K+ channels with two-pore domain (K2P) form a large family of hyperpolarizing channels. They produce background currents that oppose membrane depolarization and cell excitability. They are involved in cellular mechanisms of apoptosis, vasodilatation, anesthesia, pain, neuroprotection and depression. TREK-1 (K2P2.1), TREK-2 (K2P10.1), and TRAAK (TWIK Related Arachidonic acid Activated K+ channel) (K2P4.1), compose the TREK subfamily of K2P channels.[1]