LOX

LOX

12/15-Lipoxygenase (12/15-LO(X); EC 1.13.11.31) is a non-heme, iron-containing enzyme that dioxygenates polyunsaturated fatty acids into bioactive lipid derivatives, more specifically: it can metabolize arachidonic acid to generate corresponding hydroxides such as 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-HETE. 12/15-LOX is widely expressed in the CNS, and has been demonstrated to be involved in the pathogenesis of various neurological diseases. 12/15-LOX exerts a regulatory role in Alzheimer’s disease, an inflammatory and neurodegenerative disease. Additionally, human 12/15-LOX (aka 15-LOX-1) is also an attractive therapeutic target for its role in atherogenesis, diabetes, newborn periventricular leukomalacia, breast cancer and stroke.

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  • ML 351
    2312
    ML 351
    The price depends on the options chosen on the product page

    From $137.50

  • ThioLox
    2844
    ThioLox
    The price depends on the options chosen on the product page

    From $132.00

  • ML 355
    2873
    ML 355
    The price depends on the options chosen on the product page

    From $104.50

  • 15-LOX-1 inhibitor i472
    2989
    15-LOX-1 inhibitor i472
    The price depends on the options chosen on the product page

    From $187.00

  • Diethylcarbamazine citrate
    3176
    Diethylcarbamazine citrate
    The price depends on the options chosen on the product page

    From $55.00

  • Zileuton
    3256
    Zileuton
    The price depends on the options chosen on the product page

    From $55.00

6 Items

More About LOX

12/15-Lipoxygenase (12/15-LO(X); EC 1.13.11.31) is a non-heme, iron-containing enzyme that dioxygenates polyunsaturated fatty acids into bioactive lipid derivatives, more specifically: it can metabolize arachidonic acid to generate corresponding hydroxides such as 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-HETE. 12/15-LOX is widely expressed in the CNS, and has been demonstrated to be involved in the pathogenesis of various neurological diseases. 12/15-LOX exerts a regulatory role in Alzheimer’s disease, an inflammatory and neurodegenerative disease[1]. Additionally, human 12/15-LOX (aka 15-LOX-1) is also an attractive therapeutic target for its role in atherogenesis, diabetes, newborn periventricular leukomalacia, breast cancer and stroke[2].

[1] J. Xu et al. Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease. Cell Death Dis. 2013, 4, e569.
[2] G. Rai et al. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J. Med. Chem. 2014, 57, 4035-4048.

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