nAChR

Nicotinergic acetylcholine receptors are made up of 5 subunits, symmetrically arranged around a central pore (ion channel). It is considered the best-characterized LGIC and a prototypical structure for the class of 4TM receptors. nAChRs are found mainly in postsynaptic membranes of central nervous system synapses and of the neuromuscular endplate. The physiological signal to which nAChR responds is the neurotransmitter acetylcholine, but it is also activated by nicotine. The assembly of combinations of subunits (17 distinct subunits have been identified) results in a large number of different receptors with a high variety of functional diversity as a result[1]


[1] Ligand-Gated Ion Channels. F. Hucho, C. Weise. Angew.Chem.Int.Ed. 2001, 40, 3100-3116.

9 Item(s)

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Axon ID Name Description From price
2694 4BP-TQS Allosteric agonist of α7 nAChR €105.00
2401 AT 1001 High affinity and selective α3β4 nAChR ligand with partial agonistic and antagonistic effects €95.00
1077 Epibatidine dihydrochloride, (+)- Nicotinic acetylcholine receptor agonist €155.00
1078 Epibatidine dihydrochloride, (-)- Nicotinic acetylcholine receptor agonist €155.00
1076 Epibatidine dihydrochloride, (±)- Nicotinic acetylcholine receptor agonist €95.00
2621 GAT107 allosteric agonist and PAM of α7 nAChR €105.00
2109 PHA 543613 dihydrochloride nAChR agonist (α7 sub-unit selective) €85.00
1384 Varenicline dihydrochloride Nicotinic acetylcholine receptor agonist €95.00
2074 Varenicline tartrate Selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist €95.00

9 Item(s)

per page
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