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EPZ 015666
- GSK 3235025
- Optical Purity: 0.99
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C20H25N5O3
- MW: 383.44
Description
EPZ 015666 (GSK 3235025) is a potent, selective and orally available inhibitor of PRMT5 (IC50 value of 22 nM). EPZ 015666 exhibits antiproliferative effects in both in vitro and in vivo models of MCL.
More Information
| Parent CAS No. | 1616391-65-1 |
|---|---|
| Chemical Name | (S)-N-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide |
| SMILES | C1(NC2COC2)C=C(C(=O)NC[C@H](O)CN2CC3C=CC=CC=3CC2)N=CN=1 |&1:12,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1 |
| InChiKey | ZKXZLIFRWWKZRY-KRWDZBQOSA-N |
| CID | 90241673 |
| Short Description | PRMT5 inhibitor |
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