Bulk Inquiry
AS 1842856
Axon 2839
CAS:
836620-48-5
Purity:
99%
- Soluble in DMSO
- MF: C18H22FN3O3
- MW: 347.38
Description
AS1842856 is a potent, selective and orally active inhibitor of the transcription factor FOXO1 with an IC50 value of 33 nM. It binds the active dephosphorylated form of FOXO1 and inhibits FOXO1-dependent transcription.
In hepatocyte models, AS1842856 reduces expression of gluconeogenic genes including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase, thereby decreasing glucose production. It is used to investigate FOXO1 function in hepatic metabolism, insulin signaling, immune-cell biology and cell-fate regulation.
Key Features
- Potent FOXO1 transcriptional inhibitor
- IC50: 33 nM
- Orally active
- Suppresses gluconeogenic gene expression
- Reduces hepatic glucose production
Applications
- FOXO1 transcription-factor research
- Insulin-signaling studies
- Hepatic gluconeogenesis assays
- Metabolic disease models
- Immune-cell and cell-fate research
More Information
| Parent CAS No. | 836620-48-5 |
|---|---|
| Chemical Name | 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| SMILES | N1(CC)C2=C(C(N)=C(F)C(NC3CCCCC3)=C2)C(=O)C(C(O)=O)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H22FN3O3/c1-2-22-9-11(18(24)25)17(23)14-13(22)8-12(15(19)16(14)20)21-10-6-4-3-5-7-10/h8-10,21H,2-7,20H2,1H3,(H,24,25) |
| InChiKey | MOMCHYGXXYBDCD-UHFFFAOYSA-N |
| CID | 72193864 |
| Short Description | FOXO1 inhibitor |
AS1842856
potent FOXO1 transcriptional inhibitor
AS 1842856
AS-1842856
FOXO1
Diabetes
FOXO1 transcriptional
Inhibitor
FOXO1 transcription-factor research
Insulin-signaling studies
Hepatic gluconeogenesis assays
Metabolic disease models
Immune-cell and cell-fate research
metabolism
receptor selectivity
signal transduction
transcriptional regulation
enzyme pharmacology
DNA-RNA
Transcription Factors
Forkhead box protein O1 transcription factor
CAS 836620-48-5
Axon Medchem
Axon 2839
Supplier
Vendor
Other Categories
Get a Quote for
Loading...