Methyltransferases

Over the recent years, Axon Medchem has significantly expanded its product line in the field of oncology research tools. Among them, the DNA methyltransferase and histone methyltransferase inhibitors comprise a small, yet significant selection of this set of tools. In view of the recent focus in biology on epigenetics, and DNA methylation being the best-known epigenetic marker (see also section: Axon Ligands™ for Epigenetic Research), we aim to be up front with these products to serve researchers in their objective to develop new drugs for the treatment of cancers and study the mechanisms involved in gene expression[1].


[1] Epigenetics in Cancer. M. Esteller.N Engl J Med 2008; 358, 1148-1159

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Axon ID Name Description From price
2705 A-196 Potent and selective inhibitor of SUV4-20 €105.00
2863 AMI-1 Inhibitor of PRMT €99.00
2635 BAY-598 Selective inhibitor of SMYD2 €110.00
2735 BCI-121 Inhibitor of SMYD3 €90.00
1692 BIX 01294 trihydrochloride HMTase inhibitor (G9a and G9a-like protein) €80.00
2210 C 7280948 Sulfone inhibitor of PRMT1 €85.00
3460 Capecitabine Oral prodrug of fluorouracil; TYMS inhibitor €50.00
2812 CM-272 First-in-class potent, selective and reversible inhibitor of G9a/DNMT €125.00
2709 CMP5 Inhibitor of PRMT5 €95.00
1590 Decitabine DNA methyltransferase inhibitor €85.00
2701 EED226 Potent, selective and orally bioavailable PRC2 inhibitor €90.00
3389 Entacapone Potent, peripherally acting, reversible COMT inhibitor €50.00
2831 EPZ 015666 Potent, selective and orally available inhibitor of PRMT5 €125.00
2227 EPZ 6438 Inhibitor of Histone Lysine Methyltransferase EZH2 €105.00
3462 Floxuridine TYMS inhibitor; Antimetabolite €50.00
2140 GSK 126 Inhibitor of Histone Lysine Methyltransferase EZH2 €75.00
3750 GSK3326595 Orally active, potent, selective, SAM uncompetitive, peptide competitive, slow binding inhibitor of protein arginine methyltransferase 5 (PRMT5)  Recently added Inquire
2710 HLCL65 hydrochloride Inhibitor of PRMT5 €105.00
2223 Lomeguatrib Potent, orally active inhibitor of MGMT €135.00
3681 MS023 dihydrochloride Potent, cell-active, and Type I selective PRMT inhibitor  Recently added €90.00
3469 MS1943 trifluoroacetate First-in-class EZH2 selective degrader; PROTAC €200.00
2853 Nolatrexed dihydrochloride Water soluble inhibitor of thymidylate synthase €120.00
3162 Pemetrexed disodium Inhibitor of DHFR/TS/GARFT; Antifolate antimetabolite €50.00
3695 PF-06821497 Inhibitor of Histone Lysine Methyltransferase EZH2  Recently added Inquire
3692 PF-06939999 SAM competitive PRMT5 inhibitor  Recently added Inquire
2211 PRMT3 inhibitor 1 Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) €105.00
1691 RG 108 DNA methyltransferase inhibitor €80.00
2625 SGC2085 Potent and selective CARM1 inhibitor (aka PRMT4) €120.00
2945 SGC707 First-in-class, potent, selective and cell-active allosteric inhibitor of PRMT3 €90.00
2347 SGI 1027 dihydrochloride Inhibitor of DNMT activity in colon cancer cell lines €110.00

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