LOX
12/15-Lipoxygenase (12/15-LO(X); EC 1.13.11.31) is a non-heme, iron-containing enzyme that dioxygenates polyunsaturated fatty acids into bioactive lipid derivatives, more specifically: it can metabolize arachidonic acid to generate corresponding hydroxides such as 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-HETE. 12/15-LOX is widely expressed in the CNS, and has been demonstrated to be involved in the pathogenesis of various neurological diseases. 12/15-LOX exerts a regulatory role in Alzheimer’s disease, an inflammatory and neurodegenerative disease[1]. Additionally, human 12/15-LOX (aka 15-LOX-1) is also an attractive therapeutic target for its role in atherogenesis, diabetes, newborn periventricular leukomalacia, breast cancer and stroke[2].
[1] J. Xu et al. Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease. Cell Death Dis. 2013, 4, e569.
[2] G. Rai et al. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J. Med. Chem. 2014, 57, 4035-4048.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2989 | 15-LOX-1 inhibitor i472 | Inhibitor of 15-lipoxygenase-1 (15-LOX-1) | €170.00 | |
| 3176 | Diethylcarbamazine citrate | Filaricidal drug | €40.00 | |
| 2312 | ML 351 | Potent and selective inhibitor of 12/15-lipoxygenase (LOX) | €125.00 | |
| 2873 | ML 355 | Potent and selective inhibitor of 12-lipoxygenase (LOX) | €95.00 | |
| 2844 | ThioLox | Inhibitor of 15-lipoxygenase-1 (15-LOX-1) | €120.00 | |
| 3256 | Zileuton | Potent and orally active inhibitor of 5-lipoxygenase (5-LOX) | €50.00 | |