(1), 488.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Schüle, K. M., Weckerle, J., Probst, S., Wehmeyer, A. E., Zissel, L., Schröder, C. M., ... & Arnold, S. J. (2023). Eomes restricts Brachyury functions at the onset of mammalian gastrulation. bioRxiv, 2023-01.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Messelodi, D., Strocchi, S., Bertuccio, S. N., Baden, P., Indio, V., Giorgi, F. M., ... & Pession, A. (2023). Neuronopathic Gaucher disease models reveal defects in cell growth promoted by Hippo pathway activation. Communications Biology6(1), 431.

Breitmeyer, R., Vogel, S., Heider, J., Hartmann, S. M., Wüst, R., Keller, A. L., ... & Volkmer, H. (2023). Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction. Communications Biology6(1), 472.

Ito, R., Kimura, A., Hirose, Y., Hatano, Y., Mima, A., Mae, S. I., ... & Osafune, K. (2023). Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model. Scientific Reports13(1), 8659.

Ensinck, I., Sideri, T., Modic, M., Capitanchik, C., Vivori, C., Toolan-Kerr, P., & van Werven, F. J. (2023). m6A-ELISA, a simple method for quantifying N6-methyladenosine from mRNA populations. RNA29(5), 705-712.

Park, P. J., & Christopher, C. A. W. Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory 2 elements 3.

Sambri, I., Ferniani, M., Campostrini, G., Testa, M., Meraviglia, V., de Araujo, M. E., ... & Ballabio, A. (2023). RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nature Communications14(1), 2775.

Linneberg-Agerholm, M., Sell, A. C., Redo-Riveiro, A., Proks, M., Knudsen, T. E., Perera, M., & Brickman, J. M. (2023). Enhancer status in the primitive endoderm supports unrestricted lineage plasticity in regulative development. bioRxiv, 2023-05.

Meier, A. B., Zawada, D., De Angelis, M. T., Martens, L. D., Santamaria, G., Zengerle, S., ... & Moretti, A. (2023). Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease. Nature Biotechnology, 1-14.

Arena, G., Landoulsi, Z., Grossmann, D., Vitali, A., Delcambre, S., Baron, A., ... & Gruenewald, A. (2023). Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson's disease. medRxiv, 2023-05.

van der Veer, B. K., Chen, L., Custers, C., Athanasouli, P., Schroiff, M., Cornelis, R., ... & Koh, K. P. (2023). Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation. Nucleic Acids Research, gkad231.

Rivera‐Arbeláez, J. M., Keekstra, D., Cofiño‐Fabres, C., Boonen, T., Dostanic, M., Ten Den, S. A., ... & Passier, R. (2023). Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking. Bioengineering & Translational Medicine, e10513.

Jones, C., Avino, M., Giroux, V., & Boudreau, F. (2023). HNF4α acts as upstream functional regulator of intestinal Wnt3 and paneth cell fate. Cellular and Molecular Gastroenterology and Hepatology15(3), 593-612.

Arena, G., Landoulsi, Z., Grossmann, D., Vitali, A., Delcambre, S., Baron, A., ... & Grünewald, A. (2023). Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson\textquoterights disease 2023.05. 12.23289877.

Dane, T. L., Gill, A. L., Vieira, F. G., & Denton, K. R. (2023). Reduced C9orf72 expression exacerbates polyGR toxicity in patient iPSC-derived motor neurons and a Type I protein arginine methyltransferase inhibitor reduces that toxicity. Frontiers in Cellular Neuroscience17, 1134090.

Hermann, F. M., Kjærgaard, M. F., Tian, C., Tiemann, U., Jackson, A., Olsen, L. R., ... & Semb, H. (2023). An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells. Cell Stem Cell30(1), 38-51.
* CHIR99021 and R428 from Axon Medchem

van Royen, M. E., IJcken, W. F. J., French, P., Bedalov, A., & Gribnau, J. H. Mira-Bontenbal,* B. Tan, C. Gontan, S. Goossens, RG Boers, JB Boers, C. Dupont.

Tamura, T., Ito, J., Uriu, K., Zahradnik, J., Kida, I., Anraku, Y., ... & Sato, K. (2023). Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants. Nature communications14(1), 2800.

Kranaster, P., Blum, J., Dold, J. E., Wittmann, V., & Leist, M. (2023). Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells. Journal of Neurochemistry164(4), 481-498.

Lechado-Terradas, A., Schepers, S., Zittlau, K. I., Sharma, K., Ok, O., Fitzgerald, J. C., ... & Kahle, P. J. (2022). Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy. Autophagy Reports1(1), 576-602.

