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U 99194 maleate

Axon 1069
  • Parent CAS:  82668-33-5
Purity:  99%
  • Soluble in water
  • MF:  C17H27NO2.C4H4O4
  • MW:  393.47

Description

U 99194 maleate is a selective and potent dopamine D3 receptor antagonist with approximately 30-fold preference for D3 over D2 receptors. It is a useful antagonist tool for distinguishing D3-mediated responses from D2 signaling.

D3 receptors are involved in mesolimbic dopamine signaling and reward-related neurobiology. U 99194 maleate enables pharmacological blockade of D3 receptors in receptor binding, functional and behavioral pathway studies.

Key Features

  • Selective dopamine D3 receptor antagonist
  • Approximately 30-fold preference for D3 versus D2 receptors
  • Useful for D3 versus D2 selectivity experiments
  • Enables pharmacological blockade of dopamine D3 receptor signaling

Applications

  • D3 receptor pharmacology
  • Dopamine receptor subtype discrimination
  • Reward pathway and neuropsychiatric research
  • GPCR antagonist assay development

More Information

Parent CAS No. 82668-33-5
Chemical Name (5,6-Dimethoxy-indan-2-yl)-dipropyl-amine maleate
SMILES C1(OC)C=C2CC(N(CCC)CCC)CC2=CC=1OC.C(/C(=O)O)=C/C(=O)O
MFCD MFCD01529985
InChi InChI=1S/C17H27NO2.C4H4O4/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15;5-3(6)1-2-4(7)8/h11-12,15H,5-10H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChiKey FSIQDESGRQTFNN-BTJKTKAUSA-N
CID 11957713
Short Description D3 antagonist

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