GSK3326595
- Pemrametostat - EPZ015938
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C24H32N6O3
- MW: 452.55
Description
GSK3326595 is an orally active, potent, selective, SAM uncompetitive, peptide competitive, slow binding inhibitor of protein arginine methyltransferase 5 (PRMT5)/MEP50 with a biochemical IC50 of 6 nM, and is >4,000-fold selective for PRMT5/MEP50 over any other enzyme when tested in a panel containing 20 other histone methyltransferases. Display potent antitumor activities in vitro and in vivo in animal models.
More Information
| Parent CAS No. | 1616392-22-3 |
|---|---|
| Chemical Name | (S)-6-(1-Acetylpiperidin-4-ylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1CC(NC2C=C(C(NC[C@H](O)CN3CC4C=CC=CC=4CC3)=O)N=CN=2)CCN1C(=O)C |&1:10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H32N6O3/c1-17(31)30-10-7-20(8-11-30)28-23-12-22(26-16-27-23)24(33)25-13-21(32)15-29-9-6-18-4-2-3-5-19(18)14-29/h2-5,12,16,20-21,32H,6-11,13-15H2,1H3,(H,25,33)(H,26,27,28)/t21-/m0/s1 |
| InChiKey | JLCCNYVTIWRPIZ-NRFANRHFSA-N |
| CID | 90241742 |
| Short Description | PRMT5 inhibitor |
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