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AR-A 014418
- Soluble in DMSO
- MF: C12H12N4O4S
- MW: 308.31
Description
AR-A 014418 is a specific ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3). It is used to block GSK-3-dependent phosphorylation events in cellular signaling and disease models.
GSK-3 regulates glycogen metabolism, Wnt/β-catenin signaling, tau phosphorylation, apoptosis and inflammatory responses. AR-A 014418 is relevant for probing GSK-3 function in neurodegeneration, metabolism and cell-fate regulation.
Key Features
- ATP-competitive GSK-3 inhibitor
- Blocks GSK-3-dependent phosphorylation events
- Useful canonical GSK-3 pharmacology tool
- Relevant to Wnt, tau and metabolic signaling
Applications
- GSK-3 kinase assays
- Wnt/β-catenin pathway research
- Tau phosphorylation studies
- Metabolic and neurodegenerative disease models
More Information
| Parent CAS No. | 487021-52-3 |
|---|---|
| Chemical Name | 1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea |
| SMILES | C1(CNC(=O)NC2=NC=C([N+]([O-])=O)S2)=CC=C(OC)C=C1 |
| MFCD | MFCD08277040 |
| InChi | InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17) |
| InChiKey | YAEMHJKFIIIULI-UHFFFAOYSA-N |
| CID | 448014 |
| Short Description | GSK-3 inhibitor |
References
- R Bhat et al. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J. Biol. Chem. 2003, 278(46), 45937-45945.
- TD Gould et al. AR-A 014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int. J. Neuropsychopharmacol. 2004, 7(4), 387-390.
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