HIV

HIV

The human immunodeficiency viruses (HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans. HIV infects and destroys CD4 T cells, neutralizing antibodies have little effect on virus replication, and cytotoxic T lymphoctes (CTLs) limit HIV replication without stopping it. Over time, HIV infection causes acquired immunodeficiency syndrome (AIDS)[1,2]. The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs. Current antiviral treatments can reduce HIV-associated morbidity, prolong survival, and prevent HIV transmission. Combination antiretroviral therapy (cART) containing preferably three active drugs from two or more classes is required for durable virologic suppression.

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More About HIV

The human immunodeficiency viruses (HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans. HIV infects and destroys CD4 T cells, neutralizing antibodies have little effect on virus replication, and cytotoxic T lymphoctes (CTLs) limit HIV replication without stopping it. Over time, HIV infection causes acquired immunodeficiency syndrome (AIDS)[1,2]. The management of HIV/AIDS normally includes the use of  multiple antiretroviral drugs. Current antiviral treatments can reduce HIV-associated morbidity, prolong survival, and prevent HIV transmission. Combination antiretroviral therapy (cART) containing preferably three active drugs from two or more classes is required for durable virologic suppression[3].


[1] RA Weiss. How does HIV cause AIDS? Science. 1993 May 28;260(5112):1273-9.
[2] DC Douek et al. Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med. 2009;60:471-84.
[3] T Cihlar. Current status and prospects of HIV treatment. Curr Opin Virol. 2016 Jun;18:50-6.
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