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RBPJ inhibitor RIN1
- RIN1
Axon 3061
CAS:
2682114-39-0
Purity:
99%
- Soluble in DMSO
- MF: C17H14FN3O2
- MW: 311.31
Description
RBPJ inhibitor RIN1 is a potent, selective and first-in-class RBPJ transcription factor inhibitor. RIN1 inhibits RBPJ in both its activating NOTCH complexes and inhibitory SHARP complexes, disrupting RBPJ-dependent transcriptional regulation.
RBPJ, also known as CBF1, KBF2 or CSL, is the central DNA-binding transcription factor of canonical NOTCH signaling. RBPJ integrates activating and repressive protein complexes to regulate gene expression programs involved in cell fate, differentiation, proliferation and cancer biology. Consistent with disruption of NOTCH signaling, RIN1 inhibits proliferation of hematologic cancer cell lines and promotes skeletal muscle differentiation from C2C12 myoblasts.
Key Features
- Potent and selective RBPJ inhibitor
- First-in-class inhibitor of RBPJ transcriptional complexes
- Inhibits both NOTCH- and SHARP-associated RBPJ complexes
- Disrupts canonical NOTCH signaling
- Promotes skeletal muscle differentiation in C2C12 myoblasts
Applications
- RBPJ and NOTCH signaling research
- Transcription factor biology studies
- Hematologic cancer cell proliferation research
- Skeletal muscle differentiation studies
- Cell fate and developmental biology investigations
More Information
| Parent CAS No. | 2682114-39-0 |
|---|---|
| Chemical Name | 2-(2-Fluorophenoxy)-4-(1-methyl-1H-pyrazol-5-yl)benzamide |
| SMILES | C1C(C(N)=O)=C(OC2C(F)=CC=CC=2)C=C(C2N(C)N=CC=2)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H14FN3O2/c1-21-14(8-9-20-21)11-6-7-12(17(19)22)16(10-11)23-15-5-3-2-4-13(15)18/h2-10H,1H3,(H2,19,22) |
| InChiKey | MFSSHRCJKRDIOL-UHFFFAOYSA-N |
| CID | 146019721 |
| Short Description | RBPJ inhibitor |
RBPJ inhibitor RIN1
RIN1
RIN 1
RIN-1
RBPJ Inhibitor 1
RBPJ inhibitor
RBPJ transcription factor inhibitor
RBPJ
CBF1
KBF2
CSL
NOTCH signaling
canonical NOTCH signaling
SHARP complex
transcriptional regulation
hematologic cancer
cell proliferation
skeletal muscle differentiation
C2C12 myoblasts
cell fate
developmental biology
DNA-RNA
Transcription Factors
CAS 2682114-39-0
Axon Medchem
Axon 3061
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