Nicotinergic acetylcholine receptors are made up of 5 subunits, symmetrically arranged around a central pore (ion channel). It is considered the best-characterized LGIC and a prototypical structure for the class of 4TM receptors. nAChRs are found mainly in postsynaptic membranes of central nervous system synapses and of the neuromuscular endplate. The physiological signal to which nAChR responds is the neurotransmitter acetylcholine, but it is also activated by nicotine. The assembly of combinations of subunits (17 distinct subunits have been identified) results in a large number of different receptors with a high variety of functional diversity as a result. 5-HT3 differ from all other 5-HT (serotonin) receptors whose actions are mediated via G proteins. Their structure and function has placed them in the Cys-loop family of cationic ligand-gated ion channels. 5-HT3 receptors are located in both the peripheral (PNS) and central (CNS) nervous systems. In the CNS, 5-HT3 receptors may play roles in a variety of functions including emesis, cognition and anxiety, whereas in the PNS they play a role in a variety of sympathetic, parasympathetic and sensory functions (e.g. signaling in gastrointestinal tract, gut motility and peristalsis).
 Ligand-Gated Ion Channels. F. Hucho, C. Weise. Angew.Chem.Int.Ed. 2001, 40, 3100-3116.
 5-HT3 Receptors. A. J. Thompson, S. C. R. Lummis. Curr Pharm Des. 2006; 12(28): 3615–3630.
|Axon ID||Name||Description||From price|
|1097||Alosetron hydrochloride||5-HT3 antagonist||€85.00|
|2401||AT 1001||High affinity and selective α3β4 nAChR ligand with partial agonistic and antagonistic effects||€95.00|
|1096||Azasetron hydrochloride||5-HT3 antagonist||€90.00|
|2534||Azasetron hydrochloride, (+)-||5-HT3 antagonist||€135.00|
|2535||Azasetron hydrochloride, (-)-||5-HT3 antagonist||€135.00|
|1153||B-HT 920 dihydrochloride||D2 agonist, α2 adrenoceptor agonist; 5-HT3 antagonist||€75.00|
|1077||Epibatidine dihydrochloride, (+)-||Nicotinic acetylcholine receptor agonist||€155.00|
|1078||Epibatidine dihydrochloride, (-)-||Nicotinic acetylcholine receptor agonist||€155.00|
|1076||Epibatidine dihydrochloride, (±)-||Nicotinic acetylcholine receptor agonist||€95.00|
|2621||GAT107||allosteric agonist and PAM of α7 nAChR||Recently added||€105.00|
|1449||Granisetron hydrochloride||5-HT3 antagonist||€85.00|
|2109||PHA 543613 dihydrochloride||nAChR agonist (α7 sub-unit selective)||€85.00|
|1384||Varenicline dihydrochloride||Nicotinic acetylcholine receptor agonist||€95.00|
|2074||Varenicline tartrate||Selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist||€95.00|