Ito, J., Suzuki, R., Uriu, K., Itakura, Y., Zahradnik, J., Kimura, K. T., ... & Sato, K. (2023). Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ. 1.1 variant. Nature communications14(1), 2671.

Patberg, M., Oniani, T., Disse, P., Peischard, S., Vinnenberg, L., Zobeiri, M., ... & Junker, A. (2023). Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18. Archiv der Pharmazie356(6), 2200665.

Tasca, F. Shepherding precision gene editing ith CRISPR-Cas9 ariants and adeno iral ectors.

Katsuda, T., Li, J., Merrell, A. J., Sussman, J., Matsuzaki, J., Ochiya, T., & Stanger, B. Z. (2023). Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells. bioRxiv, 2023-01.

Gil, N., Perry, R. B. T., Mukamel, Z., Tuck, A., Bühler, M., & Ulitsky, I. (2023). Complex regulation of Eomes levels mediated through distinct functional features of the Meteor long non-coding RNA locus. Cell Reports42(6).
* PD0325901, CHIR99021 and Y27632 from Axon Medchem

Sierra-Delgado, J. A., Sinha-Ray, S., Kaleem, A., Ganjibakhsh, M., Parvate, M., Powers, S., ... & Meyer, K. (2023). In Vitro Modeling as a Tool for Testing Therapeutics for Spinal Muscular Atrophy and IGHMBP2-Related Disorders. Biology12(6), 867.

Zittlau, K. I. (2023). Temporal analysis of parkin-dependent mitophagy using mass spectrometry-based proteomics(Doctoral dissertation, Universität Tübingen).

Robertson, F. L., O’Duibhir, E., Gangoso, E., Bressan, R. B., Bulstrode, H., Marqués-Torrejón, M. Á., ... & Pollard, S. M. (2023). Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/β-catenin to induce exit from quiescence. Cell Reports42(6).

Schwarz, L. (2023). Miro1-mutant iPSC-derived Neurons reveal novel functions of Miro1 in mitochondrial respiration and dopamine handling (Doctoral dissertation, Universität Tübingen).
* dorsomorphin and CHIR99021 from Axon medchem

Sinenko, S. A., Kuzmin, A. A., Skvortsova, E. V., Ponomartsev, S. V., Efimova, E. V., Bader, M., ... & Tomilin, A. N. (2023). Tryptophan hydroxylase-2-mediated serotonin biosynthesis suppresses cell reprogramming into pluripotent state. International Journal of Molecular Sciences24(5), 4862.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Zujur, D., Al-Akashi, Z., Nakamura, A., Zhao, C., Takahashi, K., Aritomi, S., ... & Ikeya, M. (2023). Enhanced chondrogenic differentiation of iPS cell-derived mesenchymal stem/stromal cells via neural crest cell induction for hyaline cartilage repair. Frontiers in Cell and Developmental Biology11, 1140717.

Miyashita, R., Nishiyama, A., Qin, W., Chiba, Y., Kori, S., Kato, N., ... & Nakanishi, M. (2023). The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Elife12, e79013.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Γκουγκούσης, Χ. (2023). Πρωτεωμικός χαρακτηρισμός καρδιομυοκυττάρων προερχόμενων από εμβρυονικά βλαστικά κύτταρα ανθρώπου (Master's thesis).Μ.Ε.%20ΓΚΟΥΓΚΟΥΣΗΣ%20ΧΡΗΣΤΟΣ%202023.pdf

Sato, S., Hishida, T., Kinouchi, K., Hatanaka, F., Li, Y., Nguyen, Q., ... & Sassone-Corsi, P. (2023). The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming. Cell Reports42(6).
* CHIR99021 and SB202190 from Axon Medchem

Bernardini, A., Mukherjee, P., Scheer, E., Kamenova, I., Antonova, S., Sanchez, P. K. M., ... & Tora, L. (2023). Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID. bioRxiv, 2023-04.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Luna Velez, M. V., Neikes, H. K., Snabel, R. R., Quint, Y., Qian, C., Martens, A., ... & Vermeulen, M. (2023). ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study. Nucleic Acids Research.

