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PF 04981517
- CYP3cide - PF 4981517
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C26H32N8
- MW: 456.59
Description
PF 04981517 is a potent and selective CYP3A4 inhibitor with reported IC50 activity of 30 nM. It inactivates human CYP3A4 efficiently and time-dependently, making it valuable for mechanism-based inhibition studies.
CYP3A4 is a dominant drug-metabolizing enzyme involved in clearance and drug-drug interactions. PF 04981517, also known as CYP3cide, is useful for studying CYP3A4-dependent metabolism and discriminating CYP3A4 contribution in pharmacokinetic models.
Key Features
- Potent CYP3A4 inhibitor
- Reported IC50: 30 nM
- Time-dependent inactivation of human CYP3A4
- Useful tool for drug metabolism and DDI studies
Applications
- CYP3A4 enzyme assays
- Drug metabolism research
- Mechanism-based inhibition studies
- Pharmacokinetic interaction profiling
More Information
| Parent CAS No. | 1390637-82-7 |
|---|---|
| Chemical Name | (S)-1-methyl-3-(1-methyl-5-p-tolyl-1H-pyrazol-4-yl)-4-(3-(piperidin-1-yl)pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine |
| extra_info | . |
| SMILES | C1=NC(N2CC[C@H](N3CCCCC3)C2)=C2C(C3=C(C4=CC=C(C)C=C4)N(C)N=C3)=NN(C)C2=N1 |&1:6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/m0/s1 |
| InChiKey | WDWIMDKOXZZYHH-FQEVSTJZSA-N |
| CID | 71315139 |
| Short Description | CYP3A4 inhibitor |
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