Methyltransferases

Over the recent years, Axon Medchem has significantly expanded its product line in the field of oncology research tools. Among them, the DNA methyltransferase and histone methyltransferase inhibitors comprise a small, yet significant selection of this set of tools. In view of the recent focus in biology on epigenetics, and DNA methylation being the best-known epigenetic marker (see also section: Axon Ligands™ for Epigenetic Research), we aim to be up front with these products to serve researchers in their objective to develop new drugs for the treatment of cancers and study the mechanisms involved in gene expression[1].


[1] Epigenetics in Cancer. M. Esteller.N Engl J Med 2008; 358, 1148-1159

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Axon ID Name Description From price
2705 A-196 Potent and selective inhibitor of SUV4-20 €105.00
2863 AMI-1 Inhibitor of PRMT  Recently added €99.00
2635 BAY-598 Selective inhibitor of SMYD2 €110.00
2735 BCI-121 Inhibitor of SMYD3 €90.00
1692 BIX 01294 trihydrochloride HMTase inhibitor (G9a and G9a-like protein) €80.00
2210 C 7280948 Sulfone inhibitor of PRMT1 €85.00
2709 CMP5 Inhibitor of PRMT5 €95.00
1590 Decitabine DNA methyltransferase inhibitor €85.00
2701 EED226 Potent, selective and orally bioavailable PRC2 inhibitor €105.00
2831 EPZ 015666 Potent, selective and orally available inhibitor of PRMT5 €125.00
2227 EPZ 6438 Inhibitor of Histone Lysine Methyltransferase EZH2 €105.00
2140 GSK 126 Inhibitor of Histone Lysine Methyltransferase EZH2 €75.00
2710 HLCL65 hydrochloride Inhibitor of PRMT5 €105.00
2223 Lomeguatrib Potent, orally active inhibitor of MGMT €135.00
2853 Nolatrexed dihydrochloride Water soluble inhibitor of thymidylate synthase  Recently added €120.00

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