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Axon 1386 - Publications

List of publications using CHIR99021 (Axon 1386) purchased from Axon Medchem

(Total 762 publication citations listed from 2009 up to January 2022)
 

2022 (12 citations)
Fagerlund, I., Dougalis, A., Shakirzyanova, A., Gómez-Budia, M., Pelkonen, A., Konttinen, H., ... & Malm, T. (2022). Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids. Cells, 11(1), 124.
https://www.mdpi.com/1430004
* CHIR99021 from Axon Medchem

Sheban, D., Shani, T., Maor, R., Aguilera-Castrejon, A., Mor, N., Oldak, B., ... & Merbl, Y. (2022). SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. Molecular cell, 82(1), 106-122.
*3i: CHIR99021 + PD 0325901 + Y 27632 from Axon Medchem

Meier, A. B., Murthi, S. R., Rawat, H., Toepfer, C. N., Santamaria, G., Schmid, M., ... & Wolf, C. M. (2022). Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome. Iscience, 25(1), 103596.
* CHIR99021 from Axon Medchem

Kaemena, D. F., Yoshihara, M., Ashmore, J., Beniazza, M., Zhao, S., Bertenstam, M., ... & Kaji, K. (2022). B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening by pioneering factors. bioRxiv.
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Pazur, K., Giannios, I., Lesche, M., Rodriguez-Aznar, E., & Gavalas, A. (2022). Hoxb1 regulates distinct signaling pathways in neuromesodermal and hindbrain progenitors to promote cell survival and specification. Stem Cells.
https://academic.oup.com/stmcls/advance-article-abstract/doi/10.1093/stmcls/sxab014/6514433

Zagare, A., Barmpa, K., Smajic, S., Smits, L. M., Grzyb, K., Grünewald, A., ... & Schwamborn, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p. Gly2019Ser-associated gene expression. The American Journal of Human Genetics.
https://www.sciencedirect.com/science/article/pii/S000292972100464X

Sáez, M., Blassberg, R., Camacho-Aguilar, E., Siggia, E. D., Rand, D. A., & Briscoe, J. (2022). Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions. Cell Systems, 13(1), 12-28.
https://www.sciencedirect.com/science/article/pii/S2405471221003367
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Franck, S., Couvreu De Deckersberg, E., Bubenik, J. L., Markouli, C., Barbé, L., Allemeersch, J., ... & Karen, D. (2022). Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing. Biology open, 11(1), bio058978.
https://journals.biologists.com/bio/article/11/1/bio058978/273965/Myotonic-dystrophy-type-1-embryonic-stem-cells

Klemke, L., Blume, J. P., De Oliveira, T., & Schulz-Heddergott, R. (2022). Preparation and Cultivation of Colonic and Small Intestinal Murine Organoids Including Analysis of Gene Expression and Organoid Viability. Bio-protocol, 12(2), e4298-e4298.
https://bio-protocol.org/e4298

Yuri, S., Murase, Y., & Isotani, A. (2022). Generation of rat lungs by blastocyst complementation in Fgfr2b-deficient mouse model. bioRxiv.
https://www.biorxiv.org/content/10.1101/2022.01.05.475149v1.full

Duelen, R., Costamagna, D., Gilbert, G., De Waele, L., Goemans, N., Desloovere, K., ... & Sampaolesi, M. (2022). Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy. Stem Cell Reports.
https://www.sciencedirect.com/science/article/pii/S2213671121006585

Ribeiro, M. C., Rivera-Arbeláez, J. M., Cofiño-Fabres, C., Schwach, V., Slaats, R. H., Den, S. A. T., ... & Passier, R. (2022). A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues. Journal of Personalized Medicine, 12(2), 214.
https://www.mdpi.com/2075-4426/12/2/214

2021 (113 citations)
Di Stefano, B., & Hochedlinger, K. Reduced MEK inhibition preserves genomic stability in naïve human ES cells. Protocol Exchange, doi, 10. posted 2018, online 2021
https://assets.researchsquare.com/files/nprot-6829/v1/eb3f5184-8291-4206-8e0d-6ed902bce15f.pdf
* CHIR99021, PD 0325901, IM-12, Y 27632, Go 6983, SB 590885, WH-4-023 from Axon Medchem

Ikeo, S., Yamamoto, Y., Ikeda, K., Sone, N., Korogi, Y., Tomiyama, L., ... & Gotoh, S. (2021). Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo. Biomaterials, 276, 121031.
Tam, W. L., Freitas Mendes, L., Chen, X., Lesage, R., Van Hoven, I., Leysen, E., ... & Luyten, F. P. (2021). Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects. Stem cell research & therapy, 12(1), 1-16.
* CHIR99021 and BIO from Axon Medchem
 
Bayerl, J., Ayyash, M., Shani, T., Manor, Y. S., Gafni, O., Massarwa, R., ... & Hanna, J. H. (2021). Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell Stem Cell.
* CHIR99021 and 14i from Axon Medchem (including PD0325901, IWR1, BIR0796, Go6983, Y27632, CGP77675, RIN1, LDN193189, A83-01, SB590885, BIX02189, RU-SKI43, BIX01294.

Fischer, V., Scheer, E., Lata, E., Morlet, B., Plassard, D., Vincent, S. D., ... & Tora, L. (2021). SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells. bioRxiv.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Zagare, A., Gobin, M., Monzel, A. S., & Schwamborn, J. C. (2021). A robust protocol for the generation of human midbrain organoids. STAR protocols, 2(2), 100524.
Qin, W., Ugur, E., Mulholland, C. B., Bultmann, S., Solovei, I., Modic, M., ... & Leonhardt, H. (2021). Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency. Nucleic acids research, 49(13), 7406-7423.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Hall, G. N., Tam, W. L., Andrikopoulos, K. S., Casas-Fraile, L., Voyiatzis, G. A., Geris, L., ... & Papantoniou, I. (2021). Patterned, organoid-based cartilaginous implants exhibit zone specific functionality forming osteochondral-like tissues in vivo. Biomaterials, 273, 120820.
Kuwata, F., Ohnishi, H., Yamamoto, N., Takezawa, T., Yamashita, M., Okuyama, H., ... & Omori, K. (2021). Transplantation of human iPS cell-derived airway cells on vitrigel membrane into rat nasal cavity. Tissue Engineering, (ja).
Rausch, C., Zhang, P., Casas-Delucchi, C. S., Daiß, J. L., Engel, C., Coster, G., ... & Cardoso, M. C. (2021). Cytosine base modifications regulate DNA duplex stability and metabolism. Nucleic acids research, 49(22), 12870-12894.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Giacomelli, E., Sala, L., Ward-van Oostwaard, D., & Bellin, M. (2021). Cardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome. Biochemical and Biophysical Research Communications, 572, 118-124.
Devika, A. S., Montebaur, A., Saravanan, S., Bhushan, R., Koch, F., & Sudheer, S. (2021). Human ES Cell Culture Conditions Fail to Preserve the Mouse Epiblast State. Stem cells international, 2021.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Yoshimatsu, S., Murakami, R., Nakajima, M., Sato, T., Kawasaki, H., & Okano, H. (2021). Establishment of an induced pluripotent stem cell line from a female domestic ferret (Mustela putorius furo) with an X chromosome instability. Stem Cell Research, 53, 102385.
Mishra, S., Taelman, J., Chang, Y. W., Boel, A., De Sutter, P., Heindryckx, B., & Chuva De Sousa Lopes, S. M. (2021). Sex-Specific Isolation and Propagation of Human Premeiotic Fetal Germ Cells and Germ Cell-Like Cells. Cells, 10(5), 1214.
Renner, H., Becker, K. J., Kagermeier, T. E., Grabos, M., Eliat, F., Günther, P., ... & Bruder, J. M. (2021). Cell-type-specific high throughput toxicity testing in human midbrain Organoids. Frontiers in molecular neuroscience, 14.
Salti, A., Etemad, S., Cubero, M. S., Albertini, E., Kovacs-Szalka, B., Holzknecht, M., ... & Jansen Dürr, P. (2021). High Glycolytic Activity Enhances Stem Cell Reprogramming of Fahd1-KO Mouse Embryonic Fibroblasts. Cells, 10(8), 2040.
Wang, F., El-Saafin, F., Ye, T., Stierle, M., Negroni, L., Durik, M., ... & Tora, L. (2021). Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription. Cell Death & Differentiation, 1-19.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Stathakos, P., Jiménez-Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., ... & Lane, J. D. (2021). A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. Autophagy, 17(4), 855-871.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Saraswat, D., Shayya, H. J., Polanco, J. J., Tripathi, A., Welliver, R. R., Pol, S. U., ... & Sim, F. J. (2021). Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination. Nature communications, 12(1), 1-18.
Yoshimatsu, S., Qian, E., Sato, T., Yamamoto, M., Ishikawa, M., & Okano, H. (2021). Establishing an induced pluripotent stem cell line from neonatal common marmoset fibroblasts by an all-in-one episomal vector approach. Stem Cell Research, 53, 102380.
Kobayashi, T., Castillo-Venzor, A., Penfold, C. A., Morgan, M., Mizuno, N., Tang, W. W., ... & Surani, M. A. (2021). Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells. Cell Reports, 37(2), 109812.
Breunig, M., Merkle, J., Melzer, M. K., Heller, S., Seufferlein, T., Meier, M., ... & Kleger, A. (2021). Differentiation of human pluripotent stem cells into pancreatic duct-like organoids. STAR protocols, 2(4), 100913.
Tong, Z., Kwak, E., Aguiar, A., Peng, B., Pouton, C. W., Voelcker, N. H., & Haynes, J. M. (2021). Compartmentalized microfluidic chambers enable long-term maintenance and communication between human pluripotent stem cell-derived forebrain and midbrain neurons. Lab on a Chip, 21(20), 4016-4030.
* Purmorphamine + CHIR99021 from Axon Medchem

Yoshida, J., Watanabe, H., Yamauchi, K., Nishikubo, T., Isotani, A., Ohtsuka, S., ... & Horie, K. (2021). Inhibition of N-myristoyltransferase Promotes Naive Pluripotency in Mouse and Human Pluripotent Stem Cells. bioRxiv.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Klima, S., Suciu, I., Hoelting, L., Gutbier, S., Waldmann, T., Dietrich, D. R., & Leist, M. (2021). Examination of microcystin neurotoxicity using central and peripheral human neurons. Alternatives to Animal Experimentation: ALTEX, 38(1), 73-81.
Steinberg, D. J., Repudi, S., Saleem, A., Kustanovich, I., Viukov, S., Abudiab, B., ... & Aqeilan, R. I. (2021). Modeling genetic epileptic encephalopathies using brain organoids. EMBO molecular medicine, 13(8), e13610.
* CHIR99021 + A83-01 + LDN 193189 from Axon Medchem

Zhou, D., Tan, Y., Liu, X., Tang, L., Wang, H., Shen, J., ... & Zhao, M. (2021). Patient-specific iPSC-derived endothelial cells reveal aberrant p38 MAPK signaling in atypical hemolytic uremic syndrome. Stem cell reports, 16(9), 2305-2319.
Campostrini, G., Meraviglia, V., Giacomelli, E., van Helden, R. W., Yiangou, L., Davis, R. P., ... & Mummery, C. L. (2021). Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells. Nature Protocols, 16(4), 2213-2256.
Harberts, J., Siegmund, M., Schnelle, M., Zhang, T., Lei, Y., Yu, L., ... & Blick, R. H. (2021). Robust neuronal differentiation of human iPSC-derived neural progenitor cells cultured on densely-spaced spiky silicon nanowire arrays. Scientific reports, 11(1), 1-10.
Klima, S., Brüll, M., Spreng, A. S., Suciu, I., Falt, T., Schwamborn, J. C., ... & Leist, M. (2021). A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca 2+-signalling. Archives of toxicology, 95(5), 1703-1722.
Buentello, D. C., Koch, L. S., Trujillo-de Santiago, G., Alvarez, M. M., & Broersen, K. (2021). Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies. bioRxiv.
Heller, S., Li, Z., Lin, Q., Geusz, R., Breunig, M., Hohwieler, M., ... & Costa, I. G. (2021). Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation. Communications biology, 4(1), 1-12.
Fabyanic, E. B., Hu, P., Qiu, Q., Wang, T., Berríos, K. N., Flournoy, J., ... & Wu, H. (2021). Quantitative single cell 5hmC sequencing reveals non-canonical gene regulation by non-CG hydroxymethylation. bioRxiv.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Duelen, R., Costamagna, D., Gilbert, G., De Waele, L., Goemans, N., Desloovere, K., ... & Sampaolesi, M. COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv.
Fischer, V., Plassard, D., Ye, T., Reina-San-Martin, B., Stierle, M., Tora, L., & Devys, D. (2021). The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. Cell reports, 36(8), 109598.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Isermann, T., Şener, Ö. Ç., Stender, A., Klemke, L., Winkler, N., Neesse, A., ... & Schulz-Heddergott, R. (2021). Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity. Nature communications, 12(1), 1-17.
Zhu, S., Stanslowsky, N., Fernández-Trillo, J., Mamo, T. M., Yu, P., Kalmbach, N., ... & Viejo-Borbolla, A. (2021). Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2. Stem Cell Research, 56, 102535.
Walter, J., Bolognin, S., Poovathingal, S. K., Magni, S., Gérard, D., Antony, P. M., ... & Schwamborn, J. C. (2021). The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell Reports, 37(3), 109864.
Ghelman, J., Grewing, L., Windener, F., Albrecht, S., Zarbock, A., & Kuhlmann, T. (2021). SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation. bioRxiv.
Wiedenmann, S., Breunig, M., Merkle, J., von Toerne, C., Georgiev, T., Moussus, M., ... & Meier, M. (2021). Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip. Nature biomedical engineering, 5(8), 897-913.
Cao, B., Coelho, S., Li, J., Wang, G., & Pertsinidis, A. (2021). Volumetric interferometric lattice light-sheet imaging. Nature Biotechnology, 39(11), 1385-1393.
Vivas, A., van den Berg, A., Passier, R., Odijk, M., & van der Meer, A. D. (2021). Fluidic Circuit Board with Modular Sensor and Valves Enables Stand-Alone, Tubeless Microfluidic Flow Control in Organs-on-Chips. bioRxiv.
Dolde, X., Karreman, C., Wiechers, M., Schildknecht, S., & Leist, M. (2021). Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays. International journal of molecular sciences, 22(18), 10079.
Duelen, R., Costamagna, D., Gilbert, G., De Waele, L., Goemans, N., Desloovere, K., ... & Sampaolesi, M. (2021). Human iPSC-Based Model Reveals NOX4 as Therapeutic Target in Duchenne Cardiomyopathy. bioRxiv.
Scheer, E., Luo, J., Bernardini, A., Ruffenach, F., Garnier, J. M., Kolb-Cheynel, I., ... & Tora, L. (2021). TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival. Journal of Biological Chemistry, 297(5).
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Funa, N. S., de Lichtenberg, K. H., Hansen, M. S., van Cuyl Kuylenstierna, J., Jensen, K. B., Miao, Y., ... & Serup, P. (2021). TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting multiple endogenous signaling pathways. bioRxiv.
* CHIR99021 and IWP-L6 from Axon Medchem

Desai, V. P., Chouaref, J., Wu, H., Pastor, W. A., Kan, R. L., Oey, H. M., ... & Daxinger, L. (2021). The role of MORC3 in silencing transposable elements in mouse embryonic stem cells. Epigenetics & chromatin, 14(1), 1-14.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Coll, M., Ariño, S., Martínez-Sánchez, C., Garcia-Pras, E., Gallego, J., Moles, A., ... & Sancho-Bru, P. (2021). Ductular reaction promotes intrahepatic angiogenesis through Slit2-Roundabout 1 signaling. Hepatology (Baltimore, Md.).
* CHIR99021, Y 27632, A83-01 and Forskolin from Axon Medchem

Sapir, G., Steinberg, D. J., Aqeilan, R. I., & Katz-Brull, R. (2021). Real-Time Non-Invasive and Direct Determination of Lactate Dehydrogenase Activity in Cerebral Organoids—A New Method to Characterize the Metabolism of Brain Organoids?. Pharmaceuticals, 14(9), 878.
Harberts, J., Bours, K., Siegmund, M., Hedrich, C., Glatza, M., Schöler, H. R., ... & Blick, R. H. (2021). Culturing human iPSC-derived neural progenitor cells on nanowire arrays: mapping the impact of nanowire length and array pitch on proliferation, viability, and membrane deformation. Nanoscale, 13(47), 20052-20066.
Philippi, A., Heller, S., Costa, I. G., Senée, V., Breunig, M., Li, Z., ... & Kleger, A. (2021). Mutations and variants of ONECUT1 in diabetes. Nature Medicine, 27(11), 1928-1940.
萩原玲子. (2021). Generation of metabolically functional hepatocyte-like cells from dedifferentiated fat cells by Foxa2, Hnf4a, and Sall1 transduction.
Jansch, C. (2021). Effects of SLC2A3 copy number variants on neurodevelopment and glucose metabolism in ADHD patient-specific neurons (Doctoral dissertation, Universität Würzburg).
Wiesinger, A., Li, J., Fokkert, L. J., Bakker, P., Verkerk, A. O., Christoffels, V. M., ... & Devalla, H. D. (2021). A single cell transcriptional roadmap for human pacemaker cell differentiation. bioRxiv.
Cano Ballesteros, S. (2021). FSP1/S100A4 delineates distinct cardiac cell populations.
Grandela, C., Blanch-Asensio, A., Brandao, K. O., de Korte, T., Yiangou, L., Mol, M. P., ... & Davis, R. P. (2021). STRAIGHT-IN: A platform for high-throughput targeting of large DNA payloads into human pluripotent stem cells. bioRxiv.
Klein, T. (2021). Establishing an in vitro disease model for Fabry Disease using patient specific induced pluripotent stem cell-derived sensory neurons (Doctoral dissertation, Universität Würzburg).
Festuccia, N., Owens, N., Chervova, A., Dubois, A., & Navarro, P. (2021). The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency. Development, 148(17), dev199604.
Vivas, A., IJspeert, C., Pan, J. Y., Vermeul, K., van den Berg, A., Passier, R., ... & van der Meer, A. D. (2021). Generation and Culture of Cardiac Microtissues in a Microfluidic Chip with a Reversible Open Top Enables Electrical Pacing, Dynamic Drug Dosing and Endothelial Cell Co-Culture. bioRxiv.
van Neerven, S. M., de Groot, N. E., Nijman, L. E., Scicluna, B. P., van Driel, M. S., Lecca, M. C., ... & Vermeulen, L. (2021). Apc-mutant cells act as supercompetitors in intestinal tumour initiation. Nature, 594(7863), 436-441.
Klima, S. (2021). Developmental neurotoxicity in a human model system (Doctoral dissertation).
Reeh, L. (2021). Immunmodulatorische Effekte CD44-positiver Gefäßwand-residenter Stamm-und Vorläuferzellen im myokardialen Gewebe (Doctoral dissertation, Universität Würzburg).
Preciat, G., Moreno, E. L., Wegrzyn, A. B., Willacey, C. C., Modamio, J., Monteiro, F. L., ... & Fleming, R. M. (2021). Mechanistic model-driven exometabolomic characterisation of human dopaminergic neuronal metabolism. bioRxiv.
Shiozawa, S., & Okano, H. Sho Yoshimatsu,* Mayutaka Nakajima, Aozora Iguchi, 4 Tsukasa Sanosaka, Tsukika Sato, Mari Nakamura, Ryusuke Nakajima, 3 Eri Arai, 5 Mitsuru Ishikawa, Kent Imaizumi, Hirotaka Watanabe, Junko Okahara, 3, 6 Toshiaki Noce, 3 Yuta Takeda, 3 Erika Sasaki, 3, 6 Rüdiger Behr, 7, 8 Kazuya Edamura, 4.
Morpurgo, E. NECAB2/MitoNEET represents an alternative activity-triggered mitochondrial quality control system.
Löw, K. (2021). Identifizierung und Charakterisierung koronarer Gefäßwand-residenter Stammzellen (Doctoral dissertation, Universität Würzburg).
Rang, F. J., de Luca, K. L., de Vries, S. S., Valdes-Quezada, C., Boele, E., Nguyen, P. D., ... & Kind, J. (2021). Single-cell profiling of transcriptome and histone modifications with EpiDamID. bioRxiv.
Dolde, X. (2021). Novel neural crest cell function assays to evaluate developmental toxicity hazards (Doctoral dissertation).
Slaats, R. H. MODELLING THE HUMAN HEART.
Dambacher, H. (2021). Die Etablierung des CRISPR/Cas9-Systems in humanen induzierten pluripotenten Stammzellen zur Untersuchung der Funktion des Kanalproteins Connexin 43 in der Embryonalentwicklung (Doctoral dissertation, Universität Würzburg).
持田泰佑. (2021). 消化管と膵臓の内分泌機能に着目した糖尿病および肥満の予防・改善に関する研究 (Doctoral dissertation, 北海道大学).
Zagare, A., Gobin, M., Monzel, A. S., & Schwamborn, J. C. (2021). A robust protocol for the generation of human midbrain organoids. STAR protocols, 2(2), 100524.
Genolet Alberdi, O. (2021). Identification of X-chromosomal genes that drive global X-dosage effects in mammals(Doctoral dissertation).
* 2i: CHIR99021 + PD 0325901 from Axon Medchem
 
Kobayashi, T., Goto, T., Oikawa, M., Sanbo, M., Yoshida, F., Terada, R., ... & Hirabayashi, M. (2021). Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats. Nature communications, 12(1), 1-10.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Gonçalves, C. A., Larsen, M., Jung, S., Stratmann, J., Nakamura, A., Leuschner, M., ... & Grapin-Botton, A. (2021). A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion. Nature communications, 12(1), 1-17.
Schütz, A., Richter, C., Weissgerber, P., Tsvilovskyy, V., Hesse, M., Ottenheijm, R., ... & Freichel, M. (2021). Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos. Cell Reports, 37(3), 109851.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Bruzelius, A., Kidnapillai, S., Drouin-Ouellet, J., Stoker, T., Barker, R. A., & Rylander Ottosson, D. (2021). Reprogramming human adult fibroblasts into GABAergic interneurons. Cells, 10(12), 3450.
* CHIR99021 + PD 0325901 + LDN 193189 from Axon Medchem

Pantier, R., Chhatbar, K., Quante, T., Skourti-Stathaki, K., Cholewa-Waclaw, J., Alston, G., ... & Bird, A. (2021). SALL4 controls cell fate in response to DNA base composition. Molecular cell, 81(4), 845-858.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Zuin, J., Roth, G., Zhan, Y., Cramard, J., Redolfi, J., Piskadlo, E., ... & Giorgetti, L. (2021). Nonlinear control of transcription through enhancer-promoter interactions. bioRxiv.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem
 
Xiong, M., Tao, Y., Gao, Q., Feng, B., Yan, W., Zhou, Y., ... & Zhang, S. C. (2021). Human stem cell-derived neurons repair circuits and restore neural function. Cell Stem Cell, 28(1), 112-126.
Merlevede, A., Legault, E. M., Drugge, V., Barker, R. A., Drouin-Ouellet, J., & Olariu, V. (2021). A quantitative model of cellular decision making in direct neuronal reprogramming. Scientific reports, 11(1), 1-18.
* CHIR99021 + SB 431542 + LDN 193189 from Axon Medchem

Yin, H., Wei, C., & Lee, J. T. (2021). Revisiting the consequences of deleting the X inactivation center. Proceedings of the National Academy of Sciences, 118(25).
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Drouin-Ouellet, J., Pircs, K., Legault, E. M., Birtele, M., Nilsson, F., Shrigley, S., ... & Parmar, M. (2021). Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson's disease. bioRxiv.
* CHIR99021 + SB 431542 + LDN 193189 from Axon Medchem

Saez, M., Blassberg, R., Camacho-Aguilar, E., Siggia, E. D., Rand, D. A., & Briscoe, J. (2021). A quantitative landscape of cell fate transitions identifies principles of cellular decision-making. bioRxiv.
Exelby, K., Herrera-Delgado, E., Perez, L. G., Perez-Carrasco, R., Sagner, A., Metzis, V., ... & Briscoe, J. (2021). Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks. Development, 148(4), dev197566.
Sagner, A., Zhang, I., Watson, T., Lazaro, J., Melchionda, M., & Briscoe, J. (2021). A shared transcriptional code orchestrates temporal patterning of the central nervous system. PLoS biology, 19(11), e3001450.
Lagerwall, J. (2021). Autophagy and antipsychotic treatment response: Characterising a potential relationship in a neuropsychiatric disorders context.
CHIR99021 + SB 431542 + LDN 193189 from Axon Medchem

