Bulk Inquiry
UNC0379 trifluoroacetate
- Parent CAS: 1620401-82-2
- Soluble in water, DMSO and EtOH
- MF: C23H35N5O2·2C2HF3O2
- MW: 6416
Description
Substrate competitive inhibitor of the H4K20 HMTase SETD8 (IC50 value 7.3 µM) with selectivity over 15 other methyltransferases including G9a and GLP. MOA studies revealed that UNC0379 is noncompetitive with the cofactor S-adenosyl-Lmethionine (SAM). The free base UNC0379 is available as Axon 2418.
More Information
| Parent CAS No. | 1620401-82-2 |
|---|---|
| Chemical Name | 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine trifluoroacetate |
| SMILES | N1=C2C(C=C(OC)C(OC)=C2)=C(NCCCCCN2CCCC2)N=C1N1CCCC1.O=C(C(F)(F)F)O |
| MFCD | MFCD28167817 |
| InChi | InChI=1S/C23H35N5O2.C2HF3O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27;3-2(4,5)1(6)7/h16-17H,3-15H2,1-2H3,(H,24,25,26);(H,6,7) |
| InChiKey | NRGGPYZTHNAVFM-UHFFFAOYSA-N |
| CID | 92044361 |
| Short Description | SETD8 HMTase inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1254 | Zebularine |
From $104.50 |
| 1590 | Decitabine |
From $93.50 |
| 1691 | RG 108 |
From $88.00 |
| 1692 | BIX 01294 trihydrochloride |
From $88.00 |
| 1789 | UNC0224 |
From $93.50 |
| 1840 | UNC0646 |
From $108.90 |
| 1841 | UNC0631 |
From $108.90 |
| 1889 | UNC0638 |
From $93.50 |
| 2140 | GSK 126 |
From $82.50 |
| 2210 | C 7280948 |
From $93.50 |
| 2211 | PRMT3 inhibitor 1 |
From $115.50 |
| 2223 | Lomeguatrib |
From $148.50 |
| 2227 | EPZ 6438 |
From $99.00 |
| 2418 | UNC 0379 |
From $137.50 |
