Methyltransferases

Over the recent years, Axon Medchem has significantly expanded its product line in the field of oncology research tools. Among them, the DNA methyltransferase and histone methyltransferase inhibitors comprise a small, yet significant selection of this set of tools. In view of the recent focus in biology on epigenetics, and DNA methylation being the best-known epigenetic marker (see also section: Axon Ligands™ for Epigenetic Research), we aim to be up front with these products to serve researchers in their objective to develop new drugs for the treatment of cancers and study the mechanisms involved in gene expression[1].


[1] Epigenetics in Cancer. M. Esteller.N Engl J Med 2008; 358, 1148-1159

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Axon ID Name Description From price
3695 PF-06821497 Inhibitor of Histone Lysine Methyltransferase EZH2 €160.00
3798 PF-06855800 SAM-pocket-binding (SAM competitive) PRMT5 inhibitor Inquire
3692 PF-06939999 dihydrochloride SAM competitive PRMT5 inhibitor Inquire
2211 PRMT3 inhibitor 1 Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) €105.00
1691 RG 108 DNA methyltransferase inhibitor €80.00
2625 SGC2085 Potent and selective CARM1 inhibitor (aka PRMT4) €120.00
2945 SGC707 First-in-class, potent, selective and cell-active allosteric inhibitor of PRMT3 €90.00
2347 SGI 1027 dihydrochloride Inhibitor of DNMT activity in colon cancer cell lines €110.00
5008 Stem Cell RG-BIX inhibitor Set Set of RG 108 and BIX 01294 HCl, inhibitors of DNMT and HMTase, respectively €60.00
3587 STM2457 First-in-class, highly potent and selective catalytic METTL3 inhibitor €130.00
3993 Tolcapone Potent, selective, orally active and reversible COMT inhibitor €70.00
1789 UNC0224 Inhibitor of G9a HMTase €85.00
2418 UNC0379 Substrate competitive inhibitor of the H4K20 HMTase SETD8 €125.00
1841 UNC0631 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00
1889 UNC0638 Inhibitor of G9a (EHMT2)/GLP (EHMT1) €85.00
1840 UNC0646 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00
3591 UNC6934 Potent and selective chemical probe targeting NSD2-PWWP1 €120.00
3592 UNC7145 Negative control of UNC6934 as a chemical probe targeting NSD2-PWWP1 €90.00
3722 Valemetostat Inhibitor of Histone Lysine Methyltransferase EZH1/2 Inquire
1254 Zebularine DNA methyltransferase inhibitor €95.00

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