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L 838417
- Soluble in DMSO
- MF: C19H19F2N7O
- MW: 399.4
Description
L 838417 is a partial agonist at non-α1 GABAA receptors and an antagonist at α1-containing GABAA receptors. It is useful for dissecting GABAA receptor subtype contributions to inhibitory signaling.
Subtype-selective GABAA ligands help separate anxiolytic, anticonvulsant and sedative pharmacology. L 838417 is valuable for studies comparing α1 versus non-α1 GABAA receptor activity.
Key Features
- Partial agonist at non-α1 GABAA receptors
- Antagonist at α1-containing GABAA receptors
- Subtype-selective GABAA ligand
- Useful for differentiating sedative versus non-sedative receptor mechanisms
Applications
- GABAA receptor subtype pharmacology
- α1 versus non-α1 receptor comparison
- Anxiolytic and sedative mechanism studies
- Inhibitory neurotransmission research
More Information
| Parent CAS No. | 286456-42-6 |
|---|---|
| Chemical Name | 7-tert-Butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine |
| SMILES | C1(C(C)(C)C)=CC2=NN=C(C3C(F)=CC=C(F)C=3)N2N=C1OCC1N(C)N=CN=1 |
| MFCD | MFCD08690609 |
| InChi | InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3 |
| InChiKey | BQDUNOMMYOKHEP-UHFFFAOYSA-N |
| CID | 9908880 |
| Short Description | GABAA-α1 antagonist |
References
- J. Knabl et al. Reversal of pathological pain through specific spinal GABAAreceptor subtypes. Nature 2008, 451, 330-334.
- NR Mirza et al. Comparative cue generalisation profiles of L-838417, SL651498, zolpidem, CL218872, ocinaplon, bretazenil, zopiclone and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination. J. Ph. Exp. Ther. 2006, 316(3), 1291.
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