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GTS 21 dihydrochloride
- 3-(2,4-Dimethoxybenzylidene)-anabaseine dihydrochloride - DMXB - DMXB-A
Axon 2860
- Parent CAS: 148372-04-7
Purity:
100%
- Soluble in water and DMSO
- MF: C19H20N2O2.2HCl
- MW: 381.3
Description
Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist. At significantly higher concentrations GTS 21 behaves as an antagonist of α4β2 nAChRs and related type 3 5-HT receptors.
More Information
| Parent CAS No. | 148372-04-7 |
|---|---|
| Chemical Name | (E)-3-(3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine dihydrochloride |
| SMILES | C1C=CC(C2/C(=C/C3C(OC)=CC(OC)=CC=3)/CCCN=2)=CN=1.Cl.Cl |
| MFCD | MFCD00941364 |
| InChi | InChI=1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;; |
| InChiKey | BXKYFUGAAFLYJL-BXGYHSFXSA-N |
| CID | 6438361 |
| Short Description | α7 partial agonist |
References
- DS Woodruff-Pak et al. A nicotinic agonist (GTS-21), eyeblink classical conditioning, and nicotinic receptor binding in rabbit brain. Brain Res. 1994 May 9;645(1-2):309-17.
- W Kem et al. The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties. Mar Drugs. 2006 Apr; 4(3): 255–273.
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