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Stavudine
- 2’,3’-Didehydro-3’-deoxythymidine - d4T
- Optical Purity: Optically pure
- Soluble in water, DMSO and EtOH
- MF: C10H12N2O4
- MW: 224.21
Description
Stavudine is a nucleoside analogue which undergoes intracellular phosphorylation to its active metabolite, stavudine-5'-triphosphate. At clinically relevant concentrations, the active metabolite restricts HIV replication by inhibiting the inclusion of thymidine-5'-triphosphate into proviral DNA by HIV reverse transcriptase, and/or by causing DNA chain termination.
More Information
| Parent CAS No. | 3056-17-5 |
|---|---|
| Chemical Name | 1-((2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| SMILES | C1[C@@H](CO)O[C@@H](N2C=C(C)C(=O)NC2=O)C=1 |&1:1,5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1 |
| InChiKey | XNKLLVCARDGLGL-JGVFFNPUSA-N |
| CID | 18283 |
| Short Description | NRT inhibitor |
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