Noviello, G., Gjaltema, R. A., & Schulz, E. G. (2023). CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. Nature Communications14(1), 3225.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

2022 (121 citations)
Romayor, I., Herrera, L., Burón, M., Martin-Inaraja, M., Prieto, L., Etxaniz, J., ... & Eguizabal, C. (2022). A Comparative Study of Cell Culture Conditions during Conversion from Primed to Naive Human Pluripotent Stem Cells. Biomedicines10(6), 1358.
* CHIR99021, PD0325901, Y27632, Go6983, SP600125 and BIRB796 from Axon Medchem

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Martini, P., & Martello, G. (2022). Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. bioRxiv, 2022-04.
*PD0325901, XAV939, Go6983, Y27632, CHIR99021, A83-01, SB431542 from Axon Medchem

Viukov, S., Shani, T., Bayerl, J., Sheban, D., Stelzer, Y., Novershtern, N., & Hanna, J. H. (2022). Human primed and naïve PSCs are both competent in differentiating into bona fide trophoblast stem cells. BioRxiv, 2022-05.
*PD0325901, XAV939, GO6983, CGP77675, BIRB796, A883-01, CHIR99021, Y27632 from Axon Medchem

Takao, T., Yamada, D., & Takarada, T. (2022). A protocol to induce expandable limb-bud mesenchymal cells from human pluripotent stem cells. STAR protocols3(4), 101786.

Marini, V., Marino, F., Aliberti, F., Giarratana, N., Pozzo, E., Duelen, R., ... & Chai, Y. C. (2022). Long-term culture of patient-derived cardiac organoids recapitulated Duchenne muscular dystrophy cardiomyopathy and disease progression. Frontiers in Cell and Developmental Biology10, 878311.

Tada, T., Ohnishi, H., Yamamoto, N., Kuwata, F., Hayashi, Y., Okuyama, H., ... & Omori, K. (2022). Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats. Regenerative Therapy19, 77-87.

Montero-Calle, P., Flandes-Iparraguirre, M., Mountris, K., S de la Nava, A., Laita, N., Rosales, R. M., ... & Mazo, M. M. (2022). Fabrication of human myocardium using multidimensional modelling of engineered tissues. Biofabrication14(4), 045017.
* CHIR99021 and C59 from Axon Medchem

Viegas, J. O., Azad, G. K., Lv, Y., Fishman, L., Paltiel, T., Pattabiraman, S., ... & Meshorer, E. (2022). RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2. Developmental Cell57(24), 2731-2744.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Kuwata, F., Ohnishi, H., Yamamoto, N., Takezawa, T., Yamashita, M., Okuyama, H., ... & Omori, K. (2022). Transplantation of Human Induced Pluripotent Stem Cell-Derived Airway Cells on Vitrigel Membrane into Rat Nasal Cavity. Tissue Engineering Part A28(13-14), 586-594.

Stolz, P., Mantero, A. S., Tvardovskiy, A., Ugur, E., Wange, L. E., Mulholland, C. B., ... & Bultmann, S. (2022). TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation. Nucleic Acids Research50(15), 8491-8511.
*2i; PD0325901 and CHIR99021 from Axon Medchem

Cao, X., Mircea, M., Yakala, G. K., van den Hil, F. E., Brescia, M., Mei, H., ... & Orlova, V. V. (2023). ETV2 upregulation marks the specification of early cardiomyocytes and endothelial cells during co-differentiation. Stem Cells41(2), 140-152.

Tarazi, S., Aguilera-Castrejon, A., Joubran, C., Ghanem, N., Ashouokhi, S., Roncato, F., ... & Hanna, J. H. (2022). Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell185(18), 3290-3306.
* CHIR99021, PD0325901, Y27632 from Axon Medchem

Rousset, F., Schilardi, G., Sgroi, S., Nacher-Soler, G., Sipione, R., Kleinlogel, S., & Senn, P. (2022). WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro. Cells11(15), 2431.
* CHIR99021, LND193189 and SB431542 from Axon Medchem

Miura, Y., Sato, M., Kuwahara, T., Ebata, T., Tabata, Y., & Sakurai, H. (2022). Transplantation of human iPSC-derived muscle stem cells in the diaphragm of Duchenne muscular dystrophy model mice. Plos one17(4), e0266391.

Peischard, S., Möller, M., Disse, P., Ho, H. T., Verkerk, A. O., Strutz-Seebohm, N., ... & Seebohm, G. (2022). Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system. Cellular and Molecular Life Sciences79(8), 440.
* CHIR99021 and CID 1067700 (ML282) from Axon Medchem

Girard, O., Lavigne, R., Chevolleau, S., Onfray, C., Com, E., Schmit, P. O., ... & Pineau, C. (2022). Naive Pluripotent and Trophoblastic Stem Cell Lines as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project. Journal of proteome research.
* PD0325901, XAV939, GO6983, Y27632 and CHIR99021 from Axon Medchem

Kuwata, F. (2022). Transplantation of human iPS cell-derived airway cells on vitrigel membrane into rat nasal cavity.

