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Tienilic Acid
- Ticrynafan
Axon 1564
CAS:
40180-04-9
Purity:
99%
- Soluble in DMSO
- MF: C13H8Cl2O4S
- MW: 331.17
Description
Tienilic acid was found to act as a suicide substrate at the cytochrome P450 enzymes involved in drug metabolism. It is a good mechanism based inhibitor of CYP2C9 and seems to inactivate it stoichiometrically
More Information
| Parent CAS No. | 40180-04-9 |
|---|---|
| Chemical Name | [2,3-Dichloro-4-(thiophene-2-carbonyl)-phenoxyl]-acetic acid |
| SMILES | C1(OCC(=O)O)C(Cl)=C(Cl)C(C(C2SC=CC=2)=O)=CC=1 |
| MFCD | MFCD00867339 |
| InChi | InChI=1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17) |
| InChiKey | AGHANLSBXUWXTB-UHFFFAOYSA-N |
| CID | 38409 |
| Short Description | CYP2C10 inhibitor |
References
- JW Manier et al. Hepatotoxicity associated with ticrynafen – a uricosuric diuretic. Am. J. Gastroenterol. 1982, 77(6), 401–4.
- P Jean et al. Oxidation of tienilic acid by human yeast-expressed cytochromes P450 2C8, 2C9, 2C18 and 2C19: Evidence that this drug is a mechanism-based inhibitor specific of cytochrome P450 2C9. Eur. J. Biochem. 1996, 241 797-804.
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