Bernad, R., Lynch, C. J., Urdinguio, R. G., Stephan-Otto Attolini, C., Fraga, M. F., & Serrano, M. (2021). Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19. Cells, 10(4), 876.
https://www.mdpi.com/2073-4409/10/4/876/htm
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Martinez-Val, A., Lynch, C. J., Calvo, I., Ximénez-Embún, P., Garcia, F., Zarzuela, E., ... & Munoz, J. (2021). Dissection of two routes to naïve pluripotency using different kinase inhibitors. Nature Communications, 12(1), 1-16.
https://www.nature.com/articles/s41467-021-22181-5
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Fischer, V., Plassard, D., Ye, T., San Martin, B. R., Stierle, M., Tora, L., & Devys, D. Two Related Coactivator Complexes SAGA and ATAC Control Embryonic Stem Cell Self-Renewal Through Two Different Acetyltransferase-Independent Mechanisms. Available at SSRN 3782006.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3782006
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Genolet, O., Monaco, A. A., Dunkel, I., Boettcher, M., & Schulz, E. G. (2021). Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach. Genome Biology, 22(1), 1-41.
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-021-02321-2
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Kanagaki, S., Ikeo, S., Suezawa, T., Yamamoto, Y., Seki, M., Hirai, T., ... & Gotoh, S. (2021). Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition. Stem Cells, 39(2), 156-169.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3302

Müller, J. A., Groß, R., Conzelmann, C., Krüger, J., Merle, U., Steinhart, J., ... & Kleger, A. (2021). SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nature Metabolism, 1-17.
https://www.nature.com/articles/s42255-021-00347-1?elqTrackId=e0563488ddb44e0e89d32dfd961b20c6

Nemoto, A., Kobayashi, R., Yoshimatsu, S., Sato, Y., Kondo, T., Yoo, A. S., ... & Okano, H. (2021). Direct Neuronal Reprogramming of Common Marmoset Fibroblasts by ASCL1, microRNA-9/9*, and microRNA-124 Overexpression. Cells, 10(1), 6.
https://www.mdpi.com/2073-4409/10/1/6

Spijkers, X. M., Pasteuning-Vuhman, S., Dorleijn, J. C., Vulto, P., Wevers, N. R., & Pasterkamp, R. J. (2021). A directional 3D neurite outgrowth model for studying motor axon biology and disease. Scientific reports, 11(1), 1-15.
https://www.nature.com/articles/s41598-021-81335-z?elqTrackId=89cdfe62350e4404b93097e862af6ee2

Bartoschek, M. D., Ugur, E., Nguyen, T. A., Rodschinka, G., Wierer, M., Lang, K., & Bultmann, S. (2021). Identification of permissive amber suppression sites for efficient non-canonical amino acid incorporation in mammalian cells. Nucleic Acids Research.
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab132/6158120?login=true
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Qin, W., Stengl, A., Ugur, E., Leidescher, S., Ryan, J., Cardoso, M. C., & Leonhardt, H. (2021). HP1β carries an acidic linker domain and requires H3K9me3 for phase separation. Nucleus, 12(1), 44-57.
https://www.tandfonline.com/doi/full/10.1080/19491034.2021.1889858
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Manstein, F., Ullmann, K., Kropp, C., Halloin, C., Triebert, W., Franke, A., ... & Zweigerdt, R. (2021). High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling. Stem cells translational medicine.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.20-0453
* CHIR99021 and SB 431542 from Axon Medchem

Mishra, S., Taelman, J., Popovic, M., Tilleman, L., Duthoo, E., Van der Jeught, M., ... & Heindryckx, B. (2021). Activin A‐derived human embryonic stem cells show increased competence to differentiate into primordial germ cell‐like cells. Stem Cells.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.3335

Yoshimatsu, M., Ohnishi, H., Zhao, C., Hayashi, Y., Kuwata, F., Okuyama, H., ... & Omori, K. (2021). In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells. Stem cell research, 102233.
https://www.sciencedirect.com/science/article/pii/S1873506121000799

Lee, M. H., Thomas, J. L., Su, Z. L., Yeh, W. K., Monzel, A. S., Bolognin, S., ... & Lin, H. Y. (2021). Epitope imprinting of alpha-synuclein for sensing in Parkinson's brain organoid culture medium. Biosensors and Bioelectronics, 175, 112852.
https://www.sciencedirect.com/science/article/abs/pii/S0956566320308381

Mus, L. M., Van Haver, S., Popovic, M., Trypsteen, W., Lefever, S., Zeltner, N., ... & Speleman, F. (2021). Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions. Genes, Chromosomes and Cancer, 60(4), 272-281.
https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.22931

Zanetti, C., Spitz, S., Berger, E., Bolognin, S., Smits, L., Crepaz, P., ... & Ertl, P. (2021). Monitoring the neurotransmitter release of human midbrain organoids using a redox cycling microsensor as a novel tool for personalized Parkinson’s disease modeling and drug screening. Analyst.
https://pubs.rsc.org/en/content/articlehtml/2021/an/d0an02206c

Chang, W. F., Peng, M., Hsu, J., Xu, J., Cho, H. C., Hsieh-Li, H. M., ... & Sung, L. Y. (2021). Effects of Survival Motor Neuron Protein on Germ Cell Development in Mouse and Human. International Journal of Molecular Sciences, 22(2), 661.
https://www.mdpi.com/1422-0067/22/2/661
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Jansch, C., Ziegler, G. C., Forero, A., Gredy, S., Wäldchen, S., Vitale, M. R., ... & Lesch, K. P. (2021). Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly. Journal of Neural Transmission, 1-17.
https://link.springer.com/article/10.1007/s00702-021-02303-5

Watanabe, M., Yamada, Y., Kurumida, Y., Kameda, T., Sukeno, M., Iizuka-Ohashi, M., ... & Mutoh, M. (2021). Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2. Cancers, 13(5), 982.
https://www.mdpi.com/2072-6694/13/5/982/htm

Wang, F., El-Saafin, F., Ye, T., Stierle, M., Negroni, L., Durik, M., ... & Tora, L. (2021). Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription. bioRxiv.
https://www.biorxiv.org/content/10.1101/2021.02.23.432458v1.abstract
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Fischer, V., Plassard, D., Ye, T., San Martin, B. R., Stierle, M., Tora, L., & Devys, D. Two Related Coactivator Complexes SAGA and ATAC Control Embryonic Stem Cell Self-Renewal Through Two Different Acetyltransferase-Independent Mechanisms. Available at SSRN 3782006.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3782006
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Mira-Bontenbal, H., Tan, B., Gontan, C., Goossens, S., Boers, R. G., Boers, J. B., ... & Gribnau, J. M. (2021). Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells. bioRxiv.
https://www.biorxiv.org/content/10.1101/2021.02.25.432827v1.full

Klein, T. (2021). Establishing an in vitro disease model for Fabry Disease using patient specific induced pluripotent stem cell-derived sensory neurons (Doctoral dissertation, Universität Würzburg).
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/frontdoor/deliver/index/docId/19970/file/Klein_Thomas_iPSC_Dissertation.pdf

Mitsunaga, S., Shioda, K., Hanna, J. H., Isselbacher, K. J., & Shioda, T. (2021). Production and Analysis of Human Primordial Germ Cell–Like Cells. In Testicular Germ Cell Tumors (pp. 125-145). Humana, New York, NY.
https://link.springer.com/protocol/10.1007/978-1-0716-0860-9_10

Kanagaki, S., Suezawa, T., Moriguchi, K., Nakao, K., Toyomoto, M., Yamamoto, Y., ... & Gotoh, S. (2021). Hydroxypropyl cyclodextrin improves amiodarone-induced aberrant lipid homeostasis of alveolar cells. American Journal of Respiratory Cell and Molecular Biology, (ja).
https://onlinelibrary.wiley.com/doi/abs/10.1111/gtc.12736

2020 (105 citations)
Vered, I. (2020). Analysis of translesion DNA synthesis in embryonic stem cells (Doctoral dissertation, The Weizmann Institute of Science).
Analysis of translesion DNA synthesis in embryonic stem cells
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Han, B. Y., Seah, M. K., Brooks, I. R., Quek, D. H., Huxley, D. R., Foo, C. S., ... & Guccione, E. (2020). Global translation during early development depends on the essential transcription factor PRDM10. Nature communications, 11(1), 1-14.
Global translation during early development depends on the essential transcription factor PRDM10
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Ma, H., Hayama, T., Van Dyken, C., Darby, H., Koski, A., Lee, Y., ... & Mitalipov, S. (2020). Deleterious mtDNA mutations are common in mature oocytes. Biology of reproduction, 102(3), 607-619.
https://academic.oup.com/biolreprod/article/102/3/607/5588758?login=true
* 2i: CHIR99021 + PD 0325901 from Axon

Posfai, E., Schell, J. P., Janiszewski, A., Rovic, I., Murray, A., Bradshaw, B., ... & Rossant, J. (2020). Defining totipotency using criteria of increasing stringency. BioRxiv.
https://www.biorxiv.org/content/10.1101/2020.03.02.972893v1.full
* 2i: CHIR99021 + PD 0325901 from Axon

Pacini, G., Dunkel, I., Mages, N., Mutzel, V., Timmermann, B., Marsico, A., & Schulz, E. G. (2020). Integrated analysis of Xist upregulation and gene silencing at the onset of random X-chromosome inactivation at high temporal and allelic resolution. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.07.20.211573v1.full
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Lynch, C. J., Bernad, R., Martínez-Val, A., Shahbazi, M. N., Nóbrega-Pereira, S., Calvo, I., ... & Serrano, M. (2020). Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nature Cell Biology, 22(10), 1223-1238.
https://www.nature.com/articles/s41556-020-0573-1. 
* CHIR99021, PD 0325901 and BIRB 796 from Axon Medchem

Kong, J. H., Young, C. B., Pusapati, G. V., Patel, C. B., Ho, S., Krishnan, A., ... & Rohatgi, R. (2020). A membrane-tethered ubiquitination pathway regulates Hedgehog signaling and heart development. Developmental Cell, 55(4), 432-449.
* CHIR99021 and PD 98059 from Axon Medchem

Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., ... & Ohteki, T. (2020). Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nature Cell Biology, 22(8), 919-926.

Neagu, A., van Genderen, E., Escudero, I., Verwegen, L., Kurek, D., Lehmann, J., ... & Ten Berge, D. (2020). In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states. Nature cell biology, 22(5), 534-545.
https://www.nature.com/articles/s41556-020-0508-x

Ma, B., Trieu, T. J., Habib, S. J., & Chen, X. (2020). Protocol for Establishing Mouse Embryonic Stem Cells to Study Histone Inheritance Pattern at Single-Cell Resolution. STAR protocols, 1(3), 100178.
https://www.sciencedirect.com/science/article/pii/S2666166720301659
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Castel, G., Meistermann, D., Bretin, B., Firmin, J., Blin, J., Loubersac, S., ... & David, L. (2020). Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells. Cell Reports, 33(8), 108419.
https://www.sciencedirect.com/science/article/pii/S221112472031408X
* 8 inhibitors are from Axon Medchem, including CHIR99021, PD 0325901, Y 27632, IWR-1, A83-01, SB4 31542, Go 6983, Forskolin.

Dries, R., Stryjewska, A., Coddens, K., Okawa, S., Notelaers, T., Birkhoff, J., ... & Huylebroeck, D. (2020). Integrative and perturbation‐based analysis of the transcriptional dynamics of TGFβ/BMP system components in transition from embryonic stem cells to neural progenitors. Stem Cells, 38(2), 202-217.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.3111
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Kuo, Y. C., Hsu, C. C., & Rajesh, R. (2020). iPSCs-laden GDF8-grafted aldehyde hyaluronic acid-polyacrylamide inverted colloidal crystal constructs with controlled release of CHIR99021 and retinoic acid to generate insulin-producing cells. Journal of the Taiwan Institute of Chemical Engineers, 116, 223-237.
https://www.sciencedirect.com/science/article/pii/S1876107020303412

Shiozawa, S., Nakajima, M., Okahara, J., Kuortaki, Y., Kisa, F., Yoshimatsu, S., ... & Okano, H. (2020). Primed to naïve-like conversion of the common marmoset embryonic stem cells. Stem cells and development, 29(12), 761-773.
https://www.liebertpub.com/doi/abs/10.1089/scd.2019.0259

Sangokoya, C., & Blelloch, R. (2020). MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis. Proceedings of the National Academy of Sciences, 117(34), 20625-20635.
https://www.pnas.org/content/117/34/20625.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Stathakos, P., Jiménez-Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., ... & Lane, J. D. (2020). A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. Autophagy, 1-17.
https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1739441
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Postlmayr, A., Dumeau, C. E., & Wutz, A. (2020). Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. Development, 147(11).
https://dev.biologists.org/content/147/11/dev175141.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Lee, M. H., Thomas, J. L., Su, Z. L., Yeh, W. K., Monzel, A. S., Bolognin, S., ... & Lin, H. Y. (2020). Epitope imprinting of alpha-synuclein for sensing in Parkinson's brain organoid culture medium. Biosensors and Bioelectronics, 112852.
https://www.sciencedirect.com/science/article/abs/pii/S0956566320308381

Qiu, Q., Hu, P., Qiu, X., Govek, K. W., Cámara, P. G., & Wu, H. (2020). Massively parallel and time-resolved RNA sequencing in single cells with scNT-seq. Nature methods, 17(10), 991-1001.
https://www.nature.com/articles/s41592-020-0935-4
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Schruf, E., Schroeder, V., Le, H. Q., Schönberger, T., Raedel, D., Stewart, E. L., ... & Garnett, J. P. (2020). Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in a human iPSC‐derived air‐liquid interface model. The FASEB Journal, 34(6), 7825-7846.
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.201902926R

Castel, G., Meistermann, D., Bretin, B., Firmin, J., Justine, B. L. I. N., Loubersac, S., ... & David, L. (2020). Generation of human induced trophoblast stem cells. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.09.15.298257v1.full
* 5i: CHIR99021, PD0325901, Y27632, PD173074 from Axon Medchem

Yoshimatsu, M., Ohnishi, H., Zhao, C., Hayashi, Y., Kuwata, F., Kaba, S., ... & Omori, K. In Vivo Regeneration of Rat Laryngeal Cartilage with Mesenchymal Stem Cells Derived from Human Induced Pluripotent Stem Cells Via Neural Crest Cells. Available at SSRN 3733569.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3733569

Luo, X., van der Veer, B. K., Sun, L., Bartoccetti, M., Boretto, M., Vankelecom, H., ... & Koh, K. P. (2020). Coordination of germ layer lineage choice by TET1 during primed pluripotency. Genes & development, 34(7-8), 598-618.
http://genesdev.cshlp.org/content/34/7-8/598.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Giacomelli, E., Meraviglia, V., Campostrini, G., Cochrane, A., Cao, X., van Helden, R. W., ... & Mummery, C. L. (2020). Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease. Cell Stem Cell, 26(6), 862-879.
https://www.sciencedirect.com/science/article/pii/S1934590920302022

Yamanaka, Y., Uemura, M., & Alev, C. (2020). Stepwise in vitro induction of human somitic mesoderm and its derivatives.
https://www.researchsquare.com/article/pex-827/v1.pdf

Harberts, J., Kusch, M., O’Sullivan, J., Zierold, R., & Blick, R. H. (2020). A Temperature-Controlled Patch Clamp Platform Demonstrated on Jurkat T Lymphocytes and Human Induced Pluripotent Stem Cell-Derived Neurons. Bioengineering, 7(2), 46.
https://www.mdpi.com/2306-5354/7/2/46

Hagiwara, R., Oki, Y., Matsumaru, T., Ibayashi, S., & Kano, K. (2020). Generation of metabolically functional hepatocyte‐like cells from dedifferentiated fat cells by Foxa2, Hnf4a and Sall1 transduction. Genes to Cells, 25(12), 811-824.
https://onlinelibrary.wiley.com/doi/abs/10.1111/gtc.12814

Ribeiro, M. C., Slaats, R. H., Schwach, V., Rivera-Arbelaez, J. M., Tertoolen, L. G., Van Meer, B. J., ... & Passier, R. (2020). A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness. Journal of molecular and cellular cardiology, 141, 54-64.
https://www.sciencedirect.com/science/article/pii/S0022282820300699

Yamamoto, Y., Korogi, Y., Hirai, T., & Gotoh, S. (2020). A method of generating alveolar organoids using human pluripotent stem cells. In Methods in Cell Biology (Vol. 159, pp. 115-141). Academic Press.
https://www.sciencedirect.com/science/article/pii/S0091679X20300108

Bayerl, J., Ayyash, M., Shani, T., Manor, Y., Gafni, O., Kalma, Y., ... & Hanna, J. H. (2020). Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.05.23.112433v1.full
* CHIR99021, PD 0325901, IWR-1, XAV 939, BIRB0796, Go6983, Y27632, CGP77675, LDN193189, A83-01, DBZ, SB590885, BIX02189, RU-SKI43, BIX-02194

Bollmanna, E., Schreibera, J. A., Rittera, N., Peischarda, S., Hoa, H. T., Wünschb, B., ... & Seebohma, G. (2020). Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region. Cell Physiol Biochem, 54, 321-332.
https://www.researchgate.net/profile/Julian_Schreiber/publication/340512366_44'-Diisothiocyanato-22'-Stilbenedisulfonic_Acid_DIDS_Modulates_the_Activity_of_KCNQ1KCNE1_Channels_by_an_Interaction_with_the_Central_Pore_Region/links/5ea126da458515ec3aff263c/4-4-Diisothiocyanato-2-2-Stilbenedisulfonic-Acid-DIDS-Modulates-the-Activity-of-KCNQ1-KCNE1-Channels-by-an-Interaction-with-the-Central-Pore-Region.pdf

Kane, K. I., Jarazo, J., Moreno, E. L., Fleming, R. M., & Schwamborn, J. C. (2020). Passive controlled flow for Parkinson's disease neuronal cell culture in 3D microfluidic devices. Organs-on-a-Chip, 2, 100005.
https://www.sciencedirect.com/science/article/pii/S2666102020300057

Salzberg, Y., Pechuk, V., Gat, A., Setty, H., Sela, S., & Oren-Suissa, M. (2020). Synaptic protein degradation controls sexually dimorphic circuits through regulation of DCC/UNC-40. Current Biology, 30(21), 4128-4141.
https://www.sciencedirect.com/science/article/pii/S0960982220311568

Bustos, F., Segarra-Fas, A., Nardocci, G., Cassidy, A., Antico, O., Davidson, L., ... & Findlay, G. M. (2020). Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling. Developmental cell, 55(5), 629-647.
https://www.sciencedirect.com/science/article/pii/S1534580720307577
* CHIR99021, PD0325901 and SPHINX31 from Axon Medchem

Steinberg, D. J., Saleem, A., Repudi, S. R., Banne, E., Mahajnah, M., Hanna, J. H., ... & Aqeilan, R. I. (2020). Modeling Genetic Epileptic Encephalopathies using Brain Organoids. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.08.23.263236v1.full
* CHIR99021, LDN193189, A83-01 from Axon Medchem

Vila-Cejudo, M., Alonso-Alonso, S., Pujol, A., Santaló, J., & Ibáñez, E. (2020). Wnt pathway modulation generates blastomere-derived mouse embryonic stem cells with different pluripotency features. Journal of Assisted Reproduction and Genetics, 37(12), 2967-2979.
https://link.springer.com/article/10.1007/s10815-020-01964-7
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Alendar, A., Lambooij, J. P., Bhaskaran, R., Lancini, C., Song, J. Y., van Vugt, H., ... & Berns, A. (2020). Gene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development. PloS one, 15(5), e0233394.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233394
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Weinberger, L. (2020). Characterization of human naive pluripotent stem cells and their differentiation to Primordial Germ Cells (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1274955990003596/1374919490003596
* CHIR99021, PD0325901, SB202190, BIRB796, Y27632, CGP77675 from Axon Medchem

Ma, B., Trieu, T. J., Cheng, J., Zhou, S., Tang, Q., Xie, J., ... & Chen, X. (2020). Differential histone distribution patterns in induced asymmetrically dividing mouse embryonic stem cells. Cell Reports, 32(6), 108003.
https://www.sciencedirect.com/science/article/pii/S2211124720309888
*2i: CHIR99021 and PD0325901 from Axon Medchem

Klima, S., Suciu, I., Hoelting, L., Gutbier, S., Waldmann, T., Dietrich, D. R., & Leist, M. (2020). Examination of microcystin neurotoxicity using central and peripheral human neurons. Alternatives to Animal Experimentation: ALTEX.
http://kops.uni-konstanz.de/handle/123456789/50031

Schenke, M., Schjeide, B. M., Püschel, G. P., & Seeger, B. (2020). Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays. Toxins, 12(5), 276.
https://www.mdpi.com/2072-6651/12/5/276/htm

Nesterenko, Y., Dolde, X., Leist, M., & Mayans, O. (2020). Strategy to replace animal-derived ECM by a modular and highly defined matrix. Alternatives to Animal Experimentation: ALTEX, 37(3).
http://kops.uni-konstanz.de/handle/123456789/49891

Heß, K., Starost, L., Kieran, N. W., Thomas, C., Vincenten, M. C., Antel, J., ... & Kuhlmann, T. (2020). Lesion stage-dependent causes for impaired remyelination in MS. Acta neuropathologica, 140(3), 359-375.
https://link.springer.com/article/10.1007/s00401-020-02189-9

Kamiya, D., Takenaka-Ninagawa, N., Motoike, S., Kajiya, M., Akaboshi, T., Zhao, C., ... & Ikeya, M. Induction of Functional Mesenchymal Stem/Stromal Cells from Human iPCs Via a Neural Crest Cell Lineage Under Xeno-Free Conditions. Stromal Cells from Human iPCs Via a Neural Crest Cell Lineage Under Xeno-Free Conditions.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3741231

Minamide, K., Sato, T., Nakanishi, Y., Ohno, H., Kato, T., Asano, J., & Ohteki, T. (2020). IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. Scientific reports, 10(1), 1-12.
https://www.nature.com/articles/s41598-020-71633-3?elqTrackId=5f68eaf2a3044295b9a1caad4716bf51

Lasman, L., Krupalnik, V., Viukov, S., Mor, N., Aguilera-Castrejon, A., Schneir, D., ... & Hanna, J. H. (2020). Context-dependent functional compensation between Ythdf m6A reader proteins. Genes & development, 34(19-20), 1373-1391.
https://www.biorxiv.org/content/biorxiv/early/2020/06/03/2020.06.03.131441.full.pdf
* 2i from Axon Medchem

Kano, M., Takanashi, M., Oyama, G., Yoritaka, A., Hatano, T., Shiba-Fukushima, K., ... & Hattori, N. (2020). Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations. npj Parkinson's Disease, 6(1), 1-9.
https://www.nature.com/articles/s41531-020-00137-8

Starost, L., Lindner, M., Herold, M., Xu, Y. K. T., Drexler, H. C., Heß, K., ... & Kuhlmann, T. (2020). Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis. Acta neuropathologica, 140(5), 715-736.
https://link.springer.com/article/10.1007/s00401-020-02217-8

Gafni, O. (2020). Delineating routes and applications of naive pluripotency (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1275016610003596/1375015210003596
* CHIR99021, PD0325901, SB201920, Y27632, BIRB796 from Axon Medchem

Mulholland, C. B., Traube, F. R., Ugur, E., Parsa, E., Eckl, E. M., Schönung, M., ... & Bultmann, S. (2020). Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency. Scientific reports, 10(1), 1-12.
https://www.nature.com/articles/s41598-020-68600-3?elqTrackId=f22b504ca3bf400ca13ed38bda449fd7
* 2i from Axon Medchem

Liu, Y., Bai, H., Guo, F., Thai, P. N., Luo, X., Zhang, P., ... & Lu, X. (2020). PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells. Aging (Albany NY), 12(8), 7411.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202542/

