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ThioLox
- Thiophene A9
Axon 2844
CAS:
1202193-89-2
Purity:
99%
- Soluble in DMSO
- MF: C15H18N2OS
- MW: 274.38
Description
Inhibitor of 15-lipoxygenase-1 (15-LOX-1) with both anti-inflammatory and neuroprotective properties (IC50 value of 12 µM). Ex vivo biological evaluation in precision-cut lung slices (PCLS) showed inhibition of pro-inflammatory gene expression and in vitro studies on neuronal HT-22 cells showed a strong protection against glutamate toxicity for this 15-LOX-1 inhibitor.
*Sold in collaboration with RuG (University of Groningen)
More Information
| Parent CAS No. | 1202193-89-2 |
|---|---|
| Chemical Name | 2-Amino-N-butyl-5-phenylthiophene-3-carboxamide |
| extra_info | Sold in collaboration with RuG (University of Groningen) |
| SMILES | C1(C=CC=CC=1)C1=CC(C(=O)NCCCC)=C(N)S1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H18N2OS/c1-2-3-9-17-15(18)12-10-13(19-14(12)16)11-7-5-4-6-8-11/h4-8,10H,2-3,9,16H2,1H3,(H,17,18) |
| InChiKey | QWWMJRJCSZMXHZ-UHFFFAOYSA-N |
| CID | 53383638 |
| Short Description | Lipoxygenase inhibitor |
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