CHIR 99021 - CT 99021

Based on 3890 reference(s) in Google Scholar 10 10 3890

Axon 1386

CAS [252917-06-9]

MF C22H18Cl2N8
MW 465.34

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

CHIR 99021

Description

Very potent and specific glycogen synthase kinase GSK-3 inhibitor; highly recommended tool. * CHIR 99021 and PD 0325901 (Axon 1408) are often used together as 2i in stem cell research (Axon 2128).

CHIR 99021 is also available as the water soluble HCl salt (Axon 2435)

*Promotion: CHIR 99021 is also part of Inhibitor Set(s):

Axon 2128	Axon 2129	Axon 2130	Axon 5005
Axon 5006	Axon 5007	Axon 5010

Prime Source Information:
CHIR 99021 from Axon Medchem has been procured by many labs as drug standard for generating reliable and reproducible biological data, evidenced by many recent publications. It is pure not only chemically but also biologically.

C Tong et al. Generating gene knockout rats by homologous recombination in embryonic stem cells. Nature Protocols 2011, 6, 827–844.

M Kawamata and T Ochiya. Generation of genetically modified rats from embryonic stem cells. PNAS 2010, 107(32), 14223-14228.

MY Chang et al. Direct Reprogramming of Rat Neural Precursor Cells and Fibroblasts into Pluripotent Stem Cells. PLoS One. 2010, 5(3), e9838.

IM Aparicio et al. Identification and regulation of glycogen synthase kinase-3 during bovine embryo development. Reproduction 2010, 140, 83-92.

B Zimmer et al. Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. Cell Death and Differentiation. 2011, 18, 383–395.

Q.L.Ying et al. The ground state of embryonic stem cell self-renewal. Nature. 2008, 453, 519-523.

J. Bain et al. The selectivity of protein kinase inhibitors: a further update. Biochem. J. 2007, 408, 297-315.

D.B. Ring et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003, 52, 588-595.

A.S. Wagman et al. Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes. Curr. Pharm. Des. 2004, 10, 1105-1137.

List of publications using CHIR 99021 (Axon 1386) purchased from Axon Medchem

Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 Wnt-β-Catenin PI3K-Akt-mTOR EC 2.7.11.26 Recent Price Changes

GSK-3 inhibitor

Chemical name

6-{2-[4-(2,4-Dichloro-phenyl)-5-(5-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile

Parent CAS No.

[252917-06-9]

Order

Size	Unit Price	Stock
2 mg	€70.00	In Stock
5 mg	€95.00	In Stock
25 mg	€345.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€140.00	In Stock
2 x 25 mg	€540.00	In Stock

Need more? Bulk Inquiry

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1766	ICG 001	Specific inhibitor of Wnt/β-catenin signaling pathway	€115.00
1909	A 1070722	Selective inhibitor of GSK-3	€95.00
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2084	SKL 2001	Wnt/β-catenin signaling pathway agonist or activator	€90.00
2120	Wnt agonist 1	Wnt/β-catenin signaling pathway agonist or activator	€90.00
2133	iCRT5	β-Catenin-responsive transcription (CRT) inhibitor	€80.00
2167	AR-A 014418	ATP-competitive GSK-3 inhibitor	€85.00
2171	AZD 1080	Selective inhibitor of GSK-3α and GSK-3β	€110.00
2194	AZD 2858 hydrochloride	Potent and highly selective Glycogen Synthase Kinase-3β inhibitor	€95.00
2287	Wnt-C59	Highly potent porcupine (Porcn) inhibitor	€75.00
2128	Stem Cell 2i inhibitor Set	Set of MEK inhibitor PD0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386)	€110.00
2129	Stem Cell 3i inhibitor Set	Set of FGFR inhibitor SU5402 (Axon 1667), MEK inhibitor PD184352 (Axon 1368) and GSK-3 inhibitor CHIR99021 (Axon 1386)	€155.00
2130	Stem Cell Alternative 2i inhibitor Set	Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386)	€110.00
5005	Stem Cell LSC inhibitor Set	Set of LDN 193189 HCl, SB 431542 and CHIR 99021, inhibitors of BMP, TGF-β, and GSK-3 resp.	€155.00
5006	Stem Cell CSD inhibitor Set	Set of CHIR 99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp.	€155.00
5007	Stem Cell 5i inhibitor Set	Set of five inhibitors for neural differentiation of human pluripotent stem cells.	€240.00
2435	CHIR 99021 dihydrochloride	GSK-3 inhibitor	€70.00
5010	Naive Stem Cell NHSM inhibitor Set	Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs	€275.00

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CHIR 99021 - CT 99021

Description

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CHIR 99021 - CT 99021

Description

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