Fischer, V., Plassard, D., Ye, T., San Martin, B. R., Stierle, M., Tora, L., & Devys, D. Two Related Coactivator Complexes SAGA and ATAC Control Embryonic Stem Cell Self-Renewal Through Two Different Acetyltransferase-Independent Mechanisms. Available at SSRN 3782006.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3782006
* 2i from Axon Medchem

Geula, S. (2020). Deciphering the molecular role of N6-Methyladenosine mRNA modification in development of mammalian stem cells (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1274920170003596/1374919530003596

Nickels, S. L., Modamio, J., Mendes-Pinheiro, B., Monzel, A. S., Betsou, F., & Schwamborn, J. C. (2020). Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease. Stem Cell Research, 46, 101870.
https://www.sciencedirect.com/science/article/pii/S1873506120301719

Allijn, I., Ribeiro, M., Poot, A., Passier, R., & Stamatialis, D. (2020). Membranes for modelling cardiac tissue stiffness in vitro based on poly (Trimethylene carbonate) and poly (ethylene glycol) polymers. Membranes, 10(10), 274.
https://www.mdpi.com/2077-0375/10/10/274

Ignatova, V. V., Stolz, P., Kaiser, S., Gustafsson, T. H., Lastres, P. R., Sanz-Moreno, A., ... & Schneider, R. (2020). The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes & development, 34(9-10), 715-729.
http://genesdev.cshlp.org/content/34/9-10/715.full
* 2i from Axon Medchem

Breuls, N., Giarratana, N., Yedigaryan, L., Carai, P., Heymans, S., Ranga, A., ... & Sampaolesi, M. (2020). Valproic acid stimulates myogenesis in pluripotent stem cell–derived mesodermal progenitors in a Notch-dependent manner. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.12.16.423053v1.full

Schruf, E. (2020). Recapitulating aspects of alveolar epithelial dysfunction related to idiopathic pulmonary fibrosis utilizing an iPSC-derived air-liquid interface model system (Doctoral dissertation, Universität Ulm).
https://oparu.uni-ulm.de/xmlui/handle/123456789/33478

Shetzer, Y. (2020). Losing the brakes: p53 loss of heterozygosity in malignant transformation of differentiated cells and stem cells (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1275000770003596/1375014450003596

Panagiotakopoulou, V., Ivanyuk, D., De Cicco, S., Haq, W., Arsić, A., Yu, C., ... & Deleidi, M. (2020). Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells. Nature communications, 11(1), 1-17.
https://www.nature.com/articles/s41467-020-18755-4

van IJzendoorn, D. G., Salvatori, D. C., Cao, X., van den Hil, F., Briaire-de Bruijn, I. H., de Jong, D., ... & Orlova, V. V. (2020). Vascular Tumor Recapitulated in Endothelial Cells from hiPSCs Engineered to Express the SERPINE1-FOSB Translocation. Cell Reports Medicine, 1(9), 100153.
https://www.sciencedirect.com/science/article/pii/S2666379120302007

Spada, F., Schiffers, S., Kirchner, A., Zhang, Y., Arista, G., Kosmatchev, O., ... & Carell, T. (2020). Active turnover of genomic methylcytosine in pluripotent cells. Nature Chemical Biology, 16(12), 1411-1419.
https://www.nature.com/articles/s41589-020-0621-y
* from Axon Medchem (CHIR, CGP, PD, IWR1)
Krupalnik, V. (2020). Aire as a novel factor promoting induction of pluripotency (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1275016260003596/1375015250003596
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., ... & Ohteki, T. (2020). Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine. Scientific reports, 10(1), 1-15.
https://www.nature.com/articles/s41598-020-64987-1

Lange, L., Hoffmann, D., Schwarzer, A., Ha, T. C., Philipp, F., Lenz, D., ... & Schambach, A. (2020). Inducible forward programming of human pluripotent stem cells to hemato-endothelial progenitor cells with hematopoietic progenitor potential. Stem cell reports, 14(1), 122-137.
https://www.sciencedirect.com/science/article/pii/S2213671119304084

Ignatova, V. V., Kaiser, S., Ho, J. S. Y., Bing, X., Stolz, P., Tan, Y. X., ... & Schneider, R. (2020). METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth. Science advances, 6(35), eaaz4551.
https://advances.sciencemag.org/content/6/35/eaaz4551.abstract

Ohishi, H., Au Yeung, W. K., Unoki, M., Ichiyanagi, K., Fukuda, K., Maenohara, S., ... & Sasaki, H. (2020). Characterization of genetic‐origin‐dependent monoallelic expression in mouse embryonic stem cells. Genes to Cells, 25(1), 54-64.
https://onlinelibrary.wiley.com/doi/abs/10.1111/gtc.12736

Rausch, C., Weber, P., Prorok, P., Hörl, D., Maiser, A., Lehmkuhl, A., ... & Cardoso, M. C. (2020). Developmental differences in genome replication program and origin activation. Nucleic acids research, 48(22), 12751-12777.
https://academic.oup.com/nar/article/48/22/12751/6017362?login=true
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Smits, L. M., Magni, S., Kinugawa, K., Grzyb, K., Luginbühl, J., Sabate-Soler, S., ... & Schwamborn, J. C. (2020). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Cell and tissue research, 382(3), 463-476.
https://link.springer.com/article/10.1007/s00441-020-03249-y

Varga, J., Nicolas, A., Petrocelli, V., Pesic, M., Mahmoud, A., Michels, B. E., ... & Greten, F. R. (2020). AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer. Journal of Experimental Medicine, 217(10).
https://rupress.org/jem/article-abstract/217/10/e20191515/151998

Di Minin, G., Dumeau, C. E., Grison, A., Chan, W., Monfort, A., Jerome-Majewska, L. A., & Wutz, A. (2020). Tmed2 regulates Smoothened trafficking and Hedgehog signalling. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.04.20.049957v1.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Mulholland, C. B., Nishiyama, A., Ryan, J., Nakamura, R., Yiğit, M., Glück, I. M., ... & Leonhardt, H. (2020). Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nature communications, 11(1), 1-24.
https://www.nature.com/articles/s41467-020-19603-1
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Schenke, M. (2020). DOCTOR OF PHILOSOPHY (PhD) (Doctoral dissertation, University of Veterinary Medicine Hannover).
https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00000305/SchenkeM-ss20%20.pdf

Renner, H., Grabos, M., Becker, K. J., Kagermeier, T. E., Wu, J., Otto, M., ... & Bruder, J. M. (2020). A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids. Elife, 9, e52904.
https://elifesciences.org/articles/52904

Butti, E., Cattaneo, S., Bacigaluppi, M., Cambiaghi, M., Scotti, G., Brambilla, E., ... & Martino, G. (2020). Neural precursor cells contribute to decision-making by tuning striatal connectivity via secretion of IGFBPL-1. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.12.29.424678v1.full

Rais, Y. (2020). Deterministic reprogramming of somatic cells to pluripotency via regulation of Mbd3/NuRD activity (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1275015690003596/1375014170003596

Pieters, T., Sanders, E., Tian, H., van Hengel, J., & Van Roy, F. (2020). Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice. BMC developmental biology, 20(1), 1-18.
https://link.springer.com/article/10.1186/s12861-020-00222-4
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Rao, V. K., Swarnaseetha, A., Tham, G. H., Lin, W. Q., Han, B. B., Benoukraf, T., ... & Ong, C. T. (2020). Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation. Nucleic acids research, 48(3), 1225-1238.
https://academic.oup.com/nar/article/48/3/1225/5661090?login=true

Warzych, E., Pawlak, P., Lechniak, D., & Madeja, Z. E. (2020). WNT signalling supported by MEK/ERK inhibition is essential to maintain pluripotency in bovine preimplantation embryo. Developmental biology, 463(1), 63-76.
https://www.sciencedirect.com/science/article/pii/S001216062030124X
* many inhibitors used were from Axon Medchem

Moretti, A., Fonteyne, L., Giesert, F., Hoppmann, P., Meier, A. B., Bozoglu, T., ... & Kupatt, C. (2020). Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy. Nature medicine, 26(2), 207-214.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212064/

Liu, Z., Tardat, M., Gill, M. E., Royo, H., Thierry, R., Ozonov, E. A., & Peters, A. H. (2020). SUMO ylated PRC 1 controls histone H3. 3 deposition and genome integrity of embryonic heterochromatin. The EMBO journal, 39(13), e103697.
https://www.embopress.org/doi/full/10.15252/embj.2019103697
(3 μM CHIR99021 and 0.8 μM PD184352, Axon Medchem).

Fischer, B. (2020). Comparative analysis of biopolymer-based scaffolds for therapeutically relevant cells.
https://scidok.sulb.uni-saarland.de/handle/20.500.11880/30668
https://scidok.sulb.uni-saarland.de/bitstream/20.500.11880/30668/1/Dissertation_Benjamin_Fischer.pdf

Evans, R. E. (2020). Biomaterial encapsulation to improve cell therapy for Parkinson's disease (Doctoral dissertation, UCL (University College London)).

Kane, K. I., Jarazo, J., Moreno, E. L., Fleming, R. M., & Schwamborn, J. C. (2020). Passive controlled flow for Parkinson's disease neuronal cell culture in 3D microfluidic devices. Organs-on-a-Chip, 2, 100005.

Ito, H., Watari, K., Shibata, T., Miyamoto, T., Murakami, Y., Nakahara, Y., ... & Ono, M. (2020). Bidirectional regulation between NDRG1 and GSK3β controls tumor growth and is targeted by differentiation inducing factor-1 in glioblastoma. Cancer research, 80(2), 234-248.
https://cancerres.aacrjournals.org/content/80/2/234.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Genolet, O., Monaco, A. A., Dunkel, I., Boettcher, M., & Schulz, E. G. (2020). Identification of X-chromosomal genes that drive global X-dosage effects in mammals. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.03.09.983544v1.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Cuartas-López, A. M., & Gallego-Gómez, J. C. (2020). Glycogen synthase kinase 3ß participates in late stages of Dengue virus-2 infection. Memórias do Instituto Oswaldo Cruz, 115.

Nishiyama, A., Mulholland, C. B., Bultmann, S., Kori, S., Endo, A., Saeki, Y., ... & Kumamoto, S. (2020). Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nature Communications, 11(1), 1-17.
https://www.nature.com/articles/s41467-020-15006-4
2i: PD0325901 and CHIR99021 from Axon Medchem

Katsuda, T., Kawamata, M., Inoue, A., Yamaguchi, T., Abe, M., & Ochiya, T. (2020). Long‐term maintenance of functional primary human hepatocytes using small molecules. FEBS letters, 594(1), 114-125.
https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13582
2i: CHIR99021 and PD0325901 from Axon Medchem

Rao, V. K., Swarnaseetha, A., Tham, G. H., Lin, W. Q., Han, B. B., Benoukraf, T., ... & Ong, C. T. (2020). Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation. Nucleic Acids Research, 48(3), 1225-1238.
https://academic.oup.com/nar/article/48/3/1225/5661090

Mochida, T., Ueno, H., Tsubooka-Yamazoe, N., Hiyoshi, H., Ito, R., Matsumoto, H., & Toyoda, T. (2020). Insulin-Deficient Diabetic Condition Upregulates the Insulin-Secreting Capacity of Human Induced Pluripotent Stem Cell–Derived Pancreatic Endocrine Progenitor Cells After Implantation in Mice. Diabetes, 69(4), 634-646.
https://diabetes.diabetesjournals.org/content/69/4/634.abstract

Bérenger-Currias, N. M., Mircea, M., Adegeest, E., van den Berg, P. R., Feliksik, M., Hochane, M., ... & Semrau, S. (2020). Early neurulation recapitulated in assemblies of embryonic and extraembryonic cells. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.02.13.947655v1.abstract

Rahimoff, R., & KSR, K. S. R. (2020). 4 Material und Methoden der unveröffentlichten Arbeiten. Untersuchung des Metabolismus nicht-kanonischer DNA-Basen in embryonalen Stammzellen, 121.
https://edoc.ub.uni-muenchen.de/25568/1/Kirchner_Angie_G.pdf#page=137
*3i: PD0325901, CHIR99021, and CGP77675 from Axon Medchem

El-Sehemy, A., Selvadurai, H. J., Ortin-Martinez, A., Pokrajac, N. T., Mamatjan, Y., Tachibana, N., ... & Dirks, P. (2020). Norrin mediates tumor-promoting and-suppressive effects in glioblastoma via Notch and WNT. The Journal of Clinical Investigation. 130(6):3069-3086.
https://www.jci.org/articles/view/128994/pdf

Meek, S., Wei, J., Oh, T., Watson, T., Olavarrieta, J., Sutherland, L., ... & Burdon, T. (2020). A Stem Cell Reporter for Investigating Pluripotency and Self-Renewal in the Rat. Stem Cell Reports. 14 (1), 154-166.
https://www.sciencedirect.com/science/article/pii/S2213671119304151

Tang, L., Wang, H., Dai, B., Wang, X., Zhou, D., Shen, J., ... & Wu, Q. (2020). Human induced pluripotent stem cell-derived cardiomyocytes reveal abnormal TGFβ signaling in type 2 diabetes mellitus. Journal of Molecular and Cellular Cardiology. 142, 53-64.
https://www.sciencedirect.com/science/article/pii/S002228282030081X

Shiozawa, S., Nakajima, M., Okahara, J., Kuortaki, Y., Kisa, F., Yoshimatsu, S., ... & Nikaido, I. (2020). Primed to naïve-like conversion of the common marmoset embryonic stem cells. Stem Cells and Development, 29, 12, https://doi.org/10.1089/scd.2019.0259
https://www.liebertpub.com/doi/abs/10.1089/scd.2019.0259

Haraguchi, S., Dang-Nguyen, T. Q., Wells, D., Fuchimoto, D., Fukuda, T., & Tokunaga, T. (2020). Establishment of porcine nuclear transfer-derived embryonic stem cells using induced pluripotent stem cells as donor nuclei. Journal of Reproduction and Development, 2019-137.
https://www.jstage.jst.go.jp/article/jrd/advpub/0/advpub_2019-137/_article/-char/ja/

Bartoccetti, M., van der Veer, B. K., Luo, X., Khoueiry, R., She, P., Bajaj, M., ... & Koh, K. P. (2020). Regulatory dynamics of Tet1 and Oct4 resolve stages of global DNA demethylation and transcriptomic changes in reprogramming. Cell reports, 30(7), 2150-2169.
https://www.sciencedirect.com/science/article/pii/S2211124720300905
*2i: CHIR99021 and PD0325901 from Axon Medchem

Saraswat, D., Polanco, J. J., Shayya, H. J., Tripathi, A., Welliver, R., Pol, S. U., ... & Dutta, R. (2020). Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelination. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.01.21.906073v2.abstract

Van Den Brink, L., Brandão, K. O., Yiangou, L., Mol, M. P., Grandela, C., Mummery, C. L., ... & Davis, R. P. (2020). Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties. Stem Cell Research, 43, 101698.
https://www.sciencedirect.com/science/article/pii/S1873506119303289

De Cicco, S., Ivanyuk, D., Haq, W., Panagiotakopoulou, V., Arsic, A., Schoendorf, D., ... & Schneiderhan-Marra, N. (2020). Interferon-γ signaling synergizes with LRRK2 in human neurons and microglia. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.01.30.925222v1.abstract

Le Harzic, R., Meiser, I., Neubauer, J. C., Riemann, I., Schiffer, M., Stracke, F., & Zimmermann, H. (2020). Diffraction-based technology for the monitoring of contraction dynamics in 3D and 2D tissue models. Biomedical Optics Express, 11(2), 517-532.
https://www.osapublishing.org/abstract.cfm?uri=boe-11-2-517

Marques, L. B., Ottoni, F. M., Pinto, M. C. X., Ribeiro, J. M., de Sousa, F. S., Weinlich, R., ... & Alves, R. J. (2020). Lapachol acetylglycosylation enhances its cytotoxic and pro-apoptotic activities in HL60 cells. Toxicology in Vitro, 65, 104772.
https://www.sciencedirect.com/science/article/pii/S0887233319307131

Katsuda, T., Hosaka, K., Matsuzaki, J., Usuba, W., Prieto-Vila, M., Yamaguchi, T., ... & Ochiya, T. (2020). Transcriptomic dissection of hepatocyte heterogeneity: linking ploidy, zonation, and stem/progenitor cell characteristics. Cellular and molecular gastroenterology and hepatology, 9(1), 161-183.
https://www.sciencedirect.com/science/article/pii/S2352345X19301171

2019 (74 citations)
Karoutas, A., Szymanski, W., Rausch, T., Guhathakurta, S., Rog-Zielinska, E. A., Peyronnet, R., ... & Kimura, H. (2019). The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nature Cell Biology, 21(10), 1248-1260.  
https://www.nature.com/articles/s41556-019-0397-z
*2i: CHIR99021 + PD0325901 from Axon Medchem

Hamilton, W. B., Mosesson, Y., Monteiro, R. S., Emdal, K. B., Knudsen, T. E., Francavilla, C., ... & Brickman, J. M. (2019). Dynamic lineage priming is driven via direct enhancer regulation by ERK. Nature, 575(7782), 355-360.
https://www.nature.com/articles/s41586-019-1732-z

Madeja, Z. E., Warzych, E., Pawlak, P., & Lechniak, D. (2019). Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications, 510(3), 403-408.
https://www.sciencedirect.com/science/article/abs/pii/S0006291X19301421
*CHIR99021, PD0325901, PD184352 and SU5402 from Axon Medchem

M A Garcia-Campos, S Edelheit, U Toth, M Safra, R Shachar, S Viukov, R Winkler, R tNir, L Lasman, A Brandis, J H.Hanna, W Rossmanith, S Schwartz. Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling. Cell, 2019, 178 (3), 731-747.
https://www.sciencedirect.com/science/article/pii/S0092867419306762
*2i: CHIR99021 and PD0325901 from Axon medchem.

Giulitti, S., Pellegrini, M., Zorzan, I., Martini, P., Gagliano, O., Mutarelli, M., ... & Martello, G. (2019). Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nat. Cell Biol, 21, 1-19.
https://www.nature.com/articles/s41556-018-0254-5.pdf?origin=ppub
*6i: CHIR99021, PD0325901, GO6983, WH-4-023, SB590885, and Y27632 from Axon Medchem

Heurtier, V., Owens, N., Gonzalez, I., Mueller, F., Proux, C., Mornico, D., ... & Navarro, P. (2019). The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells. Nature communications, 10(1), 1109.
https://www.nature.com/articles/s41467-019-09041-z
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Kamenova, I., Mukherjee, P., Conic, S., Mueller, F., El-Saafin, F., Bardot, P., ... & Vincent, S. D. (2019). Co-translational assembly of mammalian nuclear multisubunit complexes. Nature communications, 10(1), 1-15.
https://www.nature.com/articles/s41467-019-09749-y
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Rooijers, K., Markodimitraki, C. M., Rang, F. J., de Vries, S. S., Chialastri, A., de Luca, K. L., ...  Dey, S. & Kind, J. (2019). Simultaneous quantification of protein–DNA contacts and transcriptomes in single cells. Nature biotechnology, 37(7), 766-772.
https://www.nature.com/articles/s41587-019-0150-y
*2i: CHIR99021 and PD0325901 from Axon Medchem

Rooijers, K., Markodimitraki, C. M., Rang, F. J., de Vries, S. S., Chialastri, A., de Luca, K. L., ... & Kind, J. (2019). scDam&T‐seq combines DNA adenine methyltransferase-based labeling of protein-DNA contact sites with transcriptome sequencing to analyze regulatory programs in single cells. Nature biotechnology, 37(7), 766.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609448/
*2i: CHIR99021 and PD0325901 from Axon Medchem

Li, J., Rozwadowska, N., Clark, A., Fil, D., Napierala, J. S., & Napierala, M. (2019). Excision of the expanded GAA repeats corrects cardiomyopathy phenotypes of iPSC-derived Friedreich's ataxia cardiomyocytes. Stem cell research, 40, 101529.
https://www.sciencedirect.com/science/article/pii/S187350611930159X

B. Di Stefano, E.C. Luo, C. Haggerty, ..., A. Meissner, Gene W. Yeo, K. Hochedlinger (2019) The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. Cell Stem Cell, 25, 1-17.
http://yeolab.github.io/papers/2019/Stefano_Enching_cellstemmcell_2019.pdf
* IM-12, SB590885, WH-4-23, PD0325901, CHIR99021, Y-27632 from Axon Medchem

Toyoda, T., Kimura, A., Tanaka, H., & Osafune, K. (2019). Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures. JoVE (Journal of Visualized Experiments), (145), e57641.
https://www.jove.com/video/57641/efficient-generation-pancreasduodenum-homeobox-protein-1-posterior

Goodrich, L. (2019). Mutational Analysis of Xist and the X-inactivation Center (Doctoral dissertation, UCSF).
https://escholarship.org/content/qt94k5n9jh/qt94k5n9jh.pdf

Heap, R. E., Segarra-Fas, A., Blain, A. P., Findlay, G. M., & Trost, M. (2019). Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: development of a reproducible and robust sample preparation workflow. Analyst, 144(21), 6371-6381.
https://pubs.rsc.org/en/content/articlehtml/2019/an/c9an00771g
2i: from Axon Medchem

De Clerck, L., Taelman, J., Popovic, M., Willems, S., Van der Jeught, M., Heindryckx, B., ... & Dhaenens, M. (2019). Untargeted histone profiling during naive conversion uncovers conserved modification markers between mouse and human. Scientific reports, 9(1), 1-11.
https://www.nature.com/articles/s41598-019-53681-6
* CHIR99021 and BIRB796 from Axon Medchem

Monzel, A. S., Hemmer, K., Mukendi, T. K., Lucarelli, P., Rosety, I., Zagare, A., ... & Azuaje, F. (2019). Machine learning-assisted neurotoxicity prediction in human midbrain organoids. bioRxiv, 774240.
https://www.biorxiv.org/content/10.1101/774240v1.abstract

Drowley, L., McPheat, J., Nordqvist, A., Peel, S., Karlsson, U., Martinsson, S., ... & Sánchez, J. (2019). Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach. Stem cells translational medicine.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/sctm.19-0069

Qiu, Q., Hu, P., Govek, K. W., Camara, P. G., & Wu, H. (2019). Massively parallel, time-resolved single-cell RNA sequencing with scNT-Seq. bioRxiv.
https://www.biorxiv.org/content/10.1101/2019.12.19.882050v1.full
2i: CHIR99021 and PD0325901 from Axon Medchem

Vanheer, L., Song, J., De Geest, N., Janiszewski, A., Talon, I., Provenzano, C., ... & Pasque, V. (2019). Tox4 modulates cell fate reprogramming. Journal of cell science, 132(20), jcs232223.
https://jcs.biologists.org/content/joces/132/20/jcs232223.full.pdf

S Tanigawa, H Naganuma, Y Kaku, T Era, T Sakuma, T Yamamoto, A Taguchi, R Nishinakamura. Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors. Stem Cell Reports. 2019, 13 (2), 322-337.
https://www.sciencedirect.com/science/article/pii/S2213671119302553

Otomo, N., Takeda, K., Kawai, S., Kou, I., Guo, L., Osawa, M., ... & Yasuhiko, Y. (2019). Bi-allelic loss of function variants of TBX6 causes a spectrum of malformation of spine and rib including congenital scoliosis and spondylocostal dysostosis. Journal of medical genetics, jmedgenet-2018.
https://www.ncbi.nlm.nih.gov/pubmed/31015262  

Yoshida, Y., Soma, T., Matsuzaki, T., & Kishimoto, J. (2019). Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin. Biochemical and biophysical research communications, 516(3), 599-605.
https://www.sciencedirect.com/science/article/pii/S0006291X19311611

Okuyama, H., Ohnishi, H., Nakamura, R., Yamashita, M., Kishimoto, Y., Tateya, I., ... & Omori, K. (2019). Transplantation of multiciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea. Journal of tissue engineering and regenerative medicine, 13(6), 1019-1030.
https://onlinelibrary.wiley.com/doi/abs/10.1002/term.2849

