JNJ-64619178 dihydrochloride
- Onametostat dihydrochloride
- Parent CAS: 2086772-26-9
- Optical Purity: 99% d.e.
- Soluble in water and DMSO
- MF: C22H23BrN6O2.2HCl
- MW: 556.28
Description
JNJ-64619178 is a SAM-pocket binding (SAM Competitive) PRMT5 inhibitor with high selectivity and potency (PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions. Demonstrates tumor regression in a biomarker-driven human small cell lung cancer xenograft model (NCI-H1048) and prolongs tumor growth inhibition after dosing cessation.
More Information
| Parent CAS No. | 2086772-26-9 |
|---|---|
| Chemical Name | (1S,2R,3S,5R)-3-(2-(2-amino-3-bromoquinolin-8-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol dihydrochloride |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | [C@@H]1(O)[C@H](O)[C@@H](CCC2C3N=C(N)C(Br)=CC=3C=CC=2)C[C@H]1N1C=CC2C(N)=NC=NC1=2.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-2-11(17(12)28-21(15)25)4-5-13-9-16(19(31)18(13)30)29-7-6-14-20(24)26-10-27-22(14)29/h1-3,6-8,10,13,16,18-19,30-31H,4-5,9H2,(H2,25,28)(H2,24,26,27)/t13-,16+,18+,19-/m0/s1 |
| InChiKey | HFODRHATXGREOI-QVSURHGTSA-N |
| CID | 165436124 |
| Short Description | PRMT5 inhibitor |
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