PF-06939999 dihydrochloride
Axon 3692
- Parent CAS: 2159123-14-3
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C22H23F3N4O3.2HCl
- MW: 521.36
Description
PF-06939999 is an orally available and SAM competitive PRMT5 inhibitor binding to PRMT5-MEP-50 with high selectivity and affinity.
More Information
| Parent CAS No. | 2159123-14-3 |
|---|---|
| Chemical Name | (1S,2S,3S,5R)-3-(6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yloxy)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | N1CC2C(O[C@H]3C[C@@H](N4C=CC5C(C)=NC=NC4=5)[C@H](O)[C@@H]3O)=CC(C(F)F)=C(F)C=2CC1.Cl.Cl |&1:5,7,18,20,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H23F3N4O3.2ClH/c1-10-11-3-5-29(22(11)28-9-27-10)15-7-17(20(31)19(15)30)32-16-6-13(21(24)25)18(23)12-2-4-26-8-14(12)16;;/h3,5-6,9,15,17,19-21,26,30-31H,2,4,7-8H2,1H3;2*1H/t15-,17+,19+,20-;;/m1../s1 |
| InChiKey | UGQRIWIWRZAVBW-LACPWWQDSA-N |
| CID | 165436121 |
| Short Description | PRMT5 inhibitor |
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