Dierickx, P., Emmett, M. J., Jiang, C., Uehara, K., Liu, M., Adlanmerini, M., & Lazar, M. A. (2019). SR9009 has REV-ERB–independent effects on cell proliferation and metabolism. Proceedings of the National Academy of Sciences, 116(25), 12147-12152.
https://www.pnas.org/content/116/25/12147
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Bluhmki, T., Traub, S., Schruf, E., Garnett, J., Gantner, F., Bischoff, D., & Heilker, R. (2019). Differentiation of hiPS Cells into Definitive Endoderm for High-Throughput Screening. In Cell-Based Assays Using iPSCs for Drug Development and Testing (pp. 101-115). Humana, New York, NY.
https://link.springer.com/protocol/10.1007/978-1-4939-9477-9_9

Minami, T., Ishii, T., Yasuchika, K., Fukumitsu, K., Ogiso, S., Miyauchi, Y., ... & Kawamoto, H. (2019). Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold. Regenerative therapy, 10, 127-133.
https://www.sciencedirect.com/science/article/pii/S235232041830107X

Malaguti, M., Migueles, R. P., Blin, G., Lin, C. Y., & Lowell, S. (2019). Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation. Developmental cell. 50(4), 462-477.
https://www.sciencedirect.com/science/article/pii/S1534580719304459
* CHIR99021, LDN193189 and PD0325901 from Axon Medchem

Yang, S., Ding, S., He, S., He, L., Gao, K., Peng, S., & Shuai, C. (2019). Differentiation of primordial germ cells from premature ovarian insufficiency-derived induced pluripotent stem cells. Stem cell research & therapy, 10(1), 156.
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1261-6

Weber, P., Rausch, C., Scholl, A., & Cardoso, M. C. (2019). Repli-FISH (Fluorescence in Situ Hybridization): Application of 3D-(Immuno)-FISH for the Study of DNA Replication Timing of Genetic Repeat Elements.
http://www.cardoso-lab.org/publications/Weber,%20Rausch%202019.pdf
*2i: CHIR99021 and PD0325901 from Axon Medchem

Hirabayashi, M., Takizawa, A., & Hochi, S. (2019). Embryonic Stem Cells and Gene Manipulation in Rat. In Rat Genomics (pp. 115-130). Humana, New York, NY.
https://link.springer.com/protocol/10.1007/978-1-4939-9581-3_5

Nakajima, M., Yoshimatsu, S., Sato, T., Nakamura, M., Okahara, J., Sasaki, E., ... & Okano, H. (2019). Establishment of induced pluripotent stem cells from common marmoset fibroblasts by RNA-based reprogramming. Biochemical and biophysical research communications.
https://www.sciencedirect.com/science/article/pii/S0006291X19310939

Saludas, L., Garbayo, E., Mazo, M., Abizanda, G., Garcia, O. I., Raya, A., ... & Blanco-prieto, M. J. (2019). Long-term engraftment of human cardiomyocytes combined with biodegradable microparticles induces heart repair. Journal of Pharmacology and Experimental Therapeutics, jpet-118.
http://jpet.aspetjournals.org/content/jpet/early/2019/02/06/jpet.118.256065.full.pdf
*CHIR99021 and C-59 from Axon Medchem

Wu, H., Vonk, K. K., van der Maarel, S. M., Santen, G. W., & Daxinger, L. (2019). A functional assay to classify ZBTB24 missense variants of unknown significance. Human mutation.
https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.23786
2i: CHIR99021 and PD0325901 from Axon Medchem

Smits, L. M., Reinhardt, L., Reinhardt, P., Glatza, M., Monzel, A. S., Stanslowsky, N., ... & Nicklas, S. M. (2019). Modeling Parkinson’s disease in midbrain-like organoids. NPJ Parkinson's disease, 5(1), 5.
https://www.nature.com/articles/s41531-019-0078-4

Cosset, E., Locatelli, M., Marteyn, A., Lescuyer, P., Antonia, F. D., Mor, F. M., ... & Tieng, V. (2019). Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases. JoVE (Journal of Visualized Experiments), (148), e59682.
https://www.jove.com/video/59682/human-neural-organoids-for-studying-brain-cancer-neurodegenerative
* CHIR99021 and LDN193189 from Axon Medchem

An, S., Park, U. H., Moon, S., Kang, M., Youn, H., Hwang, J. T., ... & Um, S. J. (2019). Asxl1 ablation in mouse embryonic stem cells impairs neural differentiation without affecting self-renewal. Biochemical and biophysical research communications, 508(3), 907-913.
https://www.sciencedirect.com/science/article/pii/S0006291X18326901
* 3i: SU5402, PD184352 and CHIR99021 from Axon Medchem

Katsuda, T., Matsuzaki, J., Yamaguchi, T., Yamada, Y., Hosaka, K., Takeuchi, A., ... & Ochiya, T. (2019). Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes. BioRxiv, 601922.
https://www.biorxiv.org/content/10.1101/601922v1.abstract

Cao, X., Yakala, G. K., van den Hil, F. E., Cochrane, A., Mummery, C. L., & Orlova, V. V. (2019). Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives. Stem cell reports, 12(6), 1282-1297.
https://www.sciencedirect.com/science/article/pii/S2213671119301705

Bursch, F., Kalmbach, N., Naujock, M., Staege, S., Eggenschwiler, R., Abo-Rady, M., ... & Boeckers, T. M. (2019). Altered calcium dynamics and glutamate receptor properties in iPSC derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations. Human molecular genetics.
https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddz107/5492438

Schöneborn, H., Raudzus, F., Secret, E., Otten, N., Michel, A., Fresnais, J., ... & Heumann, R. (2019). Novel Tools towards Magnetic Guidance of Neurite Growth:(I) Guidance of Magnetic Nanoparticles into Neurite Extensions of Induced Human Neurons and In Vitro Functionalization with RAS Regulating Proteins. Journal of functional biomaterials, 10(3), 32.
https://www.mdpi.com/2079-4983/10/3/32

Duval, N., Vaslin, C., Barata, T. C., Frarma, Y., Contremoulins, V., Baudin, X., ... & Ribes, V. C. (2019). BMP4 patterns Smad activity and generates stereotyped cell fate organization in spinal organoids. Development, 146(14), dev175430.
https://dev.biologists.org/content/146/14/dev175430.full

Boonen, T. M. P. M. (2019). Development of a myocardial infarction model by the design of a miniaturized 3D culture platform (Master's thesis, University of Twente).
https://essay.utwente.nl/79975/1/Master%20thesis%20T.M.P.M.%20Boonen.pdf 
Azacytidines Directly in the Genome. Helvetica Chimica Acta, 102(3), e1800229.
https://onlinelibrary.wiley.com/doi/abs/10.1002/hlca.201800229
* 2i from Axon Medchem

Aizawa, E., 2019. Characterization of in vitro systems to generate oocytes and substitutes of sperm from pluripotent stem cells (Doctoral dissertation, ETH Zurich).
https://www.research-collection.ethz.ch/bitstream/handle/20.500.11850/391005/1/Dissertation_EishiAizawa.pdf
* 2i from Axon Medchem

Spada, F., Schiffers, S., Kirchner, A., Zhang, Y., Kosmatchev, O., Korytiakova, E., ... & Carell, T. (2019). Oxidative and non-oxidative active turnover of genomic methylcytosine in distinct pluripotent states. BioRxiv, 846584.
https://www.biorxiv.org/content/10.1101/846584v1.full
* Axon Medchem (CHIR, CGP, PD, IWR1)

Smits, L. M., Magni, S., Grzyb, K., Antony, P. M., Krüger, R., Skupin, A., ... & Schwamborn, J. (2019). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. bioRxiv, 589598.
https://www.biorxiv.org/content/10.1101/589598v1.abstract

Amit, I., David, L.A. and Meital, G.U.R.Y., Yeda Research and Development Co Ltd, 2019. Methods and kits for analyzing dna binding moieties attached to dna. U.S. Patent Application 16/319,499.
https://patents.google.com/patent/US20190203270A1/en
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Hill, R. J., & Crossan, G. P. (2019). DNA cross-link repair safeguards genomic stability during premeiotic germ cell development. Nature genetics, 51(8), 1283.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675612/
2i: Pd0325901 and CHIR99021 from Axon

Canizo, J. R., Rivolta, A. E. Y., Echegaray, C. V., Suvá, M., Alberio, V., Aller, J. F., ... & Alberio, R. (2019). A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos. BMC developmental biology, 19(1), 13.
https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861-019-0193-9
* PD0325901, GO6983 from Axon Medchem

Ooi, J., Langley, S. R., Xu, X., Utami, K. H., Sim, B., Huang, Y., ... & Low, D. (2019). Unbiased profiling of isogenic Huntington disease hPSC-derived CNS and peripheral cells reveals strong cell-type specificity of CAG length effects. Cell reports, 26(9), 2494-2508.
https://www.sciencedirect.com/science/article/pii/S2211124719301706

Larsen, S. (2019). PHENOTYPIC CHARACTERIZATION OF CELLULAR MODELS OF VPS35-ASSOCIATED MUTATION IN PARKINSON’S DISEASE (Doctoral dissertation, University of Luxembourg, Belvaux, Luxembourg).
https://orbilu.uni.lu/bitstream/10993/40938/1/Larsen_thesis_FSTC_2019_56.pdf

Postlmayr, A. (2019). DCK8–A New Modulator for X-Chromosome Inactivation (Doctoral dissertation, ETH Zurich).
https://www.research-collection.ethz.ch/bitstream/handle/20.500.11850/341767/1/PhDTHESISPostlmayr.pdf

Ripani, P. (2019). Synergy between thiazolides and glutathione-S-transferases in cell death induction in colorectal tumor cells (Doctoral dissertation).
https://kops.uni-konstanz.de/bitstream/handle/123456789/48634/Ripani_2-132onngy88tg9.pdf?sequence=3

García-Pérez, A. (2019). Generation of pacemaker cardiomyocytes based on hHCN4 overexpression in hiPSCs by the Sleeping Beauty transposon system (Doctoral dissertation).
https://refubium.fu-berlin.de/bitstream/handle/fub188/26224/FINAL_Thesis.pdf?sequence=1&isAllowed=y&save=y

Halsberghe, E. (2019). The Use of CRISPR/Cas9 to Study the Function of Pluripotency-Associated Genes in Human Embryonic Stem Cells (Doctoral dissertation, Ghent University).
https://lib.ugent.be/fulltxt/RUG01/002/782/982/RUG01-002782982_2019_0001_AC.pdf

Pegg, A. K. (2019). BMP signalling via Id proteins in mesoderm progenitor cell differentiation.
https://era.ed.ac.uk/bitstream/handle/1842/36159/Pegg2019.pdf?sequence=1&isAllowed=y

Ekberg, J., Hansson, M., Doehn, U., Hess, K. and Funa, N., Novo Nordisk AS and Takara Bio Europe AB, 2019. Generation of pancreatic endoderm from pluripotent stem cells using small molecules. U.S. Patent 10,221,392.
https://patents.google.com/patent/US10221392B2/en

Goto, T., Hara, H., Sanbo, M., Masaki, H., Sato, H., Yamaguchi, T., ... & Hirabayashi, M. (2019). Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats. Nature communications, 10(1), 451.
 
Tang, L., Yao, F., Wang, H., Wang, X., Shen, J., Dai, B., ... & Li, T. (2019). Inhibition of TRPC1 prevents cardiac hypertrophy via NF-κB signaling pathway in human pluripotent stem cell-derived cardiomyocytes. Journal of molecular and cellular cardiology, 126, 143-154.
*CHIR99021 and IWR-1 from Axon Medchem
 
Yoshimura, Y., Taguchi, A., & Nishinakamura, R. (2019). Generation of Three-Dimensional Nephrons from Mouse and Human Pluripotent Stem Cells. In Kidney Organogenesis (pp. 87-102). Humana Press, New York, NY.
 
OCHIYA, T; KATSUDA, T. Method for producing hepatic stem/precursor cells from mature hepatic cells using low-molecular-weight compound. U.S. Patent Application No 16/068,607, 2019.
*CHIR99021, PD0325901 and GSK269962A from Axon Medchem
 
Vila-Cejudo, M., Massafret, O., Santaló, J., & Ibáñez, E. (2019). Single blastomeres as a source of mouse embryonic stem cells: effect of genetic background, medium supplements, and signaling modulators on derivation efficiency. Journal of assisted reproduction and genetics, 36(1), 99-111.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Katsuda, T., & Ochiya, T. (2019). Chemically Induced Liver Progenitors (CLiPs): A Novel Cell Source for Hepatocytes and Biliary Epithelial Cells. In Hepatic Stem Cells (pp. 117-130). Humana Press, New York, NY.
 
Zviran, A., Mor, N., Rais, Y., Gingold, H., Peles, S., Chomsky, E., ... & Manor, Y. S. (2019). Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules. Cell stem cell, 24(2), 328-341.
*2i: CHIR99021 + PD0325901, and 10058-F4 from Axon Medchem
 
Stathakos, P., Jimenez-Moreno, N., Crompton, L., Nistor, P., Caldwell, M. A., & Lane, J. D. (2019). Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson’s Disease Research. In Autophagy (pp. 257-280). Humana Press, New York, NY.
 
Yoshimura, Y., Taguchi, A., Tanigawa, S., Yatsuda, J., Kamba, T., Takahashi, S., ... & Nishinakamura, R. (2019). Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells. Journal of the American Society of Nephrology, 30(2), 304-321.
 
Frank, S., Ahuja, G., Bartsch, D., Russ, N., Yao, W., Kuo, J. C. C., ... & Messling, J. E. (2019). yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs. Cell stem cell, 24(2), 318-327.
*CHIR99021 and Y27632 from Axon Medchem
 
An, S., Park, U. H., Moon, S., Kang, M., Youn, H., Hwang, J. T., ... & Um, S. J. (2019). Asxl1 ablation in mouse embryonic stem cells impairs neural differentiation without affecting self-renewal. Biochemical and biophysical research communications, 508(3), 907-913.
*3i: SU5402, PD0325901 and CHIR99021 from Axon Medchem
 
Duval, N., Vaslin, C., Barata, T. C., Nedelec, S., & Ribes, V. C. (2019). BMP4 patterns Smad activity and generates stereotyped cell fate organisation in spinal organoids. bioRxiv, 511899.
 
Kuo, J. C. C., Derks, J. P., Akhade, V. S., Kargapolova, Y., Vargas, N. E., Kuroczik, A., ... & Sachinidis, A. (2019). yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs. Cell Stem Cell, 24, 1-10.
*CHIR99021 and Y27632 from Axon Medchem
 
Khateb, M., Azriel, A., & Levi, B. Z. (2019). The Third Intron of IRF8 Is a Cell-Type-Specific Chromatin Priming Element during Mouse Embryonal Stem Cell Differentiation. Journal of molecular biology, 431(2), 210-222.
*2i: PD0325910 and CHIR99021 from Axon Medchem
 
Heap, R. E., Fas, A. S., Findlay, G., & Trost, M. (2019). Profiling embryonic stem cell differentiation by MALDI-MS: development of a reproducible and robust sample preparation workflow. bioRxiv, 536664.
*2i: PD0325901 and CHIR99021 from Axon Medchem
 
Madeja, Z. E., Warzych, E., Pawlak, P., & Lechniak, D. (2019). Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications.
*2i: CHIR99021, PD0325901, PD184352, SU5402 from Axon Medchem
 
Rooijers, K., Markodimitraki, C., Rang, F., de Vries, S., Chialastri, A., de Luca, K., ... & Dey, S. (2019). Simultaneous quantification of protein-DNA contacts and transcriptomes in single cells. bioRxiv, 529388.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
2018 (79 citations; with 15 highlighted publications (#) in prestigious journals)
# Metzis, V., Steinhauser, S., Pakanavicius, E., Gouti, M., Stamataki, D., Ivanovitch, K., ... & Luscombe, N. M. (2018). Nervous system regionalization entails axial allocation before neural differentiation. Cell, 175(4), 1105-1118.
 
# Sonnen, K. F., Lauschke, V. M., Uraji, J., Falk, H. J., Petersen, Y., Funk, M. C., ... & Aulehla, A. (2018). Modulation of phase shift between Wnt and Notch signaling oscillations controls mesoderm segmentation. Cell, 172(5), 1079-1090.
 
# Giulitti, S., Pellegrini, M., Zorzan, I., Martini, P., Gagliano, O., Mutarelli, M., ... & Martello, G. (2018). Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nature cell biology.
*6i: CHIR99021, PD0325901, GO6983, WH-4-023, SB590885, and Y27632 from Axon Medchem
 
# Bahat, A., Goldman, A., Zaltsman, Y., Khan, D. H., Halperin, C., Amzallag, E., ... & Schimmer, A. D. (2018). MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells. Nature communications, 9(1), 5132.
 
# Ito, Y., Nakamura, S., Sugimoto, N., Shigemori, T., Kato, Y., Ohno, M., ... & Eto, K. (2018). Turbulence activates platelet biogenesis to enable clinical scale ex vivo production. Cell, 174(3), 636-648.
*CHIR9901, LY294002, PRT4165, SB431542, IOX2 from Axon Medchem
 
# K.F. Sonnen, V.M. Lauschke, J. Uraji, H.J. Falk, Y. Petersen, M.C.Funk, M. Beaupeux, P. François, C.A. Merten, A. Aulehla. (2018). Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation.
Cell, 2018, 172(5), 1079-1090.e12
 
# Mor, N., Rais, Y., Sheban, D., Peles, S., Aguilera-Castrejon, A., Zviran, A., ... & Hanna J.H. (2018). Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. Cell stem cell. 23 (3), 412-425.e10
*CHIR99021, PD0325901, GO6983, CPG77675, Y27632, DBZ from Axon Medchem
 
# Barakat, T. S., Halbritter, F., Zhang, M., Rendeiro, A. F., Perenthaler, E., Bock, C., & Chambers, I. (2018). Functional dissection of the enhancer repertoire in human embryonic stem cells. Cell stem cell, 23(2), 276-288.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
# Peruzzotti-Jametti, L., Bernstock, J. D., Vicario, N., Costa, A. S., Kwok, C. K., Leonardi, T., ... & Mallucci, G. (2018). Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell.
 
# Sahakyan, A., Clement, K., Clowers, K. J., Erickson, A. R., Shioda, K., Gygi, S. P., ... & Hochedlinger. K. Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells. Nature Methods. 15, 732–740.
*CHIR99021, PD0325901, GO6983, Y27632, IM12, SB590885, WH4-023 .. from Axon Medchem
 
# Yasuda, S. Y., Ikeda, T., Shahsavarani, H., Yoshida, N., Nayer, B., Hino, M., ... & Hasegawa, K. (2018). Chemically defined and growth-factor-free culture system for the expansion and derivation of human pluripotent stem cells. Nature Biomedical Engineering, 2(3), 173.
 
# Senís, E., Mosteiro, L., Wilkening, S., Wiedtke, E., Nowrouzi, A., Afzal, S., ... & Grimm, D (2018). AAVvector-mediated in vivo reprogramming into pluripotency. Nature communications, 9(1), 2651.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
# Kilens, S., Meistermann, D., Moreno, D., Chariau, C., Gaignerie, A., Reignier, A., ... & Flippe, L. (2018). Parallel derivation of isogenic human primed and naive induced pluripotent stem cells. Nature communications, 9(1), 360.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
# Pfeiffer, M. J., Quaranta, R., Piccini, I., Fell, J., Rao, J., Röpke, A., ... & Greber, B. (2018). Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES. Nature communications, 9(1), 440.
 
# de Jesus, B. B., Marinho, S. P., Barros, S., Sousa-Franco, A., Alves-Vale, C., Carvalho, T., & Carmo-Fonseca, M. (2018). Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency. Nature communications, 9(1), 94.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Todaro, F., Campolo, F., Barrios, F., Pellegrini, M., Di Cesare, S., Tessarollo, L., ... & Dolci, S. (2018). Regulation of Kit expression in early mouse embryos and ES cells. STEM CELLS.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Heo, H. R., Song, H., Kim, H. R., Lee, J. E., Chung, Y. G., Kim, W. J., ... & Hong, S. H. (2018). Reprogramming mechanisms influence the maturation of hematopoietic progenitors from human pluripotent stem cells. Cell death & disease, 9(11), 1090.
 
Skvortsova, E. V., Sinenko, S. A., & Tomilin, A. N. (2018). Immortalized murine fibroblast cell lines are refractory to reprogramming to pluripotent state. Oncotarget, 9(81), 35241.
 
Berger, E., Magliaro, C., Paczia, N., Monzel, A. S., Antony, P., Linster, C. L., ... & Schwamborn, J. C. (2018). Millifluidic culture improves human midbrain organoid vitality and differentiation. Lab on a Chip, 18(20), 3172-3183.
 
YAZAWA, Masayuki; SONG, LouJin. Methods for Cardiac Differentiation of Human Induced Pluripotent Stem Cells. U.S. Patent Application No 15/755,812, 2018.
 
OSAFUNE, Kenji; TOYODA, Taro; KIMURA, Azuma. Method for producing pancreatic bud cells. U.S. Patent Application No 15/760,523, 2018.
*CHIR99021 and LDN193189 from Axon Medchem
 
Mae, S. I., Ryosaka, M., Toyoda, T., Matsuse, K., Oshima, Y., Tsujimoto, H., ... & Osafune, K. (2018). Generation of branching ureteric bud tissues from human pluripotent stem cells. Biochemical and biophysical research communications, 495(1), 954-961.
*CHIR99021 and LDN193189 from Axon Medchem
 
Kamenova, I., Mukherjee, P., Conic, S., Mueller, F., El-Saafin, F., Bardot, P., ... & Vincent, S. D. (2018). Co-translation drives the assembly of mammalian nuclear multisubunit complexes. bioRxiv, 419812.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Yuan, J., Ma, Y., Huang, T., Chen, Y., Peng, Y., Li, B., ... & Ding, Q. (2018). Genetic modulation of RNA splicing with a CRISPR-guided cytidine deaminase. Molecular cell, 72(2), 380-394.
 
Aguilar‐Bravo, B., Rodrigo‐Torres, D., Ariño, S., Coll, M., Pose, E., Blaya, D., ... & Dubuquoy, L. (2018). Ductular reaction cells display an inflammatory profile and recruit neutrophils in alcoholic hepatitis. Hepatology.
* CHIR99021, Y27632 and A83-01 from Axon Medchem
 
Hamanaka, S., Umino, A., Sato, H., Hayama, T., Yanagida, A., Mizuno, N., ... & Masaki, H. (2018). Generation of vascular endothelial cells and hematopoietic cells by blastocyst complementation. Stem cell reports, 11(4), 988-997.
 
BOLOGNIN, Silvia; MONZEL, Anna; SCHWAMBORN, Jens. Means and methods for generating midbrain organoids. U.S. Patent Application No 15/766,779, 2018.
 
Dwivedi, O. P., Lehtovirta, M., Hastoy, B., Chandra, V., Kleiner, S., Jain, D., ... & Hansson, O. (2018). Loss of ZnT8 function protects against diabetes by enhanced insulin secretion. bioRxiv, 436030.
 
Ghimire, S., Van der Jeught, M., Neupane, J., Roost, M. S., Anckaert, J., Popovic, M., ... & Menten, B. (2018). Comparative analysis of naive, primed and ground state pluripotency in mouse embryonic stem cells originating from the same genetic background. Scientific reports, 8(1), 5884.
Strakova, K., Kowalski-Jahn, M., Gybel, T., Valnohova, J., Dhople, V. M., Harnos, J., ... & Lindskog, C. (2018). Dishevelled enables casein kinase 1–mediated phosphorylation of Frizzled 6 required for cell membrane localization. Journal of Biological Chemistry, 293(48), 18477-18493.
 
Rehbach, K. (2018). Rapid semi-automated phenotypic assays for compound testing in patient-derived SPG4 neurons (Doctoral dissertation, Universitäts-und Landesbibliothek Bonn).
 
GÜNTHER, Katharina. Generation of early human neuroepithelial progenitors from primary cells for biomedical applications. 2018.
 
Van Haver, S. (2018). DEVELOPMENT OF A HUMAN EMBRYONIC STEM CELL BASED PLATFORM FOR NEUROBLASTOMA TUMOUR MODELLING (Doctoral dissertation, Ghent University).
*CHIR99021, LDN193189 ans SB431532 from Axon Medchem
 
Zviran, A., Mor, N., Rais, Y., Gingold, H., Peles, S., Chomsky, E., ... & Manor, Y. S. (2018). The Molecular and Functional Foundations of Conducive Somatic Cell Reprogramming to Ground State Pluripotency.
 
