DNA

The primary role of DNA polymerases is to accurately and efficiently replicate the genome in order to ensure the maintenance of the genetic information and its faithful transmission through generations. This is not a simple task considering the size of the genome and its constant exposure to endogenous and environmental DNA damaging agents. Thus, a number of DNA repair pathways operate in cells to protect the integrity of the genome. In addition to their role in replication, DNA polymerases play a central role in most of these pathways. Given the multitude and the complexity of DNA transactions that depend on DNA polymerase activity, it is not surprising that cells in all organisms contain multiple highly specialized DNA polymerases, the majority of which have only recently been discovered. Five DNA polymerases are now recognized in Escherichia coli, 8 in Saccharomyces cerevisiae, and at least 15 in humans.[1]


[1] M. Garcia-Diaz et al. Multiple functions of DNA polymerases. CRC Crit Rev Plant Sci. 2007 Mar;26(2):105-122.

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3008 AOH1160 First-in-class, potent and orally available PCNA inhibitor  Recently added €120.00
3002 JH-RE-06 Specific and in vivo active REV1-REV7 interaction inhibitor €145.00
2965 PNR-7-02 Potent inhibitor of human DNA polymerase η €125.00

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