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RP-6685
- Soluble in DMSO and EtOH
- MF: C22H14F7N5O
- MW: 497.37
Description
RP-6685 is a potent, selective, and orally bioavailable Polθ inhibitor (IC50 value of 5.84 nM) that showed in vivo efficacy in an HCT116 BRCA2-/- mouse tumor xenograft model.
More Information
| Parent CAS No. | 2832047-80-8 |
|---|---|
| Chemical Name | N-(3-(6-Aminopyridazin-3-yl)prop-2-ynyl)-2-(3,5-bis(trifluoromethyl)pyridin-2-yl)-N-(4-fluorophenyl)acetamide |
| SMILES | C1(F)C=CC(N(CC#CC2C=CC(N)=NN=2)C(=O)CC2N=CC(C(F)(F)F)=CC=2C(F)(F)F)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H14F7N5O/c23-14-3-6-16(7-4-14)34(9-1-2-15-5-8-19(30)33-32-15)20(35)11-18-17(22(27,28)29)10-13(12-31-18)21(24,25)26/h3-8,10,12H,9,11H2,(H2,30,33) |
| InChiKey | LHFFKHVGAKIDNO-UHFFFAOYSA-N |
| CID | 165413021 |
| Short Description | Polθ inhibitor |
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