NAKATSUJI, Norio; MINAMI, Itsunari. Composition for promoting cardiac differentiation of pluripotent stem cell comprising EGFR inhibitor. U.S. Patent Application No 10/196,609, 2019.
 
GOTOH, Shimpei, et al. Method for inducing differentiation of alveolar epithelial cells. U.S. Patent Application No 15/555,183, 2018.
 
Duthoo, E. (2018). IN VITRO GENERATION OF STEM CELL DERIVED GAMETES (Doctoral dissertation, Ghent University).
*CHIR99021 and BIRB0796 from Axon Medchem
 
Foster, B. M., Stolz, P., Mulholland, C. B., Montoya, A., Kramer, H., Bultmann, S., & Bartke, T. (2018). Critical role of the UBL domain in stimulating the E3 ubiquitin ligase activity of UHRF1 toward chromatin. Molecular cell, 72(4), 739-752.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Bursch, F. (2018). Studies on pathomechanisms and novel therapies in amyotrophic lateral sclerosis (Doctoral dissertation, University of Veterinary Medicine Hannover).
 
TZAHOR, Eldad, et al. Methods, kits and devices for promoting cardiac regeneration. U.S. Patent Application No 15/147,178, 2018.
  
TZAHOR, Eldad, et al. Methods, kits and devices for promoting cardiac regeneration. U.S. Patent Application No 10/017,574, 2018.
 
HUCH ORTEGA, Meritxell; CAROLUS, Johannes. LIVER ORGANOID, USES THEREOF AND CULTURE METHOD FOR OBTAINING THEM. U.S. Patent Application No 15/665,363, 2018.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Cuartas-López, A. M., Hernández-Cuellar, C. E., & Gallego-Gómez, J. C. (2018). Disentangling the Role of PI3K/Akt, Rho GTPase and the Actin Cytoskeleton on Dengue Virus Infection. Virus Research, 256, 153-165
 
Mulholland, C. B., Traube, F. R., Parsa, E., Eckl, E. M., Schoenung, M., Modic, M., ... & Bultmann, S. (2018). Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency. bioRxiv, 281519.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Mulholland, C. B., Ryan, J., Qin, W., Bartoschek, M. D., Traube, F. R., Parsa, E., ... & Leonhardt, H. (2018). TET1 drives global DNA demethylation via DPPA3-mediated inhibition of maintenance methylation. bioRxiv, 321604.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Dahlmann, J., Awad, G., Dolny, C., Weinert, S., Richter, K., Fischer, K. D., ... & Kensah G. (2018). Generation of functional cardiomyocytes from rat embryonic and induced pluripotent stem cells using feeder-free expansion and differentiation in suspension culture. PloS one, 13(3), e0192652.
 
Nose, N., Werner, R. A., Ueda, Y., Günther, K., Lapa, C., Javadi, M. S., ... & Higuchi T. (2018). Metabolic substrate shift in human induced pluripotent stem cells during cardiac differentiation: Functional assessment using in vitro radionuclide uptake assay. International Journal of Cardiology. in press.
 
SHOJI, Masanobu. Method for producing dopaminergic neurons. U.S. Patent Application No 10/017,734, 2018.
*CHIR99021, LDN193189, SU5402, SB431542, PD184352, PD173074 ... from Axon Medchem
 
OSAFUNE, Kenji; KOTAKA, Maki. Hepatocyte induction method. U.S. Patent Application No 15/539,042, 2018.
 
Shen, J., Wang, X., Zhou, D., Li, T., Tang, L., Gong, T., ... & Liang, P. (2018). Modelling cadmium‐induced cardiotoxicity using human pluripotent stem cell‐derived cardiomyocytes. Journal of cellular and molecular medicine.
*CHIR99021 and IWR-1 from Axon Medchem
 
Hoshina, A., Kawamoto, T., Sueta, S. I., Mae, S. I., Araoka, T., Tanaka, H., ... & Osafune, K. (2018). Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers. Scientific reports, 8(1), 6375.
 
Song, J., Janiszewski, A., De Geest, N., Vanheer, L., Talon, I., Oh, T., & Pasque, V. (2018). Two Active X-chromosomes Modulate the Growth, Pluripotency Exit and DNA Methylation Landscape of Mouse Naive Pluripotent Stem Cells through Different Pathways. bioRxiv, 291450.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Mor, N., Rais, Y., Peles, S., Sheban, D., Aguilera-Castrejon, A., Zviran, A., ... & Hanna J. H. (2018). Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD complex facilitates deterministic induction of naive pluripotency.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Ghimire, S., Van der Jeught, M., Neupane, J., Roost, M. S., Anckaert, J., Popovic, M., ... & Heindryckx, B. (2018). Comparative analysis of naive, primed and ground state pluripotency in mouse embryonic stem cells originating from the same genetic background. Scientific reports, 8(1), 5884.
 
Hsu, F., Spannl, S., Ferguson, C., Hyman, A. A., Parton, R. G., & Zerial, M. (2018). Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. eLife, 7, e32282.
 
GOTOH, Shimpei, et al. Method for inducing differentiation of airway epithelial cells. U.S. Patent Application No 15/558,670, 2018.
 
van der Wal, E., Herrero-Hernandez, P., Wan, R., & Broeders, M. Stijn LM in’t Groen, Tom JM van Gestel, Wilfred FJ van IJcken, 5 Tom H. Cheung, 4 Ans T. van der Ploeg, 2, 3 Gerben J. Schaaf, and WWM Pim Pijnappel. Stem Cell Reports. 10, 1975–1990.
 
Lee, J., Matsuzawa, A., Shiura, H., Sutani, A., & Ishino, F. (2018). Preferable in vitro condition for maintaining faithful DNA methylation imprinting in mouse embryonic stem cells. Genes to Cells, 23(3), 146-160.
 
GOTOH, Shimpei, et al. Method for inducing differentiation of alveolar epithelial cells. U.S. Patent Application No 15/555,183, 2018.
 
Conic, S., Desplancq, D., Ferrand, A., Fischer, V., Heyer, V., San Martin, B. R., ... & Tora, L (2018). Imaging of native transcription factors and histone phosphorylation at high resolution in live cells. J. Cell Biol, 217(4), 1537-1552.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Row, R. H., Pegg, A., Kinney, B. A., Farr 3rd, G. H., Maves, L., Lowell, S., ... & Martin, B. L. (2018). BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity. Elife, 7, e31018.
 
木村瑞希. 細胞リプログラミングにおける WNT2/β‐catenin 経路の解析. 2018.
 
Sutherland, L., Ruhe, M., Gattegno-Ho, D., Mann, K., Greaves, J., Koscielniak, M., ... & Tsakiridis, A. (2018). LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein. J Cell Sci, jcs-222257.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Nett, I. R., Mulas, C., Gatto, L., Lilley, K. S., & Smith, A. (2018). Negative feedback via RSK modulates Erk‐dependent progression from naïve pluripotency. EMBO reports, e45642.
*CHIR99021, PD0325901, BI-D1870 from Axon Medchem
 
Lynch, CJ. Bernad, R, Calvo, I, Nobrega-Pereira, S, Ruiz, S, Ibarz, N, Martinez-Val, A. Gran-Castro, O, Gomez-Lopez, G, s-Leo´ n, EA, Angarica, VE, del Sol, A, Ortega, S, Fernandez-Capetillo, O.Rojo, E, Munoz, J and Serrano, M. The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity. Cell Reports 22, 2018, 396–410. 
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
El-Saafin, F., Curry, C., Ye, T., Garnier, J. M., Kolb-Cheynel, I., Stierle, M., ... & Tora, L. (2018). Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription. Human molecular genetics, 27(12), 2171-2186.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
SATO, Toshiro; CLEVERS, Johannes C.; HUCH ORTEGA, Meritxell. CULTURE MEDIUM FOR EPITHELIAL STEM CELLS AND ORGANOIDS COMPRISING THE STEM CELLS. U.S. Patent Application No 15/654,243, 2018.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Yamauchi, K., Li, J., Morikawa, K., Liu, L., Shirayoshi, Y., Nakatsuji, N., ... & Suemori, H. (2018). Isolation and characterization of ventricular-like cells derived from NKX2-5eGFP/w and MLC2vmCherry/w double knock-in human pluripotent stem cells. Biochemical and biophysical research communications, 495(1), 1278-1284.
 
Messemaker, T. C., Leeuwen, S. M., Berg, P. R., EJ‘t Jong, A., Palstra, R. J., Hoeben, R. C., ... & Mikkers, H. M. (2018). Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot. Scientific reports, 8(1), 386.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., ... & Tamai, Y. (2018). The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles. Disease models & mechanisms, 11(1), dmm028779.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Toyoshima, H., Okazaki, Y., Yokoo, T., & Sugahara, I. (2018). Peptide and application thereof. U.S. Patent No. 9,856,304. Washington, DC: U.S. Patent and Trademark Office.
 
Katayama, M., Hirayama, T., Tani, T., Nishimori, K., Onuma, M., & Fukuda, T. (2018). Chick derived induced pluripotent stem cells by the poly‐cistronic transposon with enhanced transcriptional activity. Journal of cellular physiology, 233(2), 990-1004.
 
Jovanovic, V. M., Salti, A., Tilleman, H., Zega, K., Jukic, M. M., Zou, H., ... & Brodski, C. (2018). BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells. Journal of Neuroscience, 38(7), 1662-1676.
 
Sagner, A., Gaber, Z. B., Delile, J., Kong, J. H., Rousso, D. L., Pearson, C. A., ... & Novitch, B. G. (2018). Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS biology, 16(2), e2003127.
 
Yu, Y., Wang, X., Zhang, X., Zhai, Y., Lu, X., Ma, H., ... & Li, L. (2018). ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast. Stem cell research & therapy, 9(1), 2.
 
Zhu, H., Kimura, T., Swami, S., & Wu, J. Y. (2018). Pluripotent stem cells as a source of osteoblasts for bone tissue regeneration. Biomaterials.
 
Angarica, V. E., del Sol, A., Ortega, S., Fernandez-Capetillo, O., Rojo, E., Munoz, J., & Serrano, M. The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Mor, N., Rais, Y., Peles, S., Sheban, D., Aguilera-Castrejon, A., Zviran, A., ... & Zerbib, M. (2018). Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. bioRxiv, 192781.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
SR Braam, F STEVENHAGEN. Assays for measuring cardiotoxicity. US Patent App. 15/552,333, 2018
 
K.F. Sonnen, V.M. Lauschke, J. Uraji, H.J. Falk, Y. Petersen, M.C.Funk, M. Beaupeux, P. François, C.A. Merten, A. Aulehla. (2018). Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation.
Cell, 2018, 172(5), 1079-1090.e12
 
Peruzzotti-Jametti, L., Bernstock, J. D., Vicario, N., Costa, A. S., Kwok, C. K., Leonardi, T., ... & Mallucci, G. (2018). Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell.
 
Yamauchi, K., Li, J., Morikawa, K., Liu, L., Shirayoshi, Y., Nakatsuji, N., ... & Suemori, H. (2018). Isolation and characterization of ventricular-like cells derived from NKX2-5eGFP/w and MLC2vmCherry/w double knock-in human pluripotent stem cells. Biochemical and biophysical research communications, 495(1), 1278-1284.
 
Messemaker, T. C., Leeuwen, S. M., Berg, P. R., EJ‘t Jong, A., Palstra, R. J., Hoeben, R. C., ... & Mikkers, H. M. (2018). Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot. Scientific reports, 8(1), 386.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., ... & Tamai, Y. (2018). The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles. Disease models & mechanisms, 11(1), dmm028779.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Kilens, S., Meistermann, D., Moreno, D., Chariau, C., Gaignerie, A., Reignier, A., ... & Flippe, L. (2018). Parallel derivation of isogenic human primed and naive induced pluripotent stem cells. Nature communications, 9(1), 360.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Toyoshima, H., Okazaki, Y., Yokoo, T., & Sugahara, I. (2018). Peptide and application thereof. U.S. Patent No. 9,856,304. Washington, DC: U.S. Patent and Trademark Office.
 
Pfeiffer, M. J., Quaranta, R., Piccini, I., Fell, J., Rao, J., Röpke, A., ... & Greber, B. (2018). Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES. Nature communications, 9(1), 440.
 
Katayama, M., Hirayama, T., Tani, T., Nishimori, K., Onuma, M., & Fukuda, T. (2018). Chick derived induced pluripotent stem cells by the poly‐cistronic transposon with enhanced transcriptional activity. Journal of cellular physiology, 233(2), 990-1004.
 
Jovanovic, V. M., Salti, A., Tilleman, H., Zega, K., Jukic, M. M., Zou, H., ... & Brodski, C. (2018). BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells. Journal of Neuroscience, 38(7), 1662-1676.
 
Sagner, A., Gaber, Z. B., Delile, J., Kong, J. H., Rousso, D. L., Pearson, C. A., ... & Novitch, B. G. (2018). Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS biology, 16(2), e2003127.
 
Yu, Y., Wang, X., Zhang, X., Zhai, Y., Lu, X., Ma, H., ... & Li, L. (2018). ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast. Stem cell research & therapy, 9(1), 2.
 
Zhu, H., Kimura, T., Swami, S., & Wu, J. Y. (2018). Pluripotent stem cells as a source of osteoblasts for bone tissue regeneration. Biomaterials.
 
de Jesus, B. B., Marinho, S. P., Barros, S., Sousa-Franco, A., Alves-Vale, C., Carvalho, T., & Carmo-Fonseca, M. (2018). Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency. Nature communications, 9(1), 94.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Angarica, V. E., del Sol, A., Ortega, S., Fernandez-Capetillo, O., Rojo, E., Munoz, J., & Serrano, M. The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Mor, N., Rais, Y., Peles, S., Sheban, D., Aguilera-Castrejon, A., Zviran, A., ... & Zerbib, M. (2018). Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. bioRxiv, 192781.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
SR Braam, F STEVENHAGEN. Assays for measuring cardiotoxicity. US Patent App. 15/552,333, 2018
 
2017  (77 citations)
HIRABAYASHI, M., HARA, H., GOTO, T., TAKIZAWA, A., DWINELL, M. R., YAMANAKA, T., ... & NAKAUCHI, H. (2017). Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts. Journal of Reproduction and Development, 63(6), 611-616.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Osafune, K., & Toyoda, T. (2017). Method for producing pancreatic blast cells and pancreatic disease treatment agent containing pancreatic blast cells. U.S. Patent Application No. 15/311,759.
 
Trixl, L., Amort, T., Wille, A., Zinni, M., Ebner, S., Hechenberger, C., ... & Piatti, P. (2017). RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity. Cellular and Molecular Life Sciences, 1-15.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., ... & Tamai, Y. (2018). The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles. Disease models & mechanisms, 11(1), dmm028779.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Messemaker, T. C., Leeuwen, S. M., Berg, P. R., EJ‘t Jong, A., Palstra, R. J., Hoeben, R. C., ... & Mikkers, H. M. (2018). Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot. Scientific reports, 8(1), 386.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Fitzgerald, J. C., Zimprich, A., Carvajal Berrio, D. A., Schindler, K. M., Maurer, B., Schulte, C., ... & Bobbili, D. R. (2017). Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson’s disease. Brain, 140(9), 2444-2459.
 
Tang, L., Su, J., & Liang, P. (2017). Modeling cadmium-induced endothelial toxicity using human pluripotent stem cell-derived endothelial cells. Scientific reports, 7(1), 14811.
*CHIR99021 and IWR-1 from Axon Medchem
 
Pusapati, G. V., Kong, J. H., Patel, B. B., Krishnan, A., Sagner, A., Kinnebrew, M., ... & Rohatgi, R. (2017). CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Developmental cell.
*PD98059 and CHIR99021 from Axon Medchem
 
Raab, S., Klingenstein, M., Möller, A., Illing, A., Tosic, J., Breunig, M., ... & Kleger, A. (2017). Reprogramming to pluripotency does not require transition through a primitive streak-like state. Scientific reports, 7(1), 16543.
 
Karg, E., Smets, M., Ryan, J., Forné, I., Qin, W., Mulholland, C. B., ... & Leonhardt, H. (2017). Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells. Journal of molecular biology, 429(24), 3814-3824.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Matsuo, K., Sone, M., Honda-Kohmo, K., Toyohara, T., Sonoyama, T., Taura, D., ... & Ohta, A. (2017). Significance of dopamine D 1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells. Scientific reports, 7(1), 15120.
 
WANG, Jichang; IZSVÁK, Zsuzsanna; HURST, Laurence Daniel. Endogenous retrovirus transcription as a marker for primate naive pluripotent stem cells. U.S. Patent Application No 15/517,904, 2017.
*CHIR99021, PD0325901, SB2020190
 
TOYOSHIMA, Hideo, et al. Peptide and application thereof. U.S. Patent No 9,856,304, 2018.
 
Yamamoto, Y., Gotoh, S., Korogi, Y., Seki, M., Konishi, S., Ikeo, S., ... & Ito, I. (2017). Long-term expansion of alveolar stem cells derived from human iPS cells in organoids. Nature methods, 14(11), 1097.
 
BRAAM, Stefan Robbert; TEROOLEN, Leon; MUMMERY, Christine. Cardiomyocyte maturation. U.S. Patent Application No 15/316,341, 2017.
 
HASEGAWA, Kouichi, et al. Culture medium for pluripotent stem cells. U.S. Patent Application No 15/128,747, 2017.
 
Alzubi, J., Pallant, C., Mussolino, C., Howe, S. J., Thrasher, A. J., & Cathomen, T. (2017). Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model. Scientific Reports, 7(1), 12475.
 
Jacobs, E. Z., Warrier, S., Volders, P. J., D’haene, E., Van Lombergen, E., Vantomme, L., ... & Vergult, S. (2017). CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells. Scientific reports, 7(1), 16650.
 
de Jesus, B. B., Marinho, S. P., Barros, S., Sousa-Franco, A., Alves-Vale, C., Carvalho, T., & Carmo-Fonseca, M. (2018). Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency. Nature communications, 9(1), 94.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
HANNA, Yaqub; NOVERSHTERN, Noa; RAIS, Yoach. Media for culturing pluripotent stem cells. U.S. Patent Application No 15/500,163, 2017.
*CHIR99021, BIO, PD0325901, PD98059, PD184352, BAY43-9006, Thiazovivin, CGP77675, DAPT, DBZ, LY2886762, RU-SKI43, LDN193189, K02288, Dosomorphine, BIRB796, AEG3482, SB203580, SB202190, LY 2228820, PD169316 etc. from Axon Medchem
 
Braet, H. (2017). ANALYSIS OF THE GENOMIC STABILITY OF HUMAN EMBRYONIC STEM CELLS IN DIFFERENT STATES OF PLURIPOTENCY (Doctoral dissertation, Ghent University).
*CHIR99021 and BIR796 from Axon Medchem
 
SCHOELER, Hans R., et al. Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons. U.S. Patent Application No 15/233,561, 2017.
 
Katsuda, T., Hosaka, K., & Ochiya, T. (2017). Generation of Chemically Induced Liver Progenitors (CLiPs) from Rat Adult Hepatocytes. Cell Stem Cell.
 
Lee, J., Matsuzawa, A., Shiura, H., Sutani, A., & Ishino, F. (2018). Preferable in vitro condition for maintaining faithful DNA methylation imprinting in mouse embryonic stem cells. Genes to Cells.
 
VUNJAK-NOVAKOVIC, Gordana, et al. Engineered adult-like human heart tissue. U.S. Patent Application No 15/151,751, 2017.
 
ORTEGA, Meritxell Huch; CLEVERS, Johannes Carolus. Liver organoid, uses thereof and culture method for obtaining them. U.S. Patent No 9,765,301, 2017.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Warrier, S., Van der Jeught, M., Duggal, G., Tilleman, L., Sutherland, E., Taelman, J., ... & Peelman, L. (2017). Direct comparison of distinct naive pluripotent states in human embryonic stem cells. Nature Communications, 8: 15055.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413953/

Hohwieler, M., Illing, A., Hermann, P. C., Mayer, T., Stockmann, M., Perkhofer, L., ... & Kuo, C. C. (2017). Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling. Gut, 66(3), 473-486.
See: http://gut.bmj.com/content/66/3/473
*Chir99021 and SB431542 from Axon Medchem

Yamaguchi, T., Sato, H., Kato-Itoh, M., Goto, T., Hara, H., Sanbo, M., ... & Ota, Y. (2017). Interspecies organogenesis generates autologous functional islets. Nature, 542(7640), 191-196.
https://www.nature.com/nature/journal/v542/n7640/abs/nature21070.html
*2i: CHIR99021 and PD0325901 from Axon Medchem

Kawamata, M., Katsuda, T., Yamada, Y., & Ochiya, T. (2017). In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules. Biochemical and Biophysical Research Communications, 482(4), 750-757.
See: http://www.sciencedirect.com/science/article/pii/S0006291X16319805
*2i: CHIR99021 and PD0325901 from Axon Medchem

Nigro, A. L., Prosper, F., & Aranguren, X. L. (2017). Generation of a Sprague-Dawley-GFP rat iPS cell line. Stem Cell Research. 2017, 21, 47-50.
https://www.researchgate.net/profile/Antonio_Lo_Nigro/publication/316029625_Generation_of_a_Sprague-Dawley-GFP_rat_iPS_cell_line/links/58f770f6aca272649886fda3/Generation-of-a-Sprague-Dawley-GFP-rat-iPS-cell-line.pdf
*2i: CHIR99021 and PD0325901 from Axon Medchem

Stryjewska, A., Dries, R., Pieters, T., Verstappen, G., Conidi, A., Coddens, K., ... & van Grunsven, L. A. (2017). Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells. Stem Cells, 35(3), 611-625.
See: http://onlinelibrary.wiley.com/doi/10.1002/stem.2521/full
*2i: CHIR99021 and PD0325901 from Axon Medchem

Coppiello, G., Abizanda, G., Aguado, N., Iglesias, E., Iglesias-Garcia, O., Nigro, A. L., ... & Aranguren, X. L. (2017). Generation of a Sprague-Dawley-GFP rat iPS cell line. Stem Cell Research. 21, 40-43.
See: http://www.sciencedirect.com/science/article/pii/S187350611730065X
*2i: CHIR99021 and PD0325901 from Axon Medchem

Coppiello, G., Abizanda, G., Aguado, N., Iglesias, E., Iglesias-Garcia, O., Nigro, A. L., ... & Aranguren, X. L. (2017). Isolation and characterization of Sprague-Dawley and Wistar Kyoto GFP rat embryonic stem cells. Stem Cell Research. 21, 47-50.
See: http://www.sciencedirect.com/science/article/pii/S1873506117300648
*2i: CHIR99021 and PD0325901 from Axon Medchem

Yang, S., Ding, S., Xu, Q., Li, X., & Xiong, Q. (2017). Genetic Manipulation by Zinc-Finger Nucleases in Rat-Induced Pluripotent Stem Cells. Cellular Reprogramming (Formerly" Cloning and Stem Cells"). 19(3): 180-188.
See: http://online.liebertpub.com/doi/abs/10.1089/cell.2016.0028

Yoshimura, Y., Taguchi, A., & Nishinakamura, R. (2017). Generation of a Three-Dimensional Kidney Structure from Pluripotent Stem Cells. Organ Regeneration: 3D Stem Cell Culture & Manipulation, 179-193.
See: https://link.springer.com/protocol/10.1007/978-1-4939-6949-4_13

Kwok, C. K., Ueda, Y., Kadari, A., Günther, K., Heron, A., Schnitzler, A. C., ... & Edenhofer, F. (2017). Scalable stirred suspension culture for the generation of billions of human induced pluripotent stem cells using single‐use bioreactors. Journal of Tissue Engineering and Regenerative Medicine.
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Hosokawa, Y., Toyoda, T., Fukui, K., Baden, M. Y., Funato, M., Kondo, Y., ... & Watanabe, A. (2017). Insulin‐producing cells derived from ‘induced pluripotent stem cells’ of patients with fulminant type 1 diabetes: vulnerability to cytokine insults and increased expression of apoptosis‐related genes. Journal of Diabetes Investigation. DOI: 10.1111/jdi.12727
http://onlinelibrary.wiley.com/doi/10.1111/jdi.12727/full

