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JH-RE-06
Axon 3002
CAS:
1361227-90-8
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C20H16Cl3N3O4
- MW: 468.72
Description
JH-RE-06 is a compound disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS). Binding of JH-RE-06 induces REV1 dimerization, which blocks the REV1-REV7 interaction (IC50 value of 0.78 μM) and POL ζ recruitment. JH-RE-06 sensitizes tumors to cisplatin and reduces mutagenesis in vitro. Moreover, JH-RE-06 suppresses tumor progression in mice and prolongs animal survival.
More Information
| Parent CAS No. | 1361227-90-8 |
|---|---|
| Chemical Name | 8-Chloro-2-(2,4-dichlorophenylamino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one |
| SMILES | C1C([N+]([O-])=O)=C2C(=O)C(C(=O)CC(C)C)=C(NC3C(Cl)=CC(Cl)=CC=3)NC2=C(Cl)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H16Cl3N3O4/c1-9(2)7-15(27)17-19(28)16-14(26(29)30)6-4-11(22)18(16)25-20(17)24-13-5-3-10(21)8-12(13)23/h3-6,8-9H,7H2,1-2H3,(H2,24,25,28) |
| InChiKey | LRTXIQCBQIKIOH-UHFFFAOYSA-N |
| CID | 70691604 |
| Short Description | REV1-REV7 inhibitor |
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