The endothelial transcription factor ERG (another member of the ETS family of TFs) drives expression of vascular endothelial (VE)-cadherin and controls junctional integrity in angiogenesis. During mammalian embryogenesis, ERG is first expressed in endothelium and later in the kidney, urogenital tract and hematopoietic cells. The embryonic activation pattern of ERG is relevant to oncogenesis, since ERG transcription is specifically strongly upregulated in prostate cancer epithelial cells, and  in prostate endothelial cells as well. This may provide an example of oncogenic reactivation of an embryonic transcription factor[1].