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ML329
- CID 12387471
- Soluble in DMSO
- MF: C16H12N2O4S
- MW: 328.34
Description
ML329 is an inhibitor of the microphthalmia-associated transcription factor (MITF) pathway with an IC50 value of 1.2 μM for inhibition of TRPM-1 promoter activity. ML329 exhibits selective activity against MITF-dependent cells, with IC50 values of 0.1 μM and 0.7 μM in SK-MEL-5 and MALME-3M melanoma cell lines, respectively.
MITF is a lineage-specific transcription factor that functions as a master regulator of melanocyte development, pigmentation, survival, proliferation, and melanoma biology. Aberrant MITF signaling contributes to melanoma progression and therapeutic resistance. ML329 suppresses expression of the cell cycle regulator CDK2 and additionally exhibits CDK1 inhibitory activity (IC50 = 0.5 μM), making it a valuable chemical probe for studying MITF-dependent transcriptional programs, melanoma cell survival, and cell cycle regulation.
Key Features
- Inhibitor of the MITF molecular pathway
- IC50: 1.2 μM for TRPM-1 promoter activity
- Selective activity against MITF-dependent melanoma cells
- Reduces expression of the cell cycle regulator CDK2
- Exhibits CDK1 inhibitory activity (IC50: 0.5 μM)
Applications
- MITF signaling and transcription factor research
- Melanoma biology and target validation studies
- Cell cycle regulation investigations
- Cancer cell proliferation and survival research
- Transcriptional regulation and oncology studies
More Information
| Parent CAS No. | 19992-50-8 |
|---|---|
| Chemical Name | 4-(1,4-Dioxo-1,4-dihydronaphthalen-2-ylamino)benzenesulfonamide |
| SMILES | C1C=C2C(=O)C(NC3C=CC(S(=O)(=O)N)=CC=3)=CC(=O)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H12N2O4S/c17-23(21,22)11-7-5-10(6-8-11)18-14-9-15(19)12-3-1-2-4-13(12)16(14)20/h1-9,18H,(H2,17,21,22) |
| InChiKey | CSYFFQVEQXEIAB-UHFFFAOYSA-N |
| CID | 12387471 |
| Short Description | MITF inhibitor |
References
- PW Faloon et al. A Small Molecule Inhibitor of the MITF Molecular Pathway. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012.
- P Furet et al. Identification of cylin-dependent kinase 1 inhibitors of a new chemical type by structure-based design and database searching. J Comput Aided Mol Des. 2001 May;15(5):489-95.
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