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7-Hydroxy-DPAT hydrobromide
- 7-OH-DPAT
Axon 1012
- Parent CAS: 74938-11-7
Purity:
98%
- Soluble in DMSO
- MF: C16H25NO.HBr
- MW: 328.29
Description
7-Hydroxy-DPAT hydrobromide is a dopamine D3 receptor agonist with reported preference for D3 over D2, D4 and D1 receptors. It is a standard tool for probing D3 receptor-mediated signaling and dopaminergic receptor subtype selectivity.
D3 receptors are implicated in reward, motivation and neuropsychiatric signaling. 7-Hydroxy-DPAT hydrobromide is useful in assays that require preferential activation of D3 receptors while comparing responses across dopamine receptor subtypes.
7-Hydroxy-DPAT hydrobromide is the racemate of the more active (R)-(+)-7-Hydroxy-DPAT hydrobromide (Axon 1013), and less active (S)-(-)-7-Hydroxy-DPAT hydrochloride (Axon 1014).
Key Features
- Preferential dopamine D3 receptor agonist
- Reported selectivity profile: D3 > D2 >> D4 and D1
- DPAT-related aminotetralin ligand
- Useful for receptor subtype selectivity studies
Applications
- D3 receptor pharmacology
- Dopamine receptor subtype profiling
- Reward and motivation pathway research
- GPCR signaling and functional assay development
More Information
| Parent CAS No. | 74938-11-7 |
|---|---|
| Chemical Name | 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol hydrobromide |
| SMILES | C1(O)C=C2CC(N(CCC)CCC)CCC2=CC=1.Br |
| MFCD | MFCD00153809 |
| InChi | InChI=1S/C16H25NO.BrH/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15;/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3;1H |
| InChiKey | ODNDMTWHRYECKX-UHFFFAOYSA-N |
| CID | 11957566 |
| Short Description | D3 agonist |
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