Methyltransferases
Over the recent years, Axon Medchem has significantly expanded its product line in the field of oncology research tools. Among them, the DNA methyltransferase and histone methyltransferase inhibitors comprise a small, yet significant selection of this set of tools. In view of the recent focus in biology on epigenetics, and DNA methylation being the best-known epigenetic marker (see also section: Axon Ligands™ for Epigenetic Research), we aim to be up front with these products to serve researchers in their objective to develop new drugs for the treatment of cancers and study the mechanisms involved in gene expression[1].
[1] Epigenetics in Cancer. M. Esteller.N Engl J Med 2008; 358, 1148-1159
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3162 | Pemetrexed disodium | Inhibitor of DHFR/TS/GARFT; Antifolate antimetabolite | €50.00 | |
| 3695 | PF-06821497 | Inhibitor of Histone Lysine Methyltransferase EZH2 | €160.00 | |
| 3798 | PF-06855800 | SAM-pocket-binding (SAM competitive) PRMT5 inhibitor | Inquire | |
| 3692 | PF-06939999 dihydrochloride | SAM competitive PRMT5 inhibitor | Inquire | |
| 2211 | PRMT3 inhibitor 1 | Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) | €105.00 | |
| 1691 | RG 108 | DNA methyltransferase inhibitor | €80.00 | |
| 2625 | SGC2085 | Potent and selective CARM1 inhibitor (aka PRMT4) | €120.00 | |
| 2945 | SGC707 | First-in-class, potent, selective and cell-active allosteric inhibitor of PRMT3 | €90.00 | |
| 2347 | SGI 1027 dihydrochloride | Inhibitor of DNMT activity in colon cancer cell lines | €110.00 | |
| 5008 | Stem Cell RG-BIX inhibitor Set | Set of RG 108 and BIX 01294 HCl, inhibitors of DNMT and HMTase, respectively | €60.00 | |
| 3587 | STM2457 | First-in-class, highly potent and selective catalytic METTL3 inhibitor | €130.00 | |
| 4279 | TAS-102 | TYMS inhibitor; Antimetabolite | Recently added | €90.00 |
| 3993 | Tolcapone | Potent, selective, orally active and reversible COMT inhibitor | €70.00 | |
| 1789 | UNC0224 | Inhibitor of G9a HMTase | €85.00 | |
| 2418 | UNC0379 | Substrate competitive inhibitor of the H4K20 HMTase SETD8 | €125.00 | |
| 1841 | UNC0631 | Inhibitor of G9a/GLP Histone Lysine Methyltransferase | €99.00 | |
| 1889 | UNC0638 | Inhibitor of G9a (EHMT2)/GLP (EHMT1) | €85.00 | |
| 1840 | UNC0646 | Inhibitor of G9a/GLP Histone Lysine Methyltransferase | €99.00 | |
| 4105 | UNC3474 maleate | 53BP1 ligand | Recently added | €160.00 |
| 3591 | UNC6934 | Potent and selective chemical probe targeting NSD2-PWWP1 | €120.00 | |
| 3592 | UNC7145 | Negative control of UNC6934 as a chemical probe targeting NSD2-PWWP1 | €90.00 | |
| 4245 | UNC8732 | Highly potent second-generation NSD2 degrader | Recently added | €210.00 |
| 3722 | Valemetostat | Inhibitor of Histone Lysine Methyltransferase EZH1/2 | €160.00 | |
| 1254 | Zebularine | DNA methyltransferase inhibitor | €95.00 | |