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OG-L002 hydrochloride
- Parent CAS: 1357300-15-2
- Soluble in water and DMSO
- MF: C15H15NO.HCl
- MW: 261.75
Description
OG-L002 hydrochloride is a highly specific LSD1/KDM1A inhibitor with reported IC50 activity of approximately 0.02 µM. It inhibits lysine-specific demethylase 1 activity and modulates histone methylation-dependent transcriptional regulation.
LSD1 regulates H3K4 and H3K9 methylation marks involved in gene expression and viral chromatin control. OG-L002 is useful for studying epigenetic regulation of herpes simplex virus immediate-early gene expression, replication and latency reactivation.
Key Features
- Potent LSD1/KDM1A inhibitor
- Reported IC50: approximately 0.02 µM
- Modulates H3K4/H3K9 demethylation biology
- Represses HSV immediate-early gene expression in reported studies
Applications
- LSD1 enzyme assays
- Histone methylation studies
- HSV latency and reactivation models
- Epigenetic antiviral research
More Information
| Parent CAS No. | 1357300-15-2 |
|---|---|
| Chemical Name | 4'-((trans)-2-aminocyclopropyl)biphenyl-3-ol hydrochloride |
| MFCD | N.A. |
| Short Description | LSD1 inhibitor |
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