CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1023 Aminotetraline hydrochloride, N-Methyl-N-propyl-2- Dopamine agonist Inquire
1064 Aminotetraline hydrochloride, Prop-2-ynyl-2- Dopamine agonist Inquire
1381 Amisulpride D2 and D3 antagonist €45.00
1333 Amoxapine Tricyclic antidepressant; Potent reuptake inhibitor of norepinephrine (NRI) €50.00
1207 Amthamine dihydrobromide H2 agonist €75.00
2468 ANA 12 Selective TrkB antagonist with anxiolytic and antidepressant activity in mice €90.00
1321 Antalarmin hydrochloride CRF1 antagonist €105.00
2541 APD 597 Orally bioavailable selective GPR119 agonist €125.00
2380 APD 668 Potent and selective, orally active GPR119 agonist €125.00
1957 Apremilast PDE4 inhibitor €105.00
1486 Aprepitant Substance P antagonist (SPA); NK1 inhibitor €95.00
1572 AR 231453 Cannabinoid GPR119 agonist €85.00
2167 AR-A 014418 ATP-competitive GSK-3 inhibitor €85.00
2679 AR7 RARα antagonist that stimulates chaperone-mediated autophagy €90.00
1143 Aripiprazole Atypical antipsychotic €75.00

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