Alonso-Alonso, S., Santaló, J., & Ibáñez, E. (2022). Efficient generation of embryonic stem cells from single blastomeres of cryopreserved mouse embryos in the presence of signalling modulators. Reproduction, Fertility and Development34(7), 576-587.
* 2i : PD0325901 and CHIR99021 from Axon Medchem

Trikalitis, V. D., Kroese, N. J., Kaya, M., Cofiño-Fabres, C., Ten Den, S., Khalil, I. S., ... & Rouwkema, J. (2022). Embedded 3D printing of dilute particle suspensions into dense complex tissue fibers using shear thinning xanthan baths. Biofabrication15(1), 015014.

Luquette, L. J., Miller, M. B., Zhou, Z., Bohrson, C. L., Zhao, Y., Jin, H., ... & Park, P. J. (2022). Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements. Nature Genetics54(10), 1564-1571.
*2i; PD0325901 and CHIR99021 from Axon Medchem

Pham, T. X. A., Panda, A., Kagawa, H., Ertekin, C., Georgolopoulos, G., van Knippenberg, S. S., ... & Pasque, V. (2022). Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells. Cell Stem Cell29(9), 1346-1365.
* PD0325901, SB431542, CHIR99021, from Axon Medchem

Wakimizu, T., Morikawa, K., Fukumura, K., Yuki, T., Adachi, T., Kurata, Y., ... & Shirayoshi, Y. (2022). SHOX2 refines the identification of human sinoatrial nodal cell population in the in vitro cardiac differentiation. Regenerative Therapy21, 239-249.

Coppiello, G., Barlabe, P., Moya-Jodar, M., Abizanda, G., Barreda, C., Iglesias, E., ... & Aranguren, X. L. (2022). In vivo generation of heart and vascular system by blastocyst complementation. bioRxiv, 2022-10.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Hiltunen, A. E., Vuolteenaho, R., Ronkainen, V. P., Miinalainen, I., Uusimaa, J., Lehtonen, S., & Hinttala, R. (2022). Nhlrc2 is crucial during mouse gastrulation. genesis60(3), e23470.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Rivera-Arbeláez, J. M., Cofiño-Fabres, C., Schwach, V., Boonen, T., Ten Den, S. A., Vermeul, K., ... & Passier, R. (2022). Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application. Plos one17(4), e0266834.

Gu, Y., Zhou, Y., Ju, S., Liu, X., Zhang, Z., Guo, J., ... & Hu, Z. (2022). Multi-omics profiling visualizes dynamics of cardiac development and functions. Cell Reports41(13), 111891.

Zagare, A., Barmpa, K., Smajic, S., Smits, L. M., Grzyb, K., Grünewald, A., ... & Schwamborn, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p. Gly2019Ser-associated gene expression. The American Journal of Human Genetics109(2), 311-327.

van Neerven, S. M., Smit, W. L., van Driel, M. S., Kakkar, V., de Groot, N. E., Nijman, L. E., ... & Vermeulen, L. (2022). Intestinal Apc‐inactivation induces HSP25 dependency. EMBO Molecular Medicine, e16194.

Tamai, K., Sakai, K., Yamaki, H., Moriguchi, K., Igura, K., Maehana, S., ... & Gotoh, S. (2022). iPSC-derived mesenchymal cells that support alveolar organoid development. Cell Reports Methods2(10), 100314.

Cao, X., & Mircea, M. (2022). akala, GK, Hil, FE an den, Brescia, M. Mei, HL,… Orlo a5, 140-152.

Kwok, C. K., Sébastien, I., Hariharan, K., Meiser, I., Wihan, J., Altmaier, S., ... & Zimmermann, H. (2022). Scalable expansion of iPSC and their derivatives across multiple lineages. Reproductive Toxicology112, 23-35.

Hauth, A., Galupa, R., Servant, N., Villacorta, L., Hauschulz, K., van Bemmel, J. G., ... & Heard, E. (2022). Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C. JoVE (Journal of Visualized Experiments), (188), e64166.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Bérenger-Currias, N. M., Mircea, M., Adegeest, E., van den Berg, P. R., Feliksik, M., Hochane, M., ... & Semrau, S. (2022). A gastruloid model of the interaction between embryonic and extra-embryonic cell types. Journal of Tissue Engineering13, 20417314221103042.

