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Emtricitabine
- (-)-FTC
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C8H10FN3O3S
- MW: 247.25
Description
Emtricitabine is a potent, orally bioavailable nucleoside reverse transcriptase inhibitor (NRTI) with an apparent IC50 value of 10 nM.
More Information
| Parent CAS No. | 143491-57-0 |
|---|---|
| Chemical Name | 4-Amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one |
| SMILES | S1[C@H](CO)O[C@H](N2C(=O)N=C(N)C(F)=C2)C1 |&1:1,5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1 |
| InChiKey | XQSPYNMVSIKCOC-NTSWFWBYSA-N |
| CID | 60877 |
| Short Description | NRT inhibitor |
References
- PA Furman et al. The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob Agents Chemother. 1992 Dec;36(12):2686-92.
- JE Frampton et al. Emtricitabine: a review of its use in the management of HIV infection. Drugs. 2005;65(10):1427-48.
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