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WAY-267464 dihydrochloride

Axon 2711
  • Parent CAS:  847375-16-0
Purity:  98%
  • Soluble in water and DMSO
  • MF:  C32H35N7O4.2HCl
  • MW:  654.59

Description

WAY-267464 dihydrochloride is a potent, nonpeptide agonist of the oxytocin receptor (OXTR), with a reported Ki of 58.4 nM at the human receptor. It activates OXTR-mediated signaling but does not fully reproduce the pharmacology of the peptide hormone oxytocin.

Receptor-profiling studies indicate that WAY-267464 has mixed oxytocin/vasopressin pharmacology and can act as a vasopressin V1A receptor antagonist. This activity is important when interpreting behavioral experiments, including social-recognition, anxiety-related, and stress-response studies. WAY-267464 is therefore most useful as a nonpeptide OXTR probe when OXTR and V1A receptor contributions are evaluated in parallel.

Key Features

  • Potent oxytocin receptor agonist
  • Ki: 58.4 nM at human OXTR
  • Also displays vasopressin V1A receptor antagonist activity
  • Suitable for receptor and behavioral pharmacology

Applications

  • Oxytocin receptor signaling
  • Oxytocin and vasopressin receptor selectivity
  • Social-recognition and social-behavior studies
  • Anxiety and stress-response research
  • Nonpeptide GPCR agonist pharmacology

More Information

Certificate of Analysis (B2)
Material Safety Data Sheet (B2)

Certificate of Analysis

B1

Material Safety Data Sheet

B1
Parent CAS No. 847375-16-0
Chemical Name 4-(3,5-Dihydroxybenzyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzyl)piperazine-1-carboxamide dihydrochloride
SMILES C1C(C)=C(CNC(=O)N2CCN(CC3C=C(O)C=C(O)C=3)CC2)C=CC=1C(=O)N1CC2C=NN(C)C=2NC2C=CC=CC1=2.Cl.Cl
MFCD N.A.
InChi InChI=1S/C32H35N7O4.2ClH/c1-21-13-23(31(42)39-20-25-18-34-36(2)30(25)35-28-5-3-4-6-29(28)39)7-8-24(21)17-33-32(43)38-11-9-37(10-12-38)19-22-14-26(40)16-27(41)15-22;;/h3-8,13-16,18,35,40-41H,9-12,17,19-20H2,1-2H3,(H,33,43);2*1H
InChiKey OTFWXMFLPMUDFP-UHFFFAOYSA-N
CID 136271320
Short Description OTR agonist

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