P2X7

P2X receptors belong to a larger family of receptors known as the purinergic receptors[1]. Unlike the G-protein coupled P1 and P2Y receptors, the P2X receptors are ATP-gated cation channels with important roles in diverse pathophysiological processes (afferent signaling (including pain), regulation of renal blood flow, vascular endothelium, and inflammatory responses)[2].


[1] ATP-gated P2X cation-channels. M.F. Jarvisa, B.S. Khakh. Neuropharm. 2009, 56, 208–215.
[2] Signaling at Purinergic P2X Receptors. A. Surprenant, R.A. North. Ann. Rev. Physiol. 2009, 71, 333-359.

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Axon ID Name Description From price
2182 A 804598 Potent and selective P2X7 antagonist €125.00
1967 GW 791343 hydrochloride P2X7 receptor antagonist and allosteric modulator €90.00

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