GSK3685032 hydrochloride
- Parent CAS: 2170140-50-6
- Optical Purity: 99% e.e.
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C22H24N6OS.HCl
- MW: 457
Description
GSK3685032 hydrochloride is a potent first-in-class DNMT1-selective inhibitor. Induces robust loss of DNA methylation, transcriptional activation and cancer cell growth inhibition in vitro. Displays a much-improved in vivo tolerability and greater DNA hypomethylation compared with decitabine, translating into superior tumor regression and survival mouse models of acute myeloid leukemia.
More Information
| Parent CAS No. | 2170140-50-6 |
|---|---|
| Chemical Name | (R)-2-(6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-ylthio)-2-phenylacetamide hydrochloride |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C=C([C@@H](SC2N=C(N3CCC(N)CC3)C(C#N)=C(CC)C=2C#N)C(=O)N)C=CC=1.Cl |&1:3,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H24N6OS.ClH/c1-2-16-17(12-23)21(28-10-8-15(25)9-11-28)27-22(18(16)13-24)30-19(20(26)29)14-6-4-3-5-7-14;/h3-7,15,19H,2,8-11,25H2,1H3,(H2,26,29);1H/t19-;/m1./s1 |
| InChiKey | ZUEYTIHBJLWKPV-FSRHSHDFSA-N |
| CID | 165436125 |
| Short Description | DNMT1 inhibitor |
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