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JNJ 47965567
Axon 2890
CAS:
1428327-31-4
Purity:
99%
- Soluble in DMSO
- MF: C28H32N4O2S
- MW: 488.64
Description
Highly potent and brain penetrant P2X7 antagonist in human, rat, and mouse cell lines (pKi values of 7.9, 7.9 and 6.9 for human, rat, and human whole blood P2X7). Probe compound for the preclinical assessment of P2X7 blockade in animal models of neuro-inflammation. DMPK properties suitable for preclinical pharmacodynamics studies.
More Information
| Parent CAS No. | 1428327-31-4 |
|---|---|
| Chemical Name | N-((4-(4-Phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide |
| SMILES | C1C=C(C(NCC2(N3CCN(C4C=CC=CC=4)CC3)CCOCC2)=O)C(SC2C=CC=CC=2)=NC=1 |
| MFCD | MFCD28334214 |
| InChi | InChI=1S/C28H32N4O2S/c33-26(25-12-7-15-29-27(25)35-24-10-5-2-6-11-24)30-22-28(13-20-34-21-14-28)32-18-16-31(17-19-32)23-8-3-1-4-9-23/h1-12,15H,13-14,16-22H2,(H,30,33) |
| InChiKey | XREFXUCWSYMIOG-UHFFFAOYSA-N |
| CID | 66553218 |
| Short Description | P2X7 antagonist |
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