LOX

12/15-Lipoxygenase (12/15-LO(X); EC 1.13.11.31) is a non-heme, iron-containing enzyme that dioxygenates polyunsaturated fatty acids into bioactive lipid derivatives, more specifically: it can metabolize arachidonic acid to generate corresponding hydroxides such as 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-HETE. 12/15-LOX is widely expressed in the CNS, and has been demonstrated to be involved in the pathogenesis of various neurological diseases. 12/15-LOX exerts a regulatory role in Alzheimer’s disease, an inflammatory and neurodegenerative disease[1]. Additionally, human 12/15-LOX (aka 15-LOX-1) is also an attractive therapeutic target for its role in atherogenesis, diabetes, newborn periventricular leukomalacia, breast cancer and stroke[2].


[1] J. Xu et al. Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease. Cell Death Dis. 2013, 4, e569.
[2] G. Rai et al. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J. Med. Chem. 2014, 57, 4035-4048.

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Axon ID Name Description From price
2312 ML 351 Potent and selective inhibitor of 12/15-lipoxygenase (LOX) €125.00

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