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PHA 543613 dihydrochloride
- Parent CAS: 478149-53-0
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C15H17N3O2.2HCl
- MW: 344.24
Description
PHA 543613 dihydrochloride is a potent and selective α7 nicotinic acetylcholine receptor (α7 nAChR) agonist characterized by rapid brain penetration and high oral bioavailability. It is used to activate cholinergic α7 receptor signaling in CNS and immunomodulatory research.
The α7 nAChR is implicated in cognition, sensory processing, neuroinflammation and the cholinergic anti-inflammatory pathway. PHA 543613 is pharmacologically relevant for studying receptor activation in neuropsychiatric and inflammatory disease models.
Key Features
- Potent α7 nAChR agonist
- Selective activator of cholinergic α7 receptor signaling
- Rapid brain penetration reported
- High oral bioavailability in preclinical studies
Applications
- α7 nAChR pharmacology
- Cholinergic signaling studies
- Cognition and neuroinflammation research
- CNS drug-discovery assay development
More Information
| Parent CAS No. | 478149-53-0 |
|---|---|
| Chemical Name | (R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carboxamide dihydrochloride |
| extra_info | . |
| SMILES | Cl.Cl.C12OC=CC=1C=C(C(N[C@@H]1C3CCN(CC3)C1)=O)N=C2 |&1:11,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C15H17N3O2.2ClH/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18;;/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19);2*1H/t13-;;/m0../s1 |
| InChiKey | USJDQOUQSDDWPO-GXKRWWSZSA-N |
| CID | 11493927 |
| Short Description | nAChR agonist |
References
- DG Wishka et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive (...). J. Med. Chem. 2006, 49(14), 4425-4436.
- PR Krafft et al. PHA-543613 Preserves Blood–Brain Barrier Integrity After Intracerebral Hemorrhage in Mice. Stroke, 2013, 44(6), 1743-1747.
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