Fork Head

Forkhead box (Fox) proteins are a family of evolutionarily conserved transcriptional regulators defined by a common DNA-binding domain (DBD) termed the forkhead box or winged helix domain[1]. The transcription factor FOXM1 (TF class 3.3.1) specifically binds to sequence-specific motifs on DNA (C/TAAACA) and activates proliferation- and differentiation-associated genes critical to mitotic spindle assembly, chromosome segregation and G2/M transition, with depletion leading to cell cycle arrest. Aberrant upregulation of FOXM1 has been shown to be a key driver of cancer progression and has been proposed as an initiating factor of oncogenesis. Furthermore, FOXM1 overexpression has been implicated in the development of chemotherapeutic resistance in human breast cancer[2].


[1] S.S. Myatt et al. The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer. 2007 Nov;7(11):847-59.
[2] M.V. Gormally et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165.

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2384 FDI 6 Inhibitor of the Forkhead box protein M1 (FOXM1) €99.00

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