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Belzutifan
- PT2977 - MK-6482
Axon 3760
CAS:
1672668-24-4
- Optical Purity: 100% e.e.
- Soluble in DMSO
- MF: C17H12F3NO4S
- MW: 383.34
Description
Belzutifan is a second-generation potent, selective and orally active HIF-2α inhibitor with an IC50 value of 0.009 μM.
More Information
| Parent CAS No. | 1672668-24-4 |
|---|---|
| Chemical Name | 3-((1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yloxy)-5-fluorobenzonitrile |
| SMILES | C1(C#N)C=C(OC2C3[C@@H](F)[C@@H](F)[C@@H](O)C=3C(S(=O)(=O)C)=CC=2)C=C(F)C=1 |&1:8,10,12,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H12F3NO4S/c1-26(23,24)12-3-2-11(13-14(12)17(22)16(20)15(13)19)25-10-5-8(7-21)4-9(18)6-10/h2-6,15-17,22H,1H3/t15-,16-,17+/m1/s1 |
| InChiKey | LOMMPXLFBTZENJ-ZACQAIPSSA-N |
| CID | 117947097 |
| Short Description | HIF-2α inhibitor |
References
- R Xu et al. 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma. J Med Chem. 2019 Aug 8;62(15):6876-6893.
- M Abu-Remaileh et al. Targeting of HIF2-driven cachexia in kidney cancer. Nat Med. 2025 Nov 28.
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