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Lamivudine
- 3TC - (-)-BCH189
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C8H11N3O3S
- MW: 229.26
Description
Lamivudine is a potent nucleoside reverse transcriptase inhibitor with activity against HIV and HBV.
More Information
| Parent CAS No. | 134678-17-4 |
|---|---|
| Chemical Name | 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one |
| SMILES | S1[C@H](CO)O[C@H](N2C(=O)N=C(N)C=C2)C1 |&1:1,5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1 |
| InChiKey | JTEGQNOMFQHVDC-NKWVEPMBSA-N |
| CID | 60825 |
| Short Description | NRT inhibitor |
References
- S Sun et al. Investigational drugs with dual activity against HBV and HIV (Review). Exp Ther Med. 2021 Jan;21(1):35.
- R van Leeuwen et al. The safety and pharmacokinetics of a reverse transcriptase inhibitor, 3TC, in patients with HIV infection: a phase I study. AIDS. 1992 Dec;6(12):1471-5.
- SL Doong et al. Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8495-9.
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