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PNR-7-02

 - IBA-6
Axon 2965
CAS:  1633660-76-0
Purity:  98%
  • Soluble in DMSO
  • MF:  C24H16ClN3O2S
  • MW:  445.92

Description

PNR-7-02 is a potent inhibitor of human DNA polymerase η (hpol η) with an IC50 value of 8 μM and exhibited 5-10-fold specificity for hpol η over replicative pols.

More Information

Parent CAS No. 1633660-76-0
Chemical Name 5-((5-Chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
SMILES C1(Cl)C=C2C(/C=C3/C(=O)NC(=S)NC/3=O)=CN(CC3C=CC4C=CC=CC=4C=3)C2=CC=1
MFCD N.A.
InChi InChI=1S/C24H16ClN3O2S/c25-18-7-8-21-19(11-18)17(10-20-22(29)26-24(31)27-23(20)30)13-28(21)12-14-5-6-15-3-1-2-4-16(15)9-14/h1-11,13H,12H2,(H2,26,27,29,30,31)
InChiKey YNPDEEPROJUWCY-UHFFFAOYSA-N
CID 117677111
Short Description hpol η inhibitor

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