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Bisindolylmaleimide I
- GF109203X
- Soluble in DMSO
- MF: C25H24N4O2
- MW: 412.48
Description
Bisindolylmaleimide I is a potent and selective inhibitor of protein kinase C with IC50 values of 20 nM, 17 nM, 16 nM and 20 nM for subtypes PKCα, PKCβ1, PKCβ2 and PKCγ, respectively. Bisindolylmaleimide I is also a potent GSK-3 inhibitor.
More Information
| Parent CAS No. | 133052-90-1 |
|---|---|
| Chemical Name | 3-(1-(3-(Dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| SMILES | C1(C2=CNC3C=CC=CC2=3)C(=O)NC(=O)C=1C1C2C=CC=CC=2N(CCCN(C)C)C=1 |
| MFCD | MFCD00236428 |
| InChi | InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| InChiKey | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
| CID | 2396 |
| Short Description | PKC inhibitor |
References
- D Toullec et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem. 1991 Aug 25;266(24):15771-81.
- I Hers et al. The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. FEBS Lett. 1999 Nov 5;460(3):433-6.
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