Tosti, L., Ashmore, J., Tan, B. S. N., Carbone, B., Mistri, T. K., Wilson, V., ... & Kaji, K. (2017). Mapping transcription factor occupancy using minimal numbers of cells in vitro and in vivo. bioRxiv, 158931.
http://www.biorxiv.org/content/early/2017/07/03/158931.full.pdf+html
*2i: CHIR99021 and PD0325901 from Axon Medchem

Ludwig, A. K., Zhang, P., Hastert, F. D., Meyer, S., Rausch, C., Herce, H. D., ... & Storm, C. (2017). Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise. Nucleic acids research, 45(5), 2438-2457.
https://academic.oup.com/nar/article/45/5/2438/2638395/Binding-of-MBD-proteins-to-DNA-blocks-Tet1
*2i: CHIR99021 and PD0325901 from Axon Medchem*

Pieters, T., Haenebalcke, L., Bruneel, K., Vandamme, N., Hochepied, T., van Hengel, J., ... & Goossens, S. (2017). Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange. JoVE (Journal of Visualized Experiments), (122), e55575-e55575.
https://www.jove.com/video/55575/structure-function-studies-mouse-embryonic-stem-cells-using
*2i: CHIR99021 and PD0325901 from Axon Medchem

Zhang, P., Rausch, C., Hastert, F. D., Boneva, B., Filatova, A., Patil, S. J., ... & Cardoso, M. C. (2017). Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. Nucleic Acids Research.
https://academic.oup.com/nar/article/3752492
*2i: CHIR99021 and PD0325901 from Axon Medchem

Ziegenhain, C., Vieth, B., Parekh, S., Reinius, B., Guillaumet-Adkins, A., Smets, M., ... & Enard, W. (2017). Comparative analysis of single-cell RNA sequencing methods. Molecular cell, 65(4), 631-643.
http://www.sciencedirect.com/science/article/pii/S1097276517300497
*2i: CHIR99021 and PD0325901 from Axon Medchem

Monzel, A. S., Smits, L. M., Hemmer, K., Hachi, S., Moreno, E. L., van Wuellen, T., ... & Berger, E. (2017). Derivation of human midbrain-specific organoids from neuroepithelial Stem Cells. Stem cell reports, 8(5), 1144-1154.
http://www.sciencedirect.com/science/article/pii/S2213671117301169

Katsuda, T., Kawamata, M., Hagiwara, K., Takahashi, R. U., Yamamoto, Y., Camargo, F. D., & Ochiya, T. (2017). Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity. Cell stem cell, 20(1), 41-55.
http://www.sciencedirect.com/science/article/pii/S1934590916303472
*2i: CHIR99021 and PD0325901 from Axon Medchem

Cirelli, E., De Domenico, E., Botti, F., Massoud, R., Geremia, R., & Grimaldi, P. (2017). Effect Of Microgravity On Aromatase Expression In Sertoli Cells. Scientific Reports, 2017; 7: 3469.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471225/

Böscke, R., Vladar, E. K., Könnecke, M., Hüsing, B., Linke, R., Pries, R., ... & Wollenberg, B. (2017). Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps. American journal of respiratory cell and molecular biology, 56(5), 575-584.
http://www.atsjournals.org/doi/abs/10.1165/rcmb.2016-0024OC

KATAYAMA, M., HIRAYAMA, T., KIYONO, T., ONUMA, M., TANI, T., TAKEDA, S., ... & FUKUDA, T. (2017). Immortalized prairie vole-derived fibroblasts (VMF-K4DTs) can be transformed into pluripotent stem cells and provide a useful tool with which to determine optimal reprogramming conditions. Journal of Reproduction and Development, 2016-164.
https://www.jstage.jst.go.jp/article/jrd/advpub/0/advpub_2016-164/_article

A.S. Monzel, L.M. Smits, K. Hemmer, S. Hachi, E. L. Moreno,
T. van Wuellen, J. Jarazo, J. Walter, I. Bruggemann, I Boussaad, E. Berger,
R. M. Fleming, S. Bolognin, and J. C. Schwamborn. Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Stem Cell Reports. 2017, 8, 1144–1154.
http://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(17)30116-9

Anton, T., & Bultmann, S. (2017). Site-specific recruitment of epigenetic factors with a modular CRISPR/Cas system. Nucleus, 1-8.
http://www.tandfonline.com/doi/full/10.1080/19491034.2017.1292194?scroll=top&needAccess=true
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Hirsch, C., Striegl, B., Mathes, S., Adlhart, C., Edelmann, M., Bono, E., ... & Nyffeler, J. (2017). Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants. Archives of toxicology, 91(1), 407-425.
https://link.springer.com/article/10.1007/s00204-016-1680-4

Katayama, M., Hirayama, T., Tani, T., Nishimori, K., Onuma, M., & Fukuda, T. (2017). Chick derived induced pluripotent stem cells by the poly‐cistronic transposon with enhanced transcriptional activity. Journal of Cellular Physiology.
http://onlinelibrary.wiley.com/doi/10.1002/jcp.25947/full

van der Wal, E., Bergsma, A. J., van Gestel, T. J., LM, S., Zaehres, H., Araúzo-Bravo, M. J., ... & Pijnappel, W. P. (2017). GAA Deficiency in Pompe Disease Is Alleviated by Exon Inclusion in iPSC-Derived Skeletal Muscle Cells. Molecular Therapy-Nucleic Acids, 7, 101-115.
http://www.sciencedirect.com/science/article/pii/S2162253117301403

Murakami, N., Imamura, K., Izumi, Y., Egawa, N., Tsukita, K., Enami, T., ... & Inoue, H. (2017). Proteasome impairment in neural cells derived from HMSN-P patient iPSCs. Molecular brain, 10(1), 7.
https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-017-0286-y

Ehrlich, M., Mozafari, S., Glatza, M., Starost, L., Velychko, S., Hallmann, A. L., ... & Marteyn, A. (2017). Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Proceedings of the National Academy of Sciences, 114(11), E2243-E2252.
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Gotoh, S. Generation of Alveolar Epithelial Spheroids via Isolated. Am. J. Physiol, 258, L134-L147.
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Giacomelli, E., Bellin, M., Sala, L., Van Meer, B. J., Tertoolen, L. G., Orlova, V. V., & Mummery, C. L. (2017). Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development, dev-143438.
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Gouti, M., Delile, J., Stamataki, D., Wymeersch, F. J., Huang, Y., Kleinjung, J., ... & Briscoe, J. (2017). A gene regulatory network balances neural and mesoderm specification during vertebrate trunk development. Developmental Cell, 41(3), 243-261.
http://www.sciencedirect.com/science/article/pii/S1534580717302952

Hoffmann, D., Schott, J. W., Geis, F. K., Lange, L., Müller, F. J., Lenz, D., ... & Schambach, A. (2017). Detailed comparison of retroviral vectors and promoter configurations for stable and high transgene expression in human induced pluripotent stem cells. Gene Therapy, 24(5), 298-307.
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Nguyen, T. P., & Sieg, S. F. (2017). TGF-β inhibits IL-7-induced proliferation in memory but not naive human CD4+ T cells. Journal of Leukocyte Biology, jlb-3A1216.
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Barakat, T. S., Halbritter, F., Zhang, M., Rendeiro, A. F., Bock, C., & Chambers, I. (2017). Functional dissection of the enhancer repertoire in human embryonic stem cells. bioRxiv, 146696.
http://www.biorxiv.org/content/early/2017/07/04/146696.full.pdf+html
*2i: CHIR99021 and PD0325901 from Axon Medchem

Chal, J., Al Tanoury, Z., Oginuma, M., Moncuquet, P., Gobert, B., Miyanari, A., ... & Garnier, J. M. (2017). Recapitulating Early Development Of Mouse Musculoskeletal Precursors Of The Paraxial Mesoderm In Vitro. bioRxiv, 140574.
http://www.biorxiv.org/content/early/2017/05/22/140574
* CHIR99021 and LDN193189 from Axon Medchem

Thanisch, K., Song, C., Engelkamp, D., Koch, J., Wang, A., Hallberg, E., ... & Solovei, I. (2017). Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering. Differentiation, 94, 58-70.
http://www.sciencedirect.com/science/article/pii/S0301468116301116
*2i: CHIR99021 and PD0325901 from Axon Medchem

Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., ... & Van Laake, L. W. (2017). Circadian networks in human embryonic stem cell‐derived cardiomyocytes. EMBO reports, e201743897.
http://www.sciencedirect.com/science/article/pii/S2213671116303009
*2i: CHIR99021 and PD0325901 from Axon Medchem

Nakatsuji, N., Minami, I., Uesugi, M., & Aiba, K. (2017). U.S. Patent No. 9,587,220. Washington, DC: U.S. Patent and Trademark Office.
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A. L. Nigro,* A. de Jaime-Soguero, R. Khoueiry, D. S. Cho, G. M. Ferlazzo, I. Perini, V. A. Escalona, X. L. Aranguren, S.M.C. de Sousa Lopes, K. P. Koh, P. Giulio Conaldi, W.-S. Hu, A. Zwijsen, F. Lluis, & C.M. Verfaillie.
PDGFRa+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors.
http://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(16)30300-9
*2i: CHIR99021 and PD0325901 from Axon Medchem

Zhang, P., Ludwig, A. K., Hastert, F. D., Rausch, C., Lehmkuhl, A., Hellmann, I., ... & Cardoso, M. C. (2017). L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins. Nucleus, (May 2017 accepted), 1-15.
http://www.tandfonline.com/doi/abs/10.1080/19491034.2017.1330238
*2i: CHIR99021 and PD0325901 from Axon Medchem

Amort, T., Rieder, D., Wille, A., Khokhlova-Cubberley, D., Riml, C., Trixl, L., ... & Lusser, A. (2017). Distinct 5-methylcytosine profiles in poly (A) RNA from mouse embryonic stem cells and brain. Genome biology, 18(1), 1.
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1139-1
*2i: CHIR99021 and PD0325901 from Axon Medchem

Uliassi, E., Gandini, A., Perone, R. C., & Bolognesi, M. L. (2017). Neuroregeneration versus neurodegeneration: toward a paradigm shift in Alzheimer's disease drug discovery.
https://www.future-science.com/doi/abs/10.4155/fmc-2017-0038

Kondo, Y., Toyoda, T., Ito, R., Funato, M., Hosokawa, Y., Matsui, S., ... & Watanabe, A. (2017). Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia, 1-13.
https://link.springer.com/article/10.1007/s00125-017-4302-7

Ashida, Y., Nakajima‐Koyama, M., Hirota, A., Yamamoto, T., & Nishida, E. (2017). Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cells. Genes to Cells, 22(2), 189-202.
http://onlinelibrary.wiley.com/doi/10.1111/gtc.12467/full

Glover, J. D., Wells, K. L., Matthäus, F., Painter, K. J., Ho, W., Riddell, J., ... & Mort, R. L. (2017). Hierarchical patterning modes orchestrate hair follicle morphogenesis. PLoS biology, 15(7), e2002117.
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002117

Marczenke, M., Piccini, I., Mengarelli, I., Fell, J., Röpke, A., Seebohm, G., ... & Greber, B. (2017). Cardiac Subtype-Specific Modeling of Kv1. 5 Ion Channel Deficiency Using Human Pluripotent Stem Cells. Frontiers in Physiology, 8.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498524/

Drouin‐Ouellet, J., Lau, S., Brattås, P. L., Ottosson, D. R., Pircs, K., Grassi, D. A., ... & Graff, C. (2017). REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and‐independent pathways. EMBO molecular medicine, 9(8), 1117-1131.
http://embomolmed.embopress.org/content/9/8/1117
*CHIR99021, SB431542 and LDN193189 from Axon Medchem

Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., ... & Van Laake, L. W. (2017). Circadian networks in human embryonic stem cell‐derived cardiomyocytes. EMBO reports, e201743897.
http://embor.embopress.org/content/early/2017/05/23/embr.201743897?utm_source=TrendMD&utm_medium=cpc&utm_campaign=EMBO_Rep_TrendMD_0

Jason, J. Y., Paranjape, S. R., Walker, M. P., Choudhury, R., Wolter, J. M., Fragola, G., ... & Zylka, M. J. (2017). The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome. Journal of Biological Chemistry, jbc-M117.
http://www.jbc.org/content/early/2017/05/30/jbc.M117.788448.short

Yi, J. J., Paranjape, S. R., Walker, M. P., Choudhury, R., Wolter, J. M., Fragola, G., ... & Zylka, M. J. (2017).
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.
JBC Papers in Press. Published on May 30, 2017 as Manuscript M117. 788448.
https://www.researchgate.net/publication/317261376_The_autism-linked_UBE3A_T485A_mutant_E3_ubiquitin_ligase_activates_the_Wntb-catenin_pathway_by_inhibiting_the_proteasome

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Matsuno, Kunihiko, et al. "Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells." Differentiation (2016).
http://www.sciencedirect.com/science/article/pii/S0301468116300238
*CHIR99021 and LDN193189 were purchased from Axon Medchem.

Meek, Stephen, et al. "Reduced levels of dopamine and altered metabolism in brains ofHPRTknock-out rats: a new rodent model of Lesch-Nyhan Disease." Scientific reports 6 (2016): 25592.
http://www.nature.com/articles/srep25592
2i:CHIR99021 and PD0325901 were purchased from Axon Medchem 

Vrij, Erik, et al. "Directed Assembly and Development of Material‐Free Tissues with Complex Architectures." Advanced Materials (2016).
http://onlinelibrary.wiley.com/doi/10.1002/adma.201505723/full 

Becker, Matthias, et al. "Polycomb proteinBMI1 regulates osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells downstream of GSK3." Stem cells and development (2016).
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Sudheer, Smita, et al. "Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT‐Induced Presomitic Mesoderm."STEMCELLS (2016).
http://onlinelibrary.wiley.com/doi/10.1002/stem.2371/abstract
2i:CHIR99021 and PD0325901 were from Axon Medchem. 

Kugler, Josephine, et al. "Identification and characterization of teratogenic chemicals using embryonic stem cells isolated from a Wnt/β-Catenin-reporter transgenic mouse line." Toxicological Sciences (2016): kfw094.
http://toxsci.oxfordjournals.org/content/early/2016/05/19/toxsci.kfw094.abstract
*CHIR99021 and XAV939 from Axon Medchem

Huang, Jijun, et al. "Coupling switch of P2Y-IP3 receptors mediates differential Ca2+ signaling in human embryonic stem cells and derived cardiovascular progenitor cells." Purinergic signalling (2016): 1-14.
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Rivron, Nicolas Clément, et al. "BLASTOID,CELLLINEBASED ARTIFICIAL BLASTOCYST."U.S.Patent No. 20,160,060,593.3 Mar. 2016.
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Den Hartogh, Sabine C. "Fluorescent gene reporters in human pluripotent stem cells: as model for studying human heart development and cardiomyocyte differentiation." (2016).
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Braam, Stefan Robbert. "CULTURE MEDIUM COMPOSITION FOR MATURATING CARDIOMYOCYTES DERIVED FROM PLURIPOTENT MAMMALIANSTEMCELLS."U.S.Patent No. 20,160,122,718. 5 May 2016.
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Hara, Hiromasa, et al. "Rat Blastocysts from Nuclear Infection and Time-Lagged Enucleation and Their Commitment to Embryonic Stem Cells." Cellular Reprogramming (Formerly" Cloning and Stem Cells") 18.2 (2016): 108-115.
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V Schwach et al. Generation and purification of human stem cell-derived cardiomyocytes.
Differentiation. 2016 Feb 22. pii: S0301-4681(16)30002-0.

H Neumann et al. Polysialic acid and use for treatment of neurodegenerative and neuroinflammatory diseases.
U.S. Patent 20,160,046,734.
(CHIR99021, SB431542 and Compound E(BZ) from Axon Medchem)

C Hirsch et al. Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants.
Arch Toxicol. 2016 Feb 29. [Epub ahead of print]
(2i:CHIR99021 and PD0325901 from Axon Medchem)

M Naujock et al. 4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from ALSPatient-Derived Induced Pluripotent Stem Cells.
Stem Cells. 2016 Mar 6. [Epub ahead of print]

J. Wang et al. Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression. 
Nat Protoc. 2016 Feb;11(2):327-46.
(2i:CHIR99021 and PD0325901 from Axon Medchem)

B. Linnartz‐Gerlachet al. Sialylation of neurites inhibits complement‐mediated macrophage removal in a human macrophage‐neuron Co‐Culture System.
Glia. 2016 Jan;64(1):35-47.
(CHIR99021 and SB431542 from Axon Medchem) 

N. Nakatsuji et al. COMPOSITION FOR PROMOTING CARDIAC DIFFERENTIATION OF PLURIPOTENT STEMCELLCOMPRISING EGFR INHIBITOR.
U.S. Patent 20,160,002,600, issued January 7, 2016.

E.J. Vrij et al.. 3D High Throughput Screening and profiling of Embryoid Bodies in thermoformed microwell plates.
Lab Chip. 2016 Jan 18.

C. Ziegenhain et al. Comparative analysis of single-cell RNA-sequencing methods.
bioRxiv (2016): 035758.
(2i:CHIR99021 and PD0325901 from Axon Medchem)

B.C.Heng et al. An overview of protocols for the neural induction of dental and oral stem cells in vitro.
Tissue Eng Part B Rev. 2016 Jan 12.
(2i:CHIR99021 and PD0325901 from Axon Medchem)

2015  (53 citations)
J Chal et al. Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.
Nature Biotechnology 33, 962–969 (2015)

I.J. Huijbers et al.Using the GEMM-ESC strategy to study gene function in mouse models.
Nat Protoc. 2015 Nov;10(11):1755-85.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

M.J. Birket et al. Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells.
Nat Biotechnol. 2015 Sep;33(9):970-9.

H. Kawano et al. Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway.
Oncol Rep. 2015 Nov;34(5):2251-8.
(2i from Axon Medchem: CHIR99021 and PD0325901)

A. Kirkeby et al. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
C. Parish et al (Ed.) Developing stem cell-based therapies for neural repair.  Frontiers Media 2015, ISBN 2889194027, 9782889194025
(Y27632 and CHIR99021 from Axon Medchem)

H. Iseki et al. Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
Stem Cells. 2015 Nov 2.
(2i: CHIR99021 and PD0325901 from Axon Medchm)

S. Haraguchi et al. Chick embryos can form teratomas from microinjected mouse embryonic stem cells.
Dev Growth Differ. 2015 Dec 22.

C.W. van den Berg et al. Differentiation of human pluripotent stem cells to cardiomyocytes under defined conditions.
Methods Mol Biol. 2016;1353:163-80.

M. Ehrlich et al. Distinct neurodegenerative changes in an induced pluripotent stem cell model of frontotemporal dementia linked to mutant tau protein.
Stem Cell Reports. 2015 Jul 14;5(1):83-96.

G. Duggal et al. Alternative routes to induce naïve pluripotency in human embryonic stem cells.
Stem Cells. 2015 Sep;33(9):2686-98.

A. Shahraz et al. Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages.
Sci Rep. 2015 Nov 19;5:16800.
(CHIR99021, SB431542 and Compound E (DBZ) from Axon Medchem)

T. Palm et al. Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.
Sci Rep. 2015 Nov 6;5:16321.

L. Braunschweig et al. Oxygen regulates proliferation of neural stem cells through Wnt/β-catenin signalling.
Mol Cell Neurosci. 2015 Jul;67:84-92.

M.V. Krivega et al. Cyclin E1 plays a key role in balancing between totipotency and differentiation in human embryonic cells.
Mol Hum Reprod. 2015 Dec;21(12):942-56

B. Watmuff et al. Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling.
Front Cell Neurosci. 2015 Mar 31;9:104.

S. Meyer et al. Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells.
J Vis Exp. 2015 Jul 29;(101):e52831.

Y. Tabata et al. Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells.
J Biomol Screen. 2015 Oct;20(9):1074-83.

Z.E. Madeja et al. WNT/β-Catenin Signaling Affects Cell Lineage and Pluripotency-Specific Gene Expression in Bovine Blastocysts: Prospects for Bovine Embryonic Stem Cell Derivation.
Stem Cells Dev. 2015 Oct 15;24(20):2437-54.

T. Miura et al. Generation of primitive neural stem cells from human fibroblasts using a defined set of factors.
Biol Open. 2015 Oct 21;4(11):1595-607.

J. Rao et al. Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.
Cell Stem Cell. 2015 Dec 29. pii: S1934-5909(15)00517-2.

J. Chen et al. Evolutionary analysis across mammals reveals distinct classes of long noncoding RNAs.
bioRxiv, 2015 p.031385.

H.D. Devalla et al. Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology.
EMBO Mol Med. 2015 Feb 19;7(4):394-410.

B. Mühl et al. SPREDs (Sprouty Related Proteins with EVH1 Domain) promote self‐renewal and inhibit mesodermal differentiation in murine embryonic stem cells.
Dev Dyn. 2015 Apr;244(4):591-606.

B. Roese-Koerner. 2015. MicroRNAs in neural stem cell proliferation and differentiation
Doctoral dissertation, Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Diss., 2015.
(CHIR99021 and LDN193189 from Axon Medchem)

M. Zhang et al. Universal Cardiac Induction of Human Pluripotent Stem Cells in Two and Three‐Dimensional Formats: Implications for In Vitro Maturation.
Stem Cells. 2015 May;33(5):1456-69.

M. Hosoya et al. Method of producing pancreatic hormone-producing cells.
U.S. Patent 9157069 (B2)

A. Kamiya et al. MEK-ERK Activity Regulates the Proliferative Activity of Fetal Hepatoblasts Through Accumulation of p16/19cdkn2a.
Stem Cells Dev. 2015 Nov 1;24(21):2525-35.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation.
Van der Jeught M, Taelman J, Duggal G, Ghimire S, Lierman S, Chuva de Sousa Lopes SM., Deforce D, Deroo T, De Sutter P, Heindryckx B. 
Cell. Reprogram. 2015, 17(3): 170-180. doi:10.1089/cell.2014.0085.

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.
D’Uva, G., Aharonov, A., Lauriola, M., Kain, D., Yahalom-Ronen, Y., Carvalho, S., ... & Tzahor, E. (2015).
Nature Cell Biology 2015, 17, 627–638. doi:10.1038/ncb3149

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Bartfeld, S., Bayram, T., van de Wetering, M., Huch, M., Begthel, H., Kujala, P., ... & Clevers, H. (2015).
Gastroenterology, 148(1), 126-136.

DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes.
Cohen, I. S., Bar, C., Paz-Elizur, T., Ainbinder, E., Leopold, K., de Wind, N., ... & Livneh, Z.
Nucleic acids research, 2015, 43(3), 1637-1645.
*2i: CHIR99021 and PD0325901 from Axon Medchem

piggyBac Transposon-Based Insertional Mutagenesis in Mouse Haploid Embryonic Stem Cells.
Pettitt, S. J., Tan, E. P., & Yusa, K. (2015).
Chromosomal Mutagenesis, Methods in Meolecular Biology. 2015, Vol. 1239, pp. 15-28. Springer New York.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro–Correlation between contraction force and electrophysiology.
Ribeiro, M. C., Tertoolen, L. G., Guadix, J. A., Bellin, M., Kosmidis, G., D'Aniello, C., ... & Passier, R. (2015).
Biomaterials. 2015 May;51:138-50. doi: 10.1016/j.biomaterials.2015.01.067. Epub 2015 Feb 18. 

Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells.
Toyoda, T., Mae, S. I., Tanaka, H., Kondo, Y., Funato, M., Hosokawa, Y., ... & Osafune, K. (2015).
Stem cell research, 2015, 14(2), 185-197.

Generation of Rat Induced Pluripotent Stem Cells Using a Plasmid Vector and Possible Application of a Keratan Sulfate Glycan Recognizing Antibody in Discriminating Teratoma Formation Phenotypes.
Makanga, J. O., Kobayashi, M., Ikeda, H., Christianto, A., Toyoda, H., Yamada, M., ... & Inazu, T. (2015).
Biological and Pharmaceutical Bulletin, 38(1), 127-133. 

