TRPM8

For all organisms, detection and adaptation to cold temperature is crucial to survival. Cold sensing in the innocuous range of cold (>10-15 °C) in the mammalian peripheral nervous system is thought to rely primarily on transient receptor potential (TRP) ion channels, most notably the menthol receptor, TRPM8. The TRP cation channel, subfamily C member 5 (TRPC5), is found to be highly sensitive to cold in the temperature range 37–25 °C, and is thus hypothesized to play a role in sensing cold[1]. Additionally, the channel may have an important role in the pathogenesis of hypertension[2].


[1] K. Zimmermann et al. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18114-9.
[2] K.T. Cheng et al. Contribution and regulation of TRPC channels in store-operated Ca2+ entry. Curr Top Membr. 2013;71:149-79.

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Axon ID Name Description From price
2423 M8-B hydrochloride Selective and potent antagonist of the TRPM8 channel €115.00
2483 PF 05105679 TRPM8 inhibitor with >100-fold selectivity and in vivo activity in humans €90.00
2498 RQ 00203078 Selective, potent, and orally active TRPM8 antagonist with in vivo activity €125.00

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