Dekel, C., Morey, R., Hanna, J., Laurent, L. C., Ben-Yosef, D., & Amir, H. (2022). Stabilization of hESCs in two distinct substates along the continuum of pluripotency. Iscience25(12), 105469.
* CHIR99021, PD0325901, BIRB796, CGP77675 and Y27632 from Axon Medchem

Kamiya, D., Takenaka-Ninagawa, N., Motoike, S., Kajiya, M., Akaboshi, T., Zhao, C., ... & Ikeya, M. (2022). Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage. npj Regenerative Medicine7(1), 47.

Higa, T., Okita, Y., Matsumoto, A., Nakayama, S., Oka, T., Sugahara, O., ... & Nakayama, K. I. (2022). Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium. Nature communications13(1), 1500.

López-Muneta, L., Linares, J., Casis, O., Martínez-Ibáñez, L., González Miqueo, A., Bezunartea, J., ... & Carvajal-Vergara, X. (2022). Generation of NKX2. 5GFP reporter human iPSCs and differentiation into functional cardiac fibroblasts. Frontiers in Cell and Developmental Biology9, 3669.

Blanch-Asensio, A., Grandela, C., Brandão, K. O., de Korte, T., Mei, H., Ariyurek, Y., ... & Davis, R. P. (2022). STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells. Cell Reports Methods2(10), 100300.

Spreng, A. S., Brüll, M., Leisner, H., Suciu, I., & Leist, M. (2022). Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation. Cells 2022, 11, 2644.

Yue, Z. H. O. U., Chen, C. H. E. N. G., Enlin, Z. H. E. N. G., Zhuo, M. E. N. G., Jian, W. A. N. G., Qingjie, W. A. N. G., & Yongning, H. E. (2022). Exploring potential new receptors for ELABELA in human embryonic stem cells by Crispr/Cas9-mediated gene editing system. Journal of Shanghai Jiao Tong University (Medical Science)42(9), 1258.

Yoshida, Y., Takahashi, M., Yamanishi, H., Nakazawa, Y., Kishimoto, J., & Ohyama, M. (2022). Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss. International Journal of Molecular Sciences23(13), 7125.

Zijlmans, D. W., Talon, I., Verhelst, S., Bendall, A., Van Nerum, K., Javali, A., ... & Pasque, V. (2022). Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nature Cell Biology24(6), 858-871.
* PD0325901, CHIR99021 and SB431542 from Axon Medchem

Costamagna, D., Casters, V., Beltrà, M., Sampaolesi, M., Van Campenhout, A., Ortibus, E., ... & Duelen, R. (2022). Autologous iPSC-Derived Human Neuromuscular Junction to Model the Pathophysiology of Hereditary Spastic Paraplegia. Cells11(21), 3351.

Li, J., Wiesinger, A., Fokkert, L., Boukens, B. J., Verkerk, A. O., Christoffels, V. M., ... & Devalla, H. D. (2022). Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models. Journal of Tissue Engineering13, 20417314221127908.

Tasca, F., Brescia, M., Wang, Q., Liu, J., Janssen, J. M., Szuhai, K., & Gonçalves, M. A. (2022). Large-scale genome editing based on high-capacity adenovectors and CRISPR-Cas9 nucleases rescues full-length dystrophin synthesis in DMD muscle cells. Nucleic Acids Research50(13), 7761-7782.

Wu, X., Ciminieri, C., Bos, I. S. T., Woest, M. E., D'Ambrosi, A., Wardenaar, R., ... & Gosens, R. (2022). Diesel exhaust particles distort lung epithelial progenitors and their fibroblast niche. Environmental Pollution305, 119292.

Tamura, T., Yamasoba, D., Oda, Y., Ito, J., Kamasaki, T., Nao, N., ... & Fukuhara, T. (2022). Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA. 1, BA. 2, and BA. 5. bioRxiv, 2022-08.

Choy Buentello, D., Koch, L. S., Trujillo-de Santiago, G., Alvarez, M. M., & Broersen, K. (2022). Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies. Plos one17(5), e0262062.

Smith, A. S., Luttrell, S. M., Dupont, J. B., Gray, K., Lih, D., Fleming, J. W., ... & Mack, D. L. (2022). High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing. Journal of Tissue Engineering13, 20417314221122127.

Vivas, A., van den Berg, A., Passier, R., Odijk, M., & van der Meer, A. D. (2022). Fluidic circuit board with modular sensor and valves enables stand-alone, tubeless microfluidic flow control in organs-on-chips. Lab on a Chip22(6), 1231-1243.

