P2X7
P2X receptors belong to a larger family of receptors known as the purinergic receptors[1]. Unlike the G-protein coupled P1 and P2Y receptors, the P2X receptors are ATP-gated cation channels with important roles in diverse pathophysiological processes (afferent signaling (including pain), regulation of renal blood flow, vascular endothelium, and inflammatory responses)[2].
[1] ATP-gated P2X cation-channels. M.F. Jarvisa, B.S. Khakh. Neuropharm. 2009, 56, 208–215.
[2] Signaling at Purinergic P2X Receptors. A. Surprenant, R.A. North. Ann. Rev. Physiol. 2009, 71, 333-359.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2182 | A 804598 | Potent and selective P2X7 antagonist | €125.00 | |
| 3835 | A-438079 hydrochloride | Competitive P2X7 antagonist | €110.00 | |
| 1967 | GW 791343 hydrochloride | P2X7 receptor antagonist and allosteric modulator | Inquire | |
| 3262 | HEI3090 | Positive modulator of the P2X7 receptor | €130.00 | |
| 2890 | JNJ 47965567 | Potent, brain-penetrant P2X7 antagonist | €130.00 | |