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Brivudine
- BVdU
- Optical Purity: Optically pure
- Soluble in water, DMSO and EtOH
- MF: C11H13BrN2O5
- MW: 333.14
Description
Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. Antiherpetic agent.
More Information
| Parent CAS No. | 69304-47-8 |
|---|---|
| Chemical Name | 5-((E)-2-Bromovinyl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SMILES | [C@@H]1(O)[C@@H](CO)O[C@@H](N2C=C(/C=C/Br)C(=O)NC2=O)C1 |&1:0,2,6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C11H13BrN2O5/c12-2-1-6-4-14(11(18)13-10(6)17)9-3-7(16)8(5-15)19-9/h1-2,4,7-9,15-16H,3,5H2,(H,13,17,18)/b2-1+/t7-,8+,9+/m0/s1 |
| InChiKey | ODZBBRURCPAEIQ-PIXDULNESA-N |
| CID | 446727 |
| Short Description | Polymerase inhibitor |
References
- T Kulikowski. Structure-activity relationships and conformational features of antiherpetic pyrimidine and purine nucleoside analogues. A review. Pharm World Sci. 1994 Apr 15;16(2):127-38.
- X Rabasseda. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71.
- S Chen et al. Discovery of BVDU as a promising Drug for autoimmune diseases Therapy by Dendritic-cell-based functional screening. Sci Rep. 2017 Mar 8;7:43820.
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