Hiyoshi, H., Sakuma, K., Tsubooka-Yamazoe, N., Asano, S., Mochida, T., Yamaura, J., ... & Toyoda, T. (2022). Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC. Scientific Reports12(1), 4740.

Nalbandian, M., Zhao, M., Kato, H., Jonouchi, T., Nakajima-Koyama, M., Yamamoto, T., & Sakurai, H. (2022). Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation. Life Science Alliance5(8).

Desloovere, K., Verfaillie, C. M., Sipido, K. R., Buyse, G. M., & Sampaolesi, M. Robin Duelen, Domiziana Costamagna, Guillaume Gilbert, 3 Liesbeth De Waele, 4 Nathalie Goemans, 4. Stem Cell Reports (2022),

Ozawa, M., Taguchi, J., Katsuma, K., Ishikawa-Yamauchi, Y., Kikuchi, M., Sakamoto, R., ... & Ikawa, M. (2022). Efficient simultaneous double DNA knock-in in murine embryonic stem cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid targeting for generating gene-manipulated mice. Scientific Reports12(1), 21558.

Yoshimoto, Y., Uezumi, A., Ikemoto-Uezumi, M., Tanaka, K., Yu, X., Kurosawa, T., ... & Shukunami, C. (2022). Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation. Frontiers in Cell and Developmental Biology10, 780038.

Fujisawa, Y., Ming, L., Yamada, D., Takao, T., & Takarada, T. (2022). Establishment of a human pluripotent stem cell-derived MKX-td Tomato reporter system. Stem Cell Research & Therapy13(1), 1-8.

Hata, K., Kobayashi, N., Sugimura, K., Qin, W., Haxholli, D., Chiba, Y., ... & Arita, K. (2022). Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger. Nucleic Acids Research50(21), 12527-12542.

Skvortsova, E. V., Nazarov, I. B., Tomilin, A. N., & Sinenko, S. A. (2022). Dual Mode of Mitochondrial ROS Action during Reprogramming to Pluripotency. International Journal of Molecular Sciences23(18), 10924.
* 2i; PD0325901 and CHIR99021 from Axon Medchem

Nijak, A., Simons, E., Vandendriessche, B., Van de Sande, D., Fransen, E., Sieliwończyk, E., ... & Loeys, B. L. (2022). Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes. Biology Open11(2), bio059016.

Aguilar, C., Pauzuolis, M., Pompaiah, M., Vafadarnejad, E., Arampatzi, P., Fischer, M., ... & Bartfeld, S. (2022). Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis. Nature Communications13(1), 5878.
Viukov, S., Shani, T., Bayerl, J., Aguilera-Castrejon, A., Oldak, B., Sheban, D., ... & Novershtern, N. (2022). Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells. Stem cell reports17(11), 2484-2500.
* PD0325901, XAV939, Go6983, Y27632, CGP77675, PD173074 and CHIR99021 from Axon Medchem

Vierthaler, M. A. (2022). The influence of ADCK2 on melanoma cells and during the development to melanocytic progenitors (NCCs) (Doctoral dissertation).

Harberts, J., Siegmund, M., Hedrich, C., Kim, W., Fontcuberta i Morral, A., Zierold, R., & Blick, R. H. (2022). Generation of Human iPSC‐Derived Neurons on Nanowire Arrays Featuring Varying Lengths, Pitches, and Diameters. Advanced Materials Interfaces9(24), 2200806.

Ugur, E., de la Porte, A., Bultmann, S., Drukker, M., Mann, M., Wierer, M., & Leonhardt, H. (2022). Comprehensive chromatin proteomics resolves functional phases of pluripotency. bioRxiv, 2022-08.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Kimura, I., Yamasoba, D., Tamura, T., Nao, N., Suzuki, T., Oda, Y., ... & Sato, K. (2022). Virological characteristics of the SARS-CoV-2 Omicron BA. 2 subvariants, including BA. 4 and BA. 5. Cell185(21), 3992-4007.

Delás, M. J., Kalaitzis, C. M., Fawzi, T., Demuth, M., Zhang, I., Stuart, H. T., ... & Briscoe, J. (2022). Developmental cell fate choice employs two distinct cis regulatory strategies. bioRxiv, 2022-06.

Duelen, R., Costamagna, D., Gilbert, G., De Waele, L., Goemans, N., Desloovere, K., ... & Sampaolesi, M. (2022). Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy. S

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