A modular open platform for systematic functional studies under physiological conditions.
Mulholland, C. B., Smets, M., Schmidtmann, E., Leidescher, S., Markaki, Y., Hofweber, M., ... & Bultmann, S. (2015).
Nucleic Acids Res. 2015 May 24. pii: gkv550. [Epub ahead of print]
*2i: CHIR99021 and PD0325901 from Axon Medchem

Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.
Yang, J., Wang, W., Ooi, J., Campos, L. S., Lu, L., & Liu, P.
STEM CELLS, 2015, 33(5), 1390-1404.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Dual Reporter MESP1mCherry/w‐NKX2‐5eGFP/w hESCs Enable Studying Early Human Cardiac Differentiation.
Den Hartogh, S. C., Schreurs, C., Monshouwer‐Kloots, J. J., Davis, R. P., Elliott, D. A., Mummery, C. L., & Passier, R. (2015).
Stem Cells. 2015 Jan;33(1):56-67. doi: 10.1002/stem.1842. 

Establishment of Tsc2‑deficient rat embryonic stem cells.
Ito, Y., Kawano, H., Kanai, F., Nakamura, E., Tada, N., Takai, S., ... & Hino, O.
International journal of oncology, 2015, 46(5), 1944-1952.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Establishment and Use of Mouse Haploid ES Cells.
Leeb, M., Perry, A. C., & Wutz, A.
Current Protocols in Mouse Biology, 2015, 155-185.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Functional Compensation Between Myc and PI3K Signaling Supports Self‐Renewal of Embryonic Stem Cells.
Hishida, T., Nakachi, Y., Mizuno, Y., Katano, M., Okazaki, Y., Ema, M., ... & Okuda, A.
Stem Cells, 2015, 33(3), 713-725.
Read more: http://onlinelibrary.wiley.com/doi/10.1002/stem.1893/full
*2i: CHIR99021 and PD0325901 from Axon Medchem

Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy.
Friedrichs, S., Malan, D., Voss, Y., & Sasse, P. (2015).
Journal of Clinical Medicine, 4(1), 102-123.
*CHIR99021 and PD184352 from Axon Medchem 

Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells.
Masaki, H., Kato-Itoh, M., Umino, A., Sato, H., Hamanaka, S., Kobayashi, T., ... & Nakauchi, H. (2015).
Development. 2015 May 28. pii: dev.124016. [Epub ahead of print] 

Embryonic stem cell differentiation requires full length Chd1.
Piatti, P., Lim, C. Y., Nat, R., Villunger, A., Geley, S., Shue, Y. T., ... & Lusser, A.
Sci Rep. 2015 Jan 26;5:8007. doi: 10.1038/srep08007.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.
Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, et al.
PLoS Genet 11(5): e1005239. doi:10.1371/journal.pgen.1005239
*3i: SB431542, CHIR99021 and PD0325901 from Axon Medchem 

Funktionelle Analyse der Histon-Demethylase UTX in hämatopoetisch differenzierenden murinen ES-Zellen.
Kampka, J. (2015).
Doctoral dissertation of Julius-Maximilians-Universität Würzburg.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Universal Cardiac Induction of Human Pluripotent Stem Cells in Two and Three‐Dimensional Formats: Implications for In Vitro Maturation.
Zhang, M., Schulte, J. S., Heinick, A., Piccini, I., Rao, J., Quaranta, R., ... & Greber, B. (2015).
Stem Cells. 2015 May;33(5):1456-69. doi: 10.1002/stem.1964. 

Method for manufacturing pancreatic-hormone-producing cells.
Hosoya, M., Kunisada, Y., Shoji, M., & Yamazoe, N. (2015).
U.S. Patent No. 8932853.
*CHIR98014, CHIR99021, TDZD-8, SB216763, BIO, TWS-119, and SB415286 were purchased from Axon Medchem

A Protocol for Lentiviral Transduction and Downstream Analysis of Intestinal Organoids.
de Jeude, JFVL., Vermeulen, JL, Montenegro-Miranda, PS, Van den Brink, GR, & Heijmans, J.
J. Vis. Exp. (JoVE) 2015, 98, e52531-e52531. doi:10.3791/5253 

Successful Reprogramming of Epiblast Stem Cells by Blocking Nuclear Localization of β-Catenin.
Murayama, H., Masaki, H., Sato, H., Hayama, T., Yamaguchi, T., & Nakauchi, H. (2015).
Stem cell reports 4.1 (2015): 103-113.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Gene activation-associated long noncoding RNAs function in mouse preimplantation development.
Hamazaki, N., Uesaka, M., Nakashima, K., Agata, K., & Imamura, T. 
Development. 2015 Mar 1;142(5):910-20. doi: 10.1242/dev.116996. Epub 2015 Jan 29.

Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells.
Kurek, D., Neagu, A., Tastemel, M., Tüysüz, N., Lehmann, J., van de Werken, H. J., ... & ten Berge, D.
Stem Cell Reports. 2015, 4, 114-118.

2014 (38 citations)
YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response.
L Azzolin, T Panciera, S Soligo, E Enzo, S Bicciato, S Dupont, S Bresolin, C Frasson, G Basso, V Guzzardo, A Fassina, M Cordenonsi, S Piccolo.
Cell, 2014, 158 (1), 157-170. doi:10.1016/j.cell.2014.06.013
*CHIR99021 from Axon Medchem has been used in this study.

Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions.
van den Berg, C. W., Elliott, D. A., Braam, S. R., Mummery, C. L., & Davis, R. P. (2014). 
Methods in Molecular Biology, 10, 7651_2014_178.

Molecular and Functional Analyses of Motor Neurons Generated from Human Cord-Blood-Derived Induced Pluripotent Stem Cells. 
Naujock, M., Stanslowsky, N., Reinhardt, P., Sterneckert, J., Haase, A., Martin, U., ... & Petri, S. (2014). 
Stem cells and development, 23(24), 3011-3020.

Epigenetic Characterization of the FMR1 Promoter in Induced Pluripotent Stem Cells from Human Fibroblasts Carrying an Unmethylated Full Mutation.
de Esch, C. E., Ghazvini, M., Loos, F., Schelling-Kazaryan, N., Widagdo, W., Munshi, S. T., ... & Willemsen.
Stem Cell Reports. 2014, 3, 548–555.
* PD0325901 (1μM, ERK1/2i, Axon 1408); CHIR99021 (3μM, GSK3i, Axon 1386); SB203580 (10 μM, p38i, Axon 1363) Y-27632 (5μM, Axon 1683) from Axon Medchem.

A screen for transcription factor targets of Glycogen Synthase Kinase-3 highlights an inverse correlation of NFκB and Androgen Receptor Signaling in Prostate Cancer.
Campa, V. M., Baltziskueta, E., Bengoa-Vergniory, N., Gorroño-Etxebarria, I., Wesołowski, R., Waxman, J., & Kypta, R. M.
Oncotarget. 2014 Sep; 5(18): 8173–8187.

Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain. 
Hargus, G., Ehrlich, M., Araúzo-Bravo, M. J., Hemmer, K., Hallmann, A. L., Reinhardt, P., ... & Zaehres, H. (2014). 
Cell reports, 8(6), 1697-1703.

Erk Signaling Suppresses Embryonic Stem Cell SelfRenewal to Specify Endoderm.
Hamilton, W. B., & Brickman, J. M. 
Cell report, 2014, 9(6), 2056–2070.
*2i: CHIR99021 and PD0325901 from Axon Medchem 

Isolated naive pluripotent stem cells and methods of generating same.
Hanna, Yaqub, Noa Novershtern, and Yoach Rais. (2014).
US Patent Application 14/259,997. US 20140315301 A1
*2i CHIR99021 and PD0325901 and 20 other compounds from Axon Medchem

The role of chromatin organization and structure in neuronal differentiation.
Weng, M. K. 2014
PhD Thesis

Targeted organ generation using Mixl1-inducible mouse pluripotent stem cells in blastocyst complementation. 
Kobayashi, T., Kato-Itoh, M., & Nakauchi, H. (2014). 
Stem cells and development, 24(2), 182-189.
*2i used in this study and CHIR99021 from Axon Medchem

Direct Neural Conversion from Human Fibroblasts Using Self-Regulating and Nonintegrating Viral Vectors. 
Lau, S., Ottosson, D. R., Jakobsson, J., & Parmar, M. 
Cell reports, 2014, 9(5), 1673-1680.
*CHIR99021 and LDN193189 from Axon Medchem

Gene Targeting Study Reveals Unexpected Expression of Brain expressed X-linked 2 in Endocrine and Tissue Stem/progenitor Cells in Mice.
K Ito, S Yamazaki, R Yamamoto, Y Tajima, A Yanagida, T Kobayashi, M Kato-Itoh, S Kakuta, Y Iwakura, H Nakauchi and A Kamiya*.
J Biol Chem. 2014 Oct 24;289(43):29892-911. doi: 10.1074/jbc.M114.580084. Epub 2014 Aug 20.
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) were procured from Axon Medchem. 

The Generation and Maintenance of Rat Induced Pluripotent Stem Cells.
T Yamaguchi, S Hamanaka, H Nakauchi.
Stem Cells and Tissue Repair. Methods in Molecular Biology. 2014, 1210, 143-150. Date: 06 Aug 2014
*2i used and CHIR99021 from Axon Medchem

Dual reporter MESP1mCherry/w-NKX2-5eGFP/w hESCs enable studying early human cardiac differentiation.
SC Den Hartogh, C Schreurs, JJ Monshouwer-Kloots, RP Davis1, DA Elliott, C Mummery and R Passier.
Stem Cells. 2015 Jan;33(1):56-67. doi: 10.1002/stem.1842.

CULTURE MEDIA FOR STEM CELLS.
JC Clevers, T Sato, M Huch Ortega, W Richard.
US Patent Application 20140243227.
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) from Axon Medchem 

Identifying Nuclear Protein–Protein Interactions Using GFP Affinity Purification and SILAC-Based Quantitative Mass Spectrometry.
HI Baymaz, CG Spruijt, M Vermeulen.
Methods in Molecular Biology 2014, 1188, 207-226.
2i inhibitors (Axon Medchem, CHIR99021 and PD0325901 

Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells.
S Gotoh, I Ito, T Nagasaki, Y Yamamoto, S Konishi, Y Korogi, H Matsumoto, S Muro, T Hirai, M Funato, SI Mae, T Toyoda, A Sato-Otsubo, S Ogawa, K Osafune, M Mishima.
Stem Cell Reports, 2014, in press. DOI: 10.1016/j.stemcr.2014.07.005

Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.
C Dambrot, SR Braam, LGJ Tertoolen, M Birket, DE Atsma and CL Mummery.
J. Cell. Mol. Med., 2014, online 1 Jul 2014. DOI: 10.1111/jcmm.12356

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer.
AR Palla, D Piazzolla, M Abad, H Li, O Dominguez, HB Schonthaler, EF Wagner and M Serrano.
Oncogene 2014, 33, 2513–2519.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) from Axon Medchem 

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.
D Piazzolla, AR Palla, C Pantoja, M Cañamero… & M Serrano*.
Nature Communications, 2014, 5 (4226), in press. doi:10.1038/ncomms5226
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) are procured from Axon Medchem.

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation.
U Müller, C Bauer, M Siegl, A Rottach, H Leonhardt*
Nucl. Acids Res. (2014) online Jun 19, 2014. doi: 10.1093/nar/gku552
2i: PD0325901 (Axon 1408) and CHIR99021 (Axon 1386) 

Development of FGF2-dependent pluripotent stem cells showing naive state characteristics from murine preimplantation inner cell mass.
M Ozawa, E Kawakami, R Sakamoto, T Shibasaki, A Gotoa, N Yoshida.
Stem Cell Res. 2014, 13 (1), 75–87.  DOI: 10.1016/j.scr.2014.04.012
Read more: http://www.sciencedirect.com/science/article/pii/S1873506114000488 

Effect of Leukemia Inhibitory Factor and Forskolin on Establishment of Rat Embryonic Stem Cell Lines.
M Hirabayashi, C TAMURA, M SANBO, H HARA, S Hochi.
J. Reprod. Devel. 2014, 60 (1), 78-82.  doi:  10.1262/jrd.2013-109

Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.
PK Shah, MP Walker, CE Sims, MB Major, NL Allbritton*
Integr. Biol.,2014, 6, 673-684.  DOI: 10.1039/C4IB00050A

Stepwise Differentiation of Pluripotent Stem Cells into Osteoblasts Using Four Small Molecules under Serum-free and Feeder-free Conditions.
K Kanke, H Masaki, T Saito, Y Komiyama, H Hojo, H Nakauchi, AC Lichtler, T Takato, U Chung, S Ohba.
Stem Cell Reports. 2014 May 22;2(6):751-60. doi: 10.1016/j.stemcr.2014.04.016. eCollection 2014.

The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele.
Y Shetzer, S Kagan, G Koifman, R Sarig, I Kogan-Sakin, M Charni, T Kaufman, M Zapatka, A Molchadsky, N Rivlin, N Dinowitz, S Levin, G Landan, I Goldstein, N Goldfinger, D Pe'er, B Radlwimmer, P Lichter, V Rotter and R Aloni-Grinstein. - nature.com
Cell Death & Differentiation, 2014, (16 May 2014) | doi:10.1038/cdd.2014.57

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
T Pfaffeneder, F Spada, M Wagner, C Brandmayr, SK Laube, D Eisen, M Truss, J Steinbacher, B Hackner, O Kotljarova, D Schuermann, S Michalakis, Olesea Kosmatchev, S Schiesser, B Steigenberger, N Raddaoui, G Kashiwazaki, U Müller, CG Spruijt, M Vermeulen, H Leonhardt, P Schär, M Müller & T Carell.
Nat Chem Biol. 2014 Jul;10(7):574-81. doi: 10.1038/nchembio.1532. Epub 2014 May 18.

Citrullination regulates pluripotency and histone H1 binding to chromatin.
MA Christophorou, G Castelo-Branco, RP Halley-Stott, CS Oliveira, R Loos, A Radzisheuskaya, KA Mowen, P Bertone, JCR Silva, M Zernicka-Goetz, ML Nielsen, JB Gurdon & T Kouzarides.
Nature 507, 104–108 (06 March 2014) doi:10.1038/nature12942
*both PD0325901 and CHIR99021 from Axon Medchem

FIREWACh: High-throughput Functional Detection of Transcriptional Regulatory Modules in Mammalian Cells.
M Murtha, Z Tokcaer-Keskin, Z Tang, F Strino, X Chen, Y Wang, X Xi, C Basilico, S Brown, R Bonneau, Y Kluger, and L Dailey.
Nat Methods. 2014 May;11(5):559-65. doi: 10.1038/nmeth.2885. Epub 2014 Mar 23.
*2i, PD0325901, 1 μM and CHIR99021, 3 μM from Axon Medchem 

Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.
D Smeets, Y Markaki, VJ Schmid, F Kraus, Anna Tattermusch, A Cerase, M Sterr, S Fiedler, J Demmerle, J Popken, H Leonhardt, N Brockdorff, T Cremer, L Schermelleh, M Cremer.
Epigenetics & Chromatin 2014, 7:8
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) from Axon Medchem 

IL-13 Orchestrates Resolution of Chronic Intestinal Inflammation via Phosphorylation of Glycogen Synthase Kinase-3β. 
S Fichtner-Feigl, R Kesselring, M Martin, F Obermeier, P Ruemmele, A Kitani, SM Brunner, M Haimer, EK Geissler, W Strober & HJ Schlitt. 
J Immunol. 2014 Apr 15;192(8):3969-80. doi: 10.4049/jimmunol.1301072. Epub 2014 Mar 14.

Engineering of midbrain organoids containing long-lived dopaminergic neurons. 
Tieng, V., Stoppini, L., Villy, S., Fathi, M., Dubois-Dauphin, M., & Krause, K. H. 
Stem Cells Dev. 2014 Jul 1;23(13):1535-47. doi: 10.1089/scd.2013.0442. Epub 2014 Apr 3.

Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells.
IJ Huijbers, RB Ali, C Pritchard, M Cozijnsen, MCh Kwon, N Proost, JY Song, H de Vries, J Badhai, K Sutherland, P Krimpenfort, EM Michalak, J Jonkers, A Berns.
EMBO Mol Med. 2014 Feb;6(2):212-25. doi: 10.1002/emmm.201303297. Epub 2014 Jan 8.
*2i, PD0325901 and CHIR99021 from Axon Medchem

Rapid identification of targeted transgene integrations in ES cells by fluorescence detection.
S Kautschitsch, L Andersen, S Hammerschmid, & T Rülicke.
Transgenic Res. 2014 Jun;23(3):469-75. doi: 10.1007/s11248-014-9782-3. Epub 2014 Jan 31.
*2i, MEK inhibitor PD0325901, 1 μM and GSK3 inhibitor CHIR99021, 3 μM from Axon Medchem 

GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. 
Enochson, L., Stenberg, J., Brittberg, M., & Lindahl, A. 
Osteoarthritis Cartilage. 2014 Apr;22(4):566-77. doi: 10.1016/j.joca.2014.02.004. Epub 2014 Feb 19.

Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.
GJ Litherland, W Hui, MS Elias, DJ Wilkinson, S Watson, C Huesa, DA Young and AD Rowan.
Arthritis Rheumatol. 2014 Aug;66(8):2175-87. doi: 10.1002/art.38681.

INDUCED MALIGNANT STEM CELLS.
T Ishikawa
US Patent 20140137274A1.
*CHIR99021, PD184352, SU5402, PD174074, PD0325901, BIO etc from Axon Medchem 

2013 (29 citations)
Derivation of novel human ground state naive pluripotent stem cells.
O Gafni, L Weinberger, AA Mansour, YS Manor, E Chomsky, D Ben-Yosef, Y Kalma, S Viukov, I Maza, A Zviran, Y Rais,  Z Shipony, Z Mukamel, V Krupalnik, M Zerbib, S Geula, I Caspi, D Schneir, T Shwartz, S Gilad, D Amann-Zalcenstein, S Benjamin, I Amit, A Tanay, R Massarwa, N Novershtern & JH Hanna.
Nature 2013, Published online 30 October 2013.  doi:10.1038/nature12745
Read more: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12745.html?WT.ec_id=NATURE-20131031
*CHIR99021 (Axon 1386), PD0325901 (Axon 1408), SB202190 (Axon 1364), BIRB796 (Axon 1358), Y-27632 (Axon 1693) used in this study were procured from Axon Medchem.
** SB203580 (Axon 1363) was also procured in large amount by Weizman Inst from Axon Medchem, however, this drug was noted from another supplier in the paper. 

Targeting and tracing of specific DNA sequences with dTALEs in living cells. 
Thanisch, K., Schneider, K., Morbitzer, R., Solovei, I., Lahaye, T., Bultmann, S., & Leonhardt, H. 
Nucleic acids research, 2013, gkt1348. doi: 10.1093/nar/gkt1348
See: http://nar.oxfordjournals.org/content/early/2013/12/25/nar.gkt1348.short
*2i: PD0325901 and CHIR99021 from Axon Medchem

Identification of Ccr4-Not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
M Kamon, M Katano, K Hiraki-Kamon, T Hishida, Y Nakachi, Y Mizuno, Y Okazaki, A Suzuki, M Hirasaki, A Ueda, M Nishimoto, H Kato, and A Okuda. 
Stem Cells Develop. 2013, ahead of print. doi:10.1089/scd.2013.0326.
Read more: http://online.liebertpub.com/doi/abs/10.1089/scd.2013.0326 

Deterministic direct reprogramming of somatic cells to pluripotency. 
Y Rais, A Zviran, S Geula, O Gafni, E Chomsky, S Viukov, AA Mansour, I Caspi, V Krupalnik, M Zerbib, I Maza, N Mor, D Baran, L Weinberger, DA Jaitin, D Lara-Astiaso, R Blecher-Gonen, Z Shipony, Z Mukamel, T Hagai, S Gilad, D Amann-Zalcenstein, ATanay, I Amit, N Novershtern & JH Hanna. 
Nature, 2013, 502 (7469), 65-70.
Read more: http://www.nature.com/nature/journal/v502/n7469/abs/nature12587.html 

The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.
A Kumar, T Torii, Y Ishino, D Muraoka, T Yoshimura, A Togayachi, H Narimatsu, K Ikenaka and S Hitoshi.
J. Biol. Chem. published online August 28, 2013
Read more: http://www.jbc.org/content/early/2013/08/28/jbc.M113.469403.short 

Induced Pluripotent Stem Cells from Friedreich Ataxia Patients Fail to Up-regulate Frataxin during in vitro Differentiation to Peripheral Sensory Neurons.
A Eigentler, S Boesch, R Schneider, G Dechant, R Nat.
Stem Cells Develop. 2013, 22(24), 3271-3282. doi:10.1089/scd.2013.0126.
Read more: http://online.liebertpub.com/doi/abs/10.1089/scd.2013.0126 

Tuning of β‐catenin Activity is Required to Stabilise Self‐renewal of Rat Embryonic Stem Cells. 
S Meek, J Wei, L Sutherland, B Nilges, M Buehr, SR Tomlinson, AJ Thomson, T Burdon.
STEM CELLS. 2013, 31 (10), 2104-2115. DOI: 10.1002/stem.1466
Read more: http://onlinelibrary.wiley.com/doi/10.1002/stem.1466/abstract 

Characteristics of Bovine Inner Cell Mass-Derived Cell Lines and Their Fate in Chimeric Conceptuses.
T Furusawa, K Ohkoshi, K Kimura, S Matsuyama, S Akagi, M Kaneda, M Ikeda, M Hosoe, K Kizaki, and T Tokunaga.
Biol. Reprod. 2013, 2, 28. | doi: 10.1095/ biolreprod.112.106641
Read more: http://www.biolreprod.org/content/early/2013/06/14/biolreprod.112.106641.short
(* Both CHIR99021 and PD184352 are from Axon Medchem) 

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer
AR Palla, D Piazzolla, M Abad, H Li, O Dominguez, HB Schonthaler, EF Wagner and M Serrano.
Oncogene , (10 June 2013) | doi:10.1038/onc.2013.196
Read more: http://www.nature.com/onc/journal/vaop/ncurrent/abs/onc2013196a.html 

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.
P Wend, L Fang, Q Zhu, JH Schipper, C Loddenkemper, F Kosel, V Brinkmann, K Eckert, S Hindersin, JD Holland, S Lehr, M Kahn, U Ziebold and W Birchmeier.
EMBO J. 2013, 32 (14), 1977-1989.  | doi:10.1038/emboj.2013.127
Read more: http://www.nature.com/emboj/journal/vaop/ncurrent/full/emboj2013127a.html?elq=1b48832c832e4f24bddb3541aac89f67 

Epigenetic regulation of lentiviral and retroviral vectors in murine embryonic stem (ES) cells and genetic modification of ES cells with lentiviral vectors for application in regenerative medicine. 
TT LIM, 2013 PhD Thesis. Universitäts-und Landesbibliothek Bonn. (supervisors: A Pfeifer and DO Fürst)
Read more: http://hss.ulb.uni-bonn.de/2013/3253/3253.pdf 

Glycogen synthase kinase-3 (GSK-3) regulates TGF-β1-induced differentiation of pulmonary fibroblasts.
HA Baarsma, LHJM Engelbertink, LJ van Hees, MH Menzen, H Meurs, W Timens, DS Postma, HAM Kerstjens, R Gosens.
Br. J. Pharmacol. 2013, 169(3), 590-603. DOI: 10.1111/bph.12098
http://onlinelibrary.wiley.com/doi/10.1111/bph.12098/abstract 

Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal
endoderm, whereas Wnt/b-catenin signaling promotes differentiation into visceral endoderm.
I Chuykin, H Schulz, K Guan and M Bader.
J. Cell Sci. 2013, 126(1), 128-138. doi: 10.1242/jcs.110239
Read more: http://jcs.biologists.org/content/126/1/128.short 

Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules. 
N Liu, M Wang, W Deng, CS Schmidt, W Qin, H Leonhardt, F Spada. 
PLoS ONE 2013, 8(5): e62755. doi:10.1371/journal.pone.0062755
Read more: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062755 

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response.
J Heijmans, JF van Lidth de Jeude, BK Koo, SL Rosekrans, MCB Wielenga, M van de Wetering, M Ferrante, AS Lee, JJM Onderwater, JC Paton, AW Paton, AM Mommaas, LL Kodach, JC Hardwick, DW Hommes, H Clevers, V Muncan, GR van den Brink.
Cell Reports 2013, 3(4), 1128–1139.
Read more: http://www.sciencedirect.com/science/article/pii/S2211124713001071 

Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog.
V Karwacki-Neisius, J Göke, R Osorno, F Halbritter, JH Ng, AY Weiße, FCK Wong, A Gagliardi, NP Mullin, N Festuccia, D Colby, SR Tomlinson, HH Ng, I Chambers.
Cell Stem Cell 2013, 12(5), 531-545.
Read more: http://www.sciencedirect.com/science/article/pii/S1934590913001598 

Essential role of sox2 for the establishment and maintenance of the germ cell line.
F Campolo, M Gori, R Favaro, S Nicolis, M Pellegrini, F Botti, P Rossi, EA Jannini, S Dolci.
Stem Cells, 2013, online publication. DOI: 10.1002/stem.1392
Read more: http://onlinelibrary.wiley.com/doi/10.1002/stem.1392/abstract 

Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal. 
Y Sanchez-Ripoll, HK Bone, T Owen, AMV Guedes, E Abranches, B Kumpfmueller, RV Spriggs, D Henrique, MJ Welham.
PLoS ONE 2013, 8(4): e60148. doi:10.1371/journal.pone.0060148
Read more: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060148 

Deep proteome coverage based on ribosome profiling aids MS-based protein and peptide discovery and provides evidence of alternative translation products and near-cognate translation initiation events.
G Menschaert, W Van Criekinge, T Notelaers, A Koch, J Crappe, K Gevaert and P Van Damme.
Mol. Cell. Proteomics. 2013, 12, 1780-1790.  doi: 10.1074/mcp.M113.027540
http://www.mcponline.org/content/early/2013/02/21/mcp.M113.027540.short 

Derivation of a Germline Competent Transgenic Fischer 344 Embryonic Stem Cell Line
H Men, EC Bryda.
PLOS One 2013, 8(2): e56518. doi:10.1371/journal.pone.0056518
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056518 

Efficient Generation of Rat Induced Pluripotent Stem Cells Using a Non-Viral Inducible Vector.
C Merkl, A Saalfrank, N Riesen, R Kühn, A Pertek, S Eser, MS Hardt, A Kind, D Saur, W Wurst, A. Iglesias, A Schnieke.
PLoS ONE 2013, 8(1): e55170. doi:10.1371/journal.pone.0055170
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055170 

Efficient p53 gene targeting by homologous recombination in rat-induced pluripotent stem cells.
G Li, Y Chunxu, L Guisheng.
Cell Proliferation 2013, 46(1), 1–9.
http://onlinelibrary.wiley.com/doi/10.1111/cpr.12000/full 

Pharmacological Inhibition of Glycogen Synthase Kinase 3 Regulates T Cell Development In Vitro.
JH Schroeder, LS Bell, ML Janas, M Turner.
PLoS ONE 2013, 8(3): e58501. doi:10.1371/journal.pone.0058501
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058501 

Phosphoinositide-3-kinases p110α and p110β mediate S phase entry in astroglial cells in the marginal zone of rat neocortex.
R Müller, C Fischer, T Wilmes, B Heimrich, V Distel, N Klugbauer, DK Meyer.
Front. Cell Neurosci. 2013, 7, 24. doi:  10.3389/fncel.2013.00024 PMCID: PMC3596864
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596864/ 

Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling. 
P Reinhardt, M Glatza, K Hemmer, Y Tsytsyura, CS Thiel, S Höing, S Moritz, JA Parga, L Wagner, JM Bruder, G Wu, B Schmid, A Röpke, J Klingauf, JC Schwamborn, T Gasser, HR Schöler, J Sterneckert.
PLoS ONE 2013, 8(3): e59252. doi:10.1371/journal.pone.0059252
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059252 

A retrospective analysis of germline competence in rat embryonic stem cell lines.
M Hirabayashi, C Tamura, M Sanbo, M Kato-Itoh, T Kobayashi, H Nakauchi, & S Hochi. 
Transgenic Res. 2013, 22 (2), 411-416.
Read more: http://link.springer.com/article/10.1007/s11248-012-9638-7 

Derivation of porcine induced pluripotent stem cells and somatic cells gene targeting in pig.
Xinxin Cu, PhD thesis. TECHNISCHE UNIVERSITÄT MÜNCHEN, Lehrstuhl für Biotechnologie der Nutztiere.
See: http://mediatum.ub.tum.de/doc/1138162/1138162.pdf
*2i: PD0325901 and CHIR99021 from Axon Medchem

Liver organoid, uses thereof and culture method for obtaining them
MH Ortega, JC Clevers. US 20130189327 A1
Read more: http://www.google.com/patents/US20130189327 

METHOD FOR MANUFACTURING PANCREATIC-HORMONE-PRODUCING CELLS. 
M Hosoya, Y Kunisada, M Shoji, & N Yamazoe.
U.S. Patent No. 20,130,022,986. 24 Jan. 2013.
Read more: http://www.freepatentsonline.com/y2013/0022986.html 

(* 61 publications from 2009-2012, incomplete list extracted from >100 citations) 
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.
CA Lyssiotis, RK Foreman, J Staerk, M Garcia, D Mathur, S Markoulaki, J Hanna, LL Lairson, BD Charette, LC Bouchez, M Bollong, C Kunick, A Brinker, CY Cho, PG Schultz and R Jaenisch.
PNAS 2009, 106 (22), 8912-8917.  doi: 10.1073/pnas.0903860106[Citation: 205, till Apr 8, 2013] 

Selective GSK-3β inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells.
HJ Park, HJ Kim, GS Bae, SW Seo, DY Kim, WS Jung, MS Kim, MY Song, EK Kim, KB Kwon, SY Hwang, HJ Song, CS Park, RK Park, MS Chong, SJ Park. 
Hearing Res. 2009, 257 (1-2), 53-62. 

Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells.
MY Chang, D Kim, CH Kim, HC Kang, E Yang, et al. 
PLoS ONE 2010, 5(3): e9838.  doi:10.1371/journal.pone.0009838
(*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.
S Li, MS Brown, and JL Goldstein.
PNAS 2010, 107 (8), 3441-3446. Read more: http://www.pnas.org/content/107/8/3441.short 

Generation of genetically modified rats from embryonic stem cells.
Masaki Kawamata and Takahiro Ochiya
PNAS 2010, 107 (32), 14223-14228.  doi: 10.1073/pnas.1009582107
(*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Identification and regulation of glycogen synthase kinase-3 during bovine embryo development.
IM Aparicio, M Garcia-Herreros, T Fair and P Lonergan
Reproduction 2010, 140, 83-92.  doi: 10.1530/REP-10-0040
Read more: http://www.reproduction-online.org/content/140/1/83.short 

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4.
ML Janas, G Varano, K Gudmundsson, M Noda,T Nagasawa, M Turner. 
J. Exp. Medicine (JEM), 2010, 207 (1), 247. doi: 10.1084/jem.20091430  

Interactions of Wnt/β-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons.
M Tang, JC Villaescusa, SX Luo, C Guitarte, S Lei, Y Miyamoto, MM Taketo, E Arenas, and EJ Huang.
J. Neuroscience, 2010, 30 (27), 9280-9291.
Read more: http://www.jneurosci.org/content/30/27/9280.short 

Inhibition of GSK3β enhances both adhesive and signalling activities of β-catenin in mouse embryonic stem cells.
Galina S. Sineva*, Valery A. Pospelov.
Biol. Cell. 2010, 102 (10), 549-564. DOI: 10.1042/BC20100016 

The Skp2 Promoter Integrates Signaling through the NF-κB, p53, and Akt/GSK3β Pathways to Regulate Autophagy and Apoptosis.
B Barré and ND Perkins.
Mol. Cell 2010, 38 (4), 524–538.
Read more: http://www.sciencedirect.com/science/article/pii/S1097276510003242 

Distinct Developmental Ground States of Epiblast Stem Cell Lines Determine Different Pluripotency Features.
C Bernemann, B Greber, K Ko, J Sterneckert, DW Han, MJ Araúzo-Bravo, HR Schöler*
Stem Cells 2011, 29 (10), 1496-1503. (*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Generating gene knockout rats by homologous recombination in embryonic stem cells.
C Tong, G Huang, C Ashton, P Li , QL Ying*.
Nature Protocols 2011, 6, 827–844. 

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing.
B Zimmer, PB Kuegler, B Baudis… - nature.com
Cell Death and Differentiation 2011, 18, 383-395. 

Volatile anesthetic post-treatment induces protection via inhibition of glycogen synthase kinase 3 [beta] in human neuron-like cells.
D Lin, G Li, Z. Zuo.
Neuroscience 2011, 179, 73-79. 

Rat Embryonic Stem Cell Derivation and Propagation.
Ping Li, Eric N. Schulze, Chang Tong and Qi-Long Ying.
ADVANCED PROTOCOLS FOR ANIMAL TRANSGENESIS. Springer Protocols Handbooks, 2011, 457-475, DOI: 10.1007/978-3-642-20792-1_19 (*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Use of WNT stimulators for treating demyelinating diseases.
European Patent Application EP2305274 

Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: essential role of bone morphogenetic protein 4.
PM Chiang and PC Wong.
Development 2011, 138, 2833-2843. 

A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.
K Horie, C Kokubu, J Yoshida, K Akagi, A Isotani, A Oshitani, K Yusa, R Ikeda, Y Huang, A Bradley & J Takeda.
Nature Methods 2011, 8, 1071-1077. doi:10.1038/nmeth.1739
(*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Generation of germline-competent rat induced pluripotent stem cells.
S Hamanaka, T Yamaguchi, T Kobayashi, M Kato-Itoh, S Yamazaki et al. 
PLoS ONE 2011, 6(7): e22008. 

Glycogen synthase kinase-3 regulates cigarette smoke extract-and IL-1β-induced cytokine secretion by airway smooth muscle.
HA Baarsma, H Meurs, AJ Halayko, MH Menzen, M Schmidt, HAM Kerstjens, and R Gosens.
Am. J. Physiol. (AJP) - Lung Physiol 2011, 300 (6), L910-L919.
Read more: http://ajplung.physiology.org/content/300/6/L910.short 

Derivation, Characterization, and Stable Transfection of Induced Pluripotent Stem Cells from Fischer344 Rats.
M Liskovykh, I Chuykin, A Ranjan, D Safina, E Popova, E Tolkunova, V Mosienko, JM Minina, NS Zhdanova, JJ Mullins, M Bader, N Alenina*, A Tomilin*.
PLoS ONE 2011, 6(11): e27345. doi:10.1371/journal.pone.0027345. 

Rat Embryonic Stem Cells: Establishment and Their Use for Transgenesis.
M Hirabayashi and S Hochi. - intechopen.com
http://cdn.intechweb.org/pdfs/15668.pdf 

Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras.
A Isotani, H Hatayama, K Kaseda, M Ikawa, M Okabe*.
Genes to Cells 2011, 16 (4), 397–405.
*2i: CHIR99021 and PD0325901, from Axon Medchem

Loss of Dnd1 facilitates the cultivation of genital ridge-derived rat embryonic germ cells.
E Northrup, R Eisenblätter, S Glage, C Rudolph, M Dorsch, B Schlegelberger, HJ Hedrich, NH Zschemisch.
Exp. Cell Res. 2011, 317 (13), 1885–1894. 

METHOD FOR PRODUCING HETEROGENOUS EMBRYONIC CHIMERIC ANIMAL USING A STEM CELL.
US Patent Application 20110283374. (*2i: CHIR99021 and PD0325901, from Axon Medchem) 

PKC‐dependent endocytosis of the Helicobacter pylori vacuolating cytotoxin in primary T lymphocytes. 
X Sewald, L Jiménez-Soto, R Haas.
Cell. Microbiol. 2011, 13 (3), 482–496. (* CHIR99021 and BX795, from Axon Medchem) 

Wnt/{beta}-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma.
TL Biechele, RM Kulikauskas, RA Toroni, OM Lucero, RD Swift, RG James, NC Robin, DW Dawson, RT Moon, AJ Chien. 
Science Signal. 2012, 5 (206), ra3. 

Induced pluripotent stem cells from hair follicles as a cellular model for neurodevelopmental disorders.
I Petit, N Salman Kesner, R Karry, O Robicsek, E Aberdam, FJ Müller, D Aberdam, D Ben-Shachar.
Stem Cell Res. 2012, 8 (1), 134–140. 

Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells.
Y Kunisada, N Tsubooka-Yamazoe, M Shoji, M Hosoya.
Stem Cell Res. 2012, 8 (2), 274–284. 

RTEL1 contributes to DNA replication, repair and telomere maintenance.
EJ Uringa, K Lisaingo, HA Pickett… and PM Lansdorp*
Mol. Biol. Cell. 2012, mbc.E12-03-0179. 

Effect of Small Molecule Supplements during In Vitro Culture of Mouse Zygotes and Parthenogenetic Embryos on Hypoblast Formation and Stem Cell Derivation.
K. Versieren, M. Van der Jeught, T. O’Leary, G. Duggal, J. Gerris, S. Chuva de Sousa Lopes, B. Heindryckx and P. De Sutter.
STEM CELL REVIEWS AND REPORTS 2012, DOI: 10.1007/s12015-012-9382-7
*2i: CHIR99021 and PD0325901, from Axon Medchem

Lmx1a Allows Context‐Specific Isolation of Progenitors of GABAergic or Dopaminergic Neurons During Neural Differentiation of Embryonic Stem Cells.
CM Nefzger, CT Su, SA Fabb, BJ Hartley, SJ. Beh, WR Zeng, JM Haynes, CW Pouton.
STEM CELLS 2012, 30 (7), 1349–1361. 

Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo.
野田哲平 - 甲第 2470 号, 2012 - qir.kyushu-u.ac.jp
URL:  http://hdl.handle.net/2324/21729
http://www.med.kyushu-u.ac.jp/ / http://www.elsevier.com/locate/issn/00121606 

Ability of tetraploid rat blastocysts to support fetal development after complementation with embryonic stem cells.
M Hirabayashi, C Tamura, M Sanbo, T Goto, M Kato-Itoh, T Kobayashi, H Nakauchi, S Hochi.
Mol. Repro. & Develop. 2012, 79 (6), 402-412. 

Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo.
T Noda, S Oki, K Kitajima, T Harada, S Komuneb, C Meno.
Devel. Biol. 2012, 362 (1), 83-93. 

TRIM6 interacts with c-Myc and maintains pluripotency of mouse embryonal stem cells.
T Sato, F Okumura, T Ariga, S Hatakeyama*.
J. Cell Sci. 2012, 125, 1544-1555. 

A Chemical Genomics Screen to Discover Genes That Modulate Neural Stem Cell Differentiation.
KJ Kim, J Wang, X Xu, S Wu, W Zhang, Z Qin, F Wu, A Liu, Y Zhao, H Fang, M Zhu, J Zhao, Z Zhong.
J. Biomol. Screen. 2012, 17(2), 129-139.  doi: 10.1177/1087057111422379 
Read more: http://jbx.sagepub.com/content/17/2/129.short 

Modulation of Neuronal Pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.
D Schvartz, Y Couté, Y Brunner, CB Wollheim and JC Sanchez*
Mol. & Cell. Proteomics 2012, 11, 244-254.  mcp.M112.018051.
Read more: http://www.mcponline.org/content/11/8/244.short 

In vitro expansion and functional recovery of mature hepatocytes from mouse adult liver.
H Ito, A Kamiya*, K Ito, A Yanagida, K Okada, H Nakauchi*
Liver International 2012, 32 (4), 592-601. (*2i: CHIR99021 and PD0325901, from Axon Medchem) 

Germline Transmission of a Novel Rat Embryonic Stem Cell Line Derived From Transgenic Rats.
H Men, BA Bauer, and EC Bryda. 
Stem Cells and Development 2012, 21(14), 2606-2612. doi:10.1089/scd.2012.0040.
Read more: http://online.liebertpub.com/doi/abs/10.1089/scd.2012.0040 

Identification of Rat Rosa26 Locus Enables Generation of Knock-in Rat Lines Ubiquitously Expressing tdTomato.
T Kobayashi, M Kato-Itoh, T Yamaguchi, C Tamura, M Sanbo, M Hirabayashi, and H Nakauchi. 
Stem Cells and Development 2012, 21(16): 2981-2986. doi:10.1089/scd.2012.0065.
Read more: http://online.liebertpub.com/doi/abs/10.1089/scd.2012.0065
*2i: CHIR99021 and PD0325901, from Axon Medchem

GSK-3β activity in the hippocampus is required for memory retrieval.
JG Hong, DH Kim, CH Lee, SJ Park, JM Kim, M Cai, DS Jang, JH Ryu.
Neurobiol. Learn. Memory 2012, 98 (2) 122-129.
Read more: http://www.sciencedirect.com/science/article/pii/S1074742712000937 

Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.
N Schmidt, S Basu, S Sladecek, S Gatti, J van Haren, S Treves, J Pielage, N Galjart, and HR Brenner. 
J Cell Biol, 2012, July, ahead of print.  doi: 10.1083/jcb.201111130. 

Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. 
LTY Cho, SE Wamaitha, IJ Tsai, J Artus, RI Sherwood, RA Pedersen, AK Hadjantonakis, KK Niakan*
Development 2012, 139, 2866-2877. 

A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions.
I Minami, K Yamada, TG Otsuji, T Yamamoto, Y Shen, S Otsuka, S Kadota, N Morone, M Barve, Y Asai, T Tenkova-Heuser, JE Heuser, M Uesugi, K Aiba, N Nakatsuji.
Cell Reports 2012, 2(5), 1448–1460. [online]
Read more: http://www.cell.com/cell-reports/fulltext/S2211-1247(12)00319-1?switch=standard 

N-myc Downstream Regulated Gene 1 (NDRG1) Promotes Metastasis of Human Scirrhous Gastric Cancer Cells through Epithelial Mesenchymal Transition.
H Ureshino, Y Murakami, K Watari, H Izumi, A Kawahara, M Kage, T Arao, K Nishio, K Yanagihara, H Kinoshita, M Kuwano, M Ono.
PLoS ONE 2012, 7(7): e41312. doi:10.1371/journal.pone.0041312
Read more: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0041312 

Insulin Increases Epiblast Cell Number of In Vitro Cultured Mouse Embryos via the PI3K/GSK3/p53 Pathway.
JM Campbell, MB Nottle, I Vassiliev, M Mitchell, and M Lane. 
Stem Cells and Development. 2012, 21(13): 2430-2441. doi:10.1089/scd.2011.0598. 
Read more: http://online.liebertpub.com/doi/abs/10.1089/scd.2011.0598 

Small Molecule-Assisted, Line-Independent Maintenance of Human Pluripotent Stem Cells in Defined Conditions. 
S Frank, M Zhang, HR Schöler, B Greber.
PLoS ONE 2012, 7(7): e41958. doi:10.1371/journal.pone.0041958
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0041958 

Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells.
K Kemper, PR Prasetyanti, W De Lau, H Rodermond, H Clevers, JP Medema.
Stem Cell. 2012, 30(11), 2378–2386.
http://onlinelibrary.wiley.com/doi/10.1002/stem.1233/abstract 

Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states
LTY Cho, SE Wamaitha, IJ Tsai, J Artus, RI Sherwood, RA Pedersen, AK Hadjantonakis, KK Niakan.
Development 2012, 139, 2866-2877. doi: 10.1242/dev.078519
http://dev.biologists.org/content/139/16/2866.short 

A retrospective analysis of germline competence in rat embryonic stem cell lines.
M Hirabayashi, C Tamura, M Sanbo, M Kato-Itoh, T Kobayashi, H Nakauchi, S Hochi.
Transgenic Res. 2012, 22(2), 411-416.
http://link.springer.com/article/10.1007%2Fs11248-012-9638-7?LI=true 

Two distinct knockout approaches highlight a critical role for p53 in rat development.
M Kawamata & T Ochiya. - nature.com - 
Scientific Reports 2012, 2, 945. doi:10.1038/srep00945
http://www.nature.com/srep/2012/121210/srep00945/full/srep00945.html 

Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
A Kirkeby, J Nelander, M Parmar
Front Cell Neurosci. 2012, 6, 64. doi: 10.3389/fncel.2012.00064 PMCID: PMC3539732
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539732/ 

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions.
A Kirkeby, S Grealish, DA Wolf, J Nelander, J Wood, M Lundblad, O Lindvall, M Parmar.
Cell Reports 2012, 1 (6), 703–714.
Read more: http://www.sciencedirect.com/science/article/pii/S2211124712001222 

METHOD FOR CONSTRUCTING CHIMERIC RAT USING RAT EMBRYONIC STEM CELLS
T Ochiya, M Kawamata.
United States Patent Application 20120272349
http://www.freepatentsonline.com/y2013/0022986.html 

METHOD FOR CONSTRUCTING CHIMERIC RAT USING RAT EMBRYONIC STEM CELLS. 
T Ochiya, M Kawamata - European Patent Application EP2508595, issuedOctober 10, 2012. 

INDUCED HEPATIC STEM CELL AND PROCESS FOR PRODUCTION THEREOF, AND APPLICATIONS OF THE CELL.
T Ishikawa, K Hagiwara, and T Ochiya.
European Patent EP 2532741, issuedDecember 12, 2012. 

Telomere Elongation During Morula-to-Blastocyst Transition in Cloned Porcine Embryos.
TQ Dang-Nguyen, S Haraguchi, S Akagi, T Somfai, M Kaneda, S Watanabe, K Kikuchi, A Tajima, T Nagai. 
Cell. Reprogram. 2012, 14(6), 514-519. doi:10.1089/cell.2012.0045.
http://online.liebertpub.com/doi/abs/10.1089/cell.2012.0045 

The Combination of Inhibitors of FGF/MEK/Erk and GSK3β Signaling Increases the Number of OCT3/4- and NANOG-Positive Cells in the Human Inner Cell Mass, But Does Not Improve Stem Cell Derivation.
M vd Jeught, T O'Leary, S Ghimire, S Lierman, G Duggal, K Versieren, D Deforce, SC de Sousa Lopes, B Heindryckx, P De Sutter. 
Stem Cells and Development. 2013, 22(2), 296-306. doi:10.1089/scd.2012.0256.
http://online.liebertpub.com/doi/abs/10.1089/scd.2012.0256 

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.
AA Mansour, O Gafni, L Weinberger, A Zviran, M Ayyash, Y Rais, Vl Krupalnik, M Zerbib, D Amann-Zalcenstein, I Maza, S Geula, S Viukov, L Holtzman, A Pribluda, E Canaani, S Horn-Saban, I Amit, N Novershtern & JH Hanna.
Nature 2012, 488, 409–413. doi:10.1038/nature11272
http://www.nature.com/nature/journal/v488/n7411/abs/nature11272.html 

Implication of DNA Demethylation and Bivalent Histone Modification for Selective Gene Regulation in Mouse Primordial Germ Cells.
K Mochizuki, M Tachibana, M Saitou, Y Tokitake, Y Matsui.
PLoS ONE 2012, 7(9): e46036. doi:10.1371/journal.pone.0046036
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046036 

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice.
P Serup, C Gustavsen, T Klein, LA Potter, R Lin, N Mullapudi, E Wandzioch, A Hines, A Davis, C Bruun, N Engberg, DR Petersen, JML Peterslund, RJ MacDonald, A Grapin-Botton, MA Magnuson and KS Zaret.
Dis. Model. Mech. 2012, 5(6), 956-966. doi: 10.1242/dmm.009696
Read more:http://dmm.biologists.org/content/5/6/956.short

Human and mouse induced pluripotent stem cells are differentially reprogrammed in response to kinase inhibitors. 
K Hirano, S Nagata, S Yamaguchi, M Nakagawa, K Okita, H Kotera, J Ainscough and T Tada. 
Stem Cells and Development. 2012, 21(8), 1287-1298. doi:10.1089/scd.2011.0283.
Read more: http://www.ncbi.nlm.nih.gov/pubmed/21882976 

Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development. 
K Okada, A Kamiya, K Ito, A Yanagida, H Ito, H Kondou, H Nishina, and H Nakauchi. 
Stem Cells and Development. 2012, 21(7), 1124-1133. doi:10.1089/scd.2011.0229.
Read more: http://online.liebertpub.com/doi/abs/10.1089/scd.2011.0229
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) were procured from Axon Medchem.

* Many investigators in stem cell research often use CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) together as 2i (Axon 2128).

See publications used PD 0325901 from Axon Medchem

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