CNS

The human nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS, in turn, is divided into the brain and the spinal cord, which lie in the cranial cavity of the skull and the vertebral canal, respectively. The CNS and the PNS, acting in concert, integrate sensory information and control motor and cognitive functions. Based on its functions, the CNS can be divided into three main functional components: the sensory system, the motor system, and homeostatic and higher brain functions. Cell signaling throughout the CNS occurs by means of neurotransmitters or ions of various kinds interacting at membrane bound receptors and ion channels that, in turn, send the signal through second messenger systems to different compartments of the cell. Malfunctions of the CNS can cause numerous diseases and disorders such as Alzheimer's and Parkinson's disease, multiple sclerosis (MS), anxiety, schizophrenia, and many others. Although many of these failures of the CNS appear to be age related, some occur already in a very early stage of development of the organism, or may even be genetically inherited. The prevention and treatment of neurological disorders represents one of the most difficult and challenging goals of modern medical research.

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Axon ID Name Description From price
1747 AZ 12216052 Positive allosteric modulator (PAM) of mGluR8 €105.00
1644 Biphenyl-indanone A Positive allosteric modulator (PAM) of mGluR2 €85.00
2079 CMPDA Positive allosteric modulator of AMPA receptor €85.00
1431 CPPHA Positive allosteric modulator (PAM) of mGluR5 €95.00
2687 Farampator Second-generation ampakine that potentiates AMPA receptor function €99.00
1820 GS 39783 PAM of GABA-B Receptor €99.00
1121 NBI 34060 PAM of GABAA-α1 €95.00
1457 NS 11394 PAM of GABAA €115.00
1788 S 18986 Positive allosteric modulator of AMPA receptor €105.00
2463 TBPB Allosteric activator of the M1 acetylcholine receptor devoid of M2-M5 activity. €105.00
1988 VU 0029767 PAM of mAChR M1 that potentiates the agonistic effect of Ach €120.00
1483 VU 0152100 PAM of M4 mAChR €85.00
1786 VU 0238429 Selective PAM of M5 mAChR (CHRM5) €105.00
1703 VU 0357017 hydrochloride PAM of M1 mAChR €115.00
1894 VU 0357121 Positive allosteric modulator (PAM) of mGluR5 €85.00

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