PF-06855800
Axon 3798
CAS:
1989620-04-3
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C17H16ClFN4O4
- MW: 394.78
Description
PF-06855800 is a SAM-pocket-binding (SAM competitive) PRMT5 inhibitor with high selectivity and affinity (PRMT5-MEP-50, Ki < 0.1 nM) and demonstrates robust and efficacious antiproliferative activity in both in vitro and in vivo models.
More Information
| Parent CAS No. | 1989620-04-3 |
|---|---|
| Chemical Name | (2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(F)C=C([C@@H](O)[C@H]2O[C@@H](N3C=CC4C(N)=NC=NC3=4)[C@H](O)[C@@H]2O)C=CC=1Cl |&1:4,6,8,19,21,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H16ClFN4O4/c18-9-2-1-7(5-10(9)19)11(24)14-12(25)13(26)17(27-14)23-4-3-8-15(20)21-6-22-16(8)23/h1-6,11-14,17,24-26H,(H2,20,21,22)/t11-,12+,13-,14-,17-/m1/s1 |
| InChiKey | GTCYWLXMJRCJNE-QFRSUPTLSA-N |
| CID | 122497021 |
| Short Description | PRMT5 inhibitor |
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