The primary role of DNA polymerases is to accurately and efficiently replicate the genome in order to ensure the maintenance of the genetic information and its faithful transmission through generations. This is not a simple task considering the size of the genome and its constant exposure to endogenous and environmental DNA damaging agents. Thus, a number of DNA repair pathways operate in cells to protect the integrity of the genome. In addition to their role in replication, DNA polymerases play a central role in most of these pathways. Given the multitude and the complexity of DNA transactions that depend on DNA polymerase activity, it is not surprising that cells in all organisms contain multiple highly specialized DNA polymerases, the majority of which have only recently been discovered. Five DNA polymerases are now recognized in Escherichia coli, 8 in Saccharomyces cerevisiae, and at least 15 in humans.[1]

[1] M. Garcia-Diaz et al. Multiple functions of DNA polymerases. CRC Crit Rev Plant Sci. 2007 Mar;26(2):105-122.

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3476 5-NIdR Potent inhibitor of translesion DNA synthesis (TLS) €120.00
3384 Acyclovir Highly selective inhibitor of herpes virus DNA polymerase €60.00
3008 AOH1160 First-in-class, potent and orally available PCNA inhibitor €120.00
4030 AOH1996 Orally available PCNA inhibitor €140.00
3664 Brivudine Inhibitor of herpes virus DNA polymerase €90.00
3239 Entecavir Competitive inhibitor of HBV viral polymerase €50.00
3241 Ganciclovir Inhibitor of CMV and herpes virus DNA polymerase €60.00
3002 JH-RE-06 Specific and in vivo active REV1-REV7 interaction inhibitor €145.00
3385 Penciclovir Highly selective inhibitor of herpes virus DNA polymerase €60.00
2965 PNR-7-02 Potent inhibitor of human DNA polymerase η €125.00
4003 RP-6685 Potent, selective, and orally bioavailable Polθ inhibitor €160.00
3506 Vidarabine Inhibitor of herpes virus DNA polymerase €50.00

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