GSK3368715 hydrochloride
- GSK715 hydrochloride - EPZ019997 hydrochloride
- Parent CAS: 1629013-22-4
- Soluble in water and DMSO
- MF: C20H38N4O2.HCl
- MW: 403
Description
GSK3368715 is a first-in-class, orally active, potent and selective, SAM-Noncompetive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs) with IC50 in lower nM; alters exon usage and shows anti-tumor efficacy in multiple cancer models; synergizes with the PRMT5 inhibitor GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.
More Information
| Parent CAS No. | 1629013-22-4 |
|---|---|
| Chemical Name | N1-((3-(4,4-bis(ethoxymethyl)cyclohexyl)-1H-pyrazol-4-yl)methyl)-N1,N2-dimethylethane-1,2-diamine hydrochloride |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(=CNN=C1C1CCC(COCC)(COCC)CC1)CN(C)CCNC.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C20H38N4O2.ClH/c1-5-25-15-20(16-26-6-2)9-7-17(8-10-20)19-18(13-22-23-19)14-24(4)12-11-21-3;/h13,17,21H,5-12,14-16H2,1-4H3,(H,22,23);1H |
| InChiKey | WRVJUOWIQSTJPE-UHFFFAOYSA-N |
| CID | 90462879 |
| Short Description | PRMT inhibitor |
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