nAChR
Nicotinergic acetylcholine receptors are made up of 5 subunits, symmetrically arranged around a central pore (ion channel). It is considered the best-characterized LGIC and a prototypical structure for the class of 4TM receptors. nAChRs are found mainly in postsynaptic membranes of central nervous system synapses and of the neuromuscular endplate. The physiological signal to which nAChR responds is the neurotransmitter acetylcholine, but it is also activated by nicotine. The assembly of combinations of subunits (17 distinct subunits have been identified) results in a large number of different receptors with a high variety of functional diversity as a result[1].
[1] Ligand-Gated Ion Channels. F. Hucho, C. Weise. Angew.Chem.Int.Ed. 2001, 40, 3100-3116.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1077 | (+)-Epibatidine dihydrochloride | Nicotinic acetylcholine receptor agonist | €155.00 | |
| 1078 | (-)-Epibatidine dihydrochloride | Nicotinic acetylcholine receptor agonist | €155.00 | |
| 1076 | (±)-Epibatidine dihydrochloride | Nicotinic acetylcholine receptor agonist | €95.00 | |
| 2694 | 4BP-TQS | Allosteric agonist of α7 nAChR | €110.00 | |
| 2401 | AT 1001 | High affinity and selective α3β4 nAChR ligand with partial agonistic and antagonistic effects | €95.00 | |
| 4113 | Encenicline hydrochloride | Selective and brain-penetrant α7 nicotinic acetylcholine receptor (nAChR) partial agonist | Recently added | €120.00 |
| 2621 | GAT107 | allosteric agonist and PAM of α7 nAChR | €110.00 | |
| 2860 | GTS 21 dihydrochloride | Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist | €90.00 | |
| 3286 | Penehyclidine hydrochloride | Anticholinergic drug | €130.00 | |
| 2109 | PHA 543613 dihydrochloride | nAChR agonist (α7 sub-unit selective) | €120.00 | |
| 2908 | PNU 282987 hydrochloride | nAChR agonist (α7 sub-unit selective) | €90.00 | |
| 3151 | QND7 | nAChR antagonist (α7 sub-unit selective) | €130.00 | |
| 1384 | Varenicline dihydrochloride | Nicotinic acetylcholine receptor agonist | €80.00 | |
| 2074 | Varenicline tartrate | Selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist | €90.00 | |