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MLAF50
Axon 4103
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CAS:
1417653-96-3
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C15H12I2O4
- MW: 510.06
Description
MLAF50 is the first inhibitor of REV1 UBM2-ubiquitin interaction with a Kd value of 37 µM for REV1 UBM binding affinity. Moreover, MLAF50 inhibits chromatin localization of REV1 in cells after damaging DNA.
Key Features
- First-in-class REV1 UBM2-ubiquitin interaction inhibitor
- Kd: 37 μM for REV1 UBM2 binding affinity
- Disrupts REV1 recruitment following DNA damage
- Inhibits REV1 chromatin localization in cells
- Chemical probe for DNA damage tolerance research
Applications
- REV1 biology and translesion DNA synthesis research
- DNA damage tolerance pathway studies
- DNA repair and genome stability investigations
- Mutagenesis and replication stress research
- Cancer biology and DNA damage response studies
More Information
| Parent CAS No. | 1417653-96-3 |
|---|---|
| Chemical Name | 3-(3-(4-Hydroxyphenoxy)-2,4-diiodophenyl)propanoic acid |
| SMILES | C1(CCC(=O)O)C=CC(I)=C(OC2C=CC(O)=CC=2)C=1I |
| InChi | InChI=1S/C15H12I2O4/c16-12-7-1-9(2-8-13(19)20)14(17)15(12)21-11-5-3-10(18)4-6-11/h1,3-7,18H,2,8H2,(H,19,20) |
| InChiKey | RDLUIMMKEZXFEA-UHFFFAOYSA-N |
| CID | 117612246 |
| Short Description | REV1 UBM2-ubiquitin inhibitor |
MLAF50
MLAF 50
MLAF-50
REV1 UBM2-ubiquitin inhibitor
REV1 inhibitor
REV1 UBM2 inhibitor
ubiquitin binding motif inhibitor
UBM2 inhibitor
REV1
ubiquitin
translesion DNA synthesis
TLS
DNA damage tolerance
DNA repair
DNA damage response
DDR
genome stability
replication stress
mutagenesis
DNA lesion bypass
chromatin localization
protein-protein interaction inhibitor
DNA-RNA
CAS 1417653-96-3
Axon Medchem
Axon 4103
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