Bulk Inquiry
Lomeguatrib
- PaTrin 2
- Soluble in DMSO
- MF: C10H8BrN5OS
- MW: 326.17
Description
More Information
| Parent CAS No. | 192441-08-0 |
|---|---|
| Chemical Name | 6-((4-bromothiophen-2-yl)methoxy)-7H-purin-2-amine |
| SMILES | N1C2C(=NC(N)=NC=2OCC2SC=C(Br)C=2)N=C1 |
| MFCD | MFCD09837804 |
| InChi | InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16) |
| InChiKey | JUJPKFNFCWJBCX-UHFFFAOYSA-N |
| CID | 3025944 |
| Short Description | MGMT inhibitor |
References
- H.A. Tawbi et al. Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours. Br. J. Cancer. 2011, 105, 773-777.
- M. Clemons et al. O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. Br. J. Cancer. 2005, 93, 1152-1156.
- M. Turriziani et al. O6-(4-bromothenyl)guanine (PaTrin-2), a novel inhibitor of O6-alkylguanine DNA alkyl-transferase, increases the inhibitory activity of temozolomide against human acute leukaemia cells in vitro. Pharmacol. Res. 2006